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Transition metal-free borylative functionalization of aryl fluoride with sodium dispersion in the presence of boron alkoxide

04 July 2025, Version 1
Working Paper
This content is an early or alternative research output and has not been peer-reviewed by Cambridge University Press at the time of posting.

Abstract

Borylative functionlization of aryl fluoride was perfomed by a transition metal-free process with sodium dispersion (SD). The reaction of 4-fluorobiphenyl with SD in the prsence of boron alkoxide (iPrOBpin) afforded the borylated product in up to 62% yield. The borylation reaction also proceeded with several aryl fluorides in good to excellent yields.

Keywords

sodium dispersion
aryl fluoride
borylation

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Version History

Jul 04, 2025 Version 1

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The content is available under CC BY NC ND 4.0 [opens in a new tab]

DOI

10.26434/chemrxiv-2025-mss6h
D O I: 10.26434/chemrxiv-2025-mss6h [opens in a new tab]

Author’s competing interest statement

The author(s) have declared they have no conflict of interest with regard to this content

Ethics

The author(s) have declared ethics committee/IRB approval is not relevant to this content

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