1,2-Aminosulfonylation of Alkenes via Photoexcited Cu(I)- Sub-strate Complex: A Three-Component Coupling Approach

We report a Cu(I)-photocatalyzed three-component coupling process to achieve the regioselective, vicinal 1,2-aminosulfonylations of alkenes. The critical aspect of this methodology is found in the utilization of in situ generated photoactive Cu(I)-amine substrate com-plexes, which facilitate the formal oxidation of Cu(I) to Cu(III) in a stepwise manner. In this way, the conceivable two-component chlorosulfonylation of alkenes is effectively suppressed, allowing the combination of styrenes, sulfonyl chlorides, and amines. Further-more, this protocol can be used to facilitate late-stage functionalization, thereby enabling the diversification of biomolecules