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A Chiroptical Switcher. Helical Inversion of Twisted Porphyrin Macrocycle Synergistically Controlled by Combined Stimuli of Solvent and Pressure

25 August 2025, Version 1
Working Paper
This content is an early or alternative research output and has not been peer-reviewed by Cambridge University Press at the time of posting.

Abstract

Herein, we report a chirally twisted porphyrin macrocycle, 1 is demonstrated to possess dynamically tunable chiroptical properties under hydrostatic pressure as an external stimulus. Upon hydrostatic pressurization, in halogenated solvents, the anisotropy (g) factor shifts from near zero to positive values, whereas in non-halogenated solvents, the g factor in-verts from negative to positive. These chiroptical switches are based on pressure-induced conformational change gov-erned by the interplay between macrocyclic flexibility and solvent polarity.

Keywords

Porphyrin
Hydrostatic pressure
Chiroptical switcher

Supplementary materials

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Title
A Chiroptical Switcher. Helical Inversion of Twisted Porphyrin Macrocycle Synergistically Controlled by Combined Stimuli of Solvent and Pressure
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Version History

Aug 25, 2025 Version 1

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License

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The content is available under CC BY 4.0 [opens in a new tab]

DOI

10.26434/chemrxiv-2025-v1nwk
D O I: 10.26434/chemrxiv-2025-v1nwk [opens in a new tab]

Funding

The Japan Society for the Promotion of Science
23H04873, 24K21795, 25H00897, 25K18021, 23H04020, 24K01536, 24K21791
Tokyo Ohka Foundation for The Promotion of Science and Technology

Author’s competing interest statement

The author(s) have declared they have no conflict of interest with regard to this content

Ethics

The author(s) have declared ethics committee/IRB approval is not relevant to this content

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