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Indanone Building Blocks from Lignin Related C-9 Plaform Molecules

07 October 2025, Version 3
Working Paper
This content is an early or alternative research output and has not been peer-reviewed by Cambridge University Press at the time of posting.

Abstract

Lignin-based aryl 3-hydroxypropanones were converted into indanones via domino dehydration/Nazarov cyclization in the presence of a superacid. The cyclization was studied in detail, and the resulting indanones were engaged in two postfunctionalizations: a reduction/elimination domino sequence and a ring expansion. Lastly, the method has been successfully applied to the synthesis of the anti-Alzheimer drug donepezil.

Keywords

Lignin valorization
Indanones
Domino reaction
Nazarov cyclization
Superacid

Supplementary materials

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Description
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Supporting Information v1
Description
Characterization data of all molecules reported in the manuscript.
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Version History

Oct 07, 2025 Version 3

Version Notes

typos have been corrected

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The content is available under CC BY NC 4.0 [opens in a new tab]

DOI

10.26434/chemrxiv-2025-w7877-v3
D O I: 10.26434/chemrxiv-2025-w7877-v3 [opens in a new tab]

Funding

Agence Nationale de la Recherche
ANR-22-CE92-0067-01
Deutsche Forschungsgemeinschaft
505782409

Author’s competing interest statement

The author(s) have declared they have no conflict of interest with regard to this content

Ethics

The author(s) have declared ethics committee/IRB approval is not relevant to this content

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