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A Snapshot Of Flavin-Conjugated Pt Anticancer Agents: Pt(IV)-To-Pt(II) Reduction Revealed By X-Ray Fluorescence Imaging And XANES

14 October 2025, Version 2
Working Paper
This content is an early or alternative research output and has not been peer-reviewed by Cambridge University Press at the time of posting.

Abstract

Synchrotron-based X-ray spectromicroscopy reveals enhanced cellular uptake and remarkably fast, efficient photoactivation of Pt(IV) prodrugs bearing flavin groups. These features correlate with superior anticancer activity compared to non-conjugated analogues, highlighting the potential of flavin-functionalised Pt(IV) complexes as candidates for photoactivated chemotherapy (PACT).

Keywords

Flavins
Platinum drugs
PACT
Intracellular activation
X-ray spectromicroscopy

Supplementary materials

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Title
A Snapshot Of Flavin-Conjugated Pt Anticancer Agents: Pt(IV)-To-Pt(II) Reduction Revealed By X-Ray Fluorescence Imaging And XANES
Description
Details on the Materials and Cell culture protocols and assays used. Details on the setups and methods for the acquisition of X-ray spectromicroscopy and its analysis. Further XFI images, XAS standards and analysis details.
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Supplementary weblinks

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Raw data for: "A Snapshot Of Flavin-Conjugated Pt Anticancer Agents: Pt(IV)-To-Pt(II) Reduction Revealed By X-Ray Fluorescence Imaging And XANES"
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Raw data for: "A Snapshot Of Flavin-Conjugated Pt Anticancer Agents: Pt(IV)-To-Pt(II) Reduction Revealed By X-Ray Fluorescence Imaging And XANES"
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Version History

Oct 14, 2025 Version 2

Version Notes

Small changes in text and Figure 4. Data availability statement added, and access to raw data provided

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The content is available under CC BY NC 4.0 [opens in a new tab]

DOI

10.26434/chemrxiv-2025-chsfq-v2
D O I: 10.26434/chemrxiv-2025-chsfq-v2 [opens in a new tab]

Funding

Spanish State Research Agency
PID2020-118176RJ-I100
Spanish State Research Agency
PID2022-139267OB-I00
Spanish State Research Agency
PRE2020-093560
Basque Government-Eusko Jaurlaritza
Elkartek KK-2023/00003
Basque Government-Eusko Jaurlaritza
IT1584-22
MICIU/AEI- “Severo Ochoa” Programme for Centres of Excellence in R&D
CEX2024-001494-S
Diamond Light Source
proposal MG33156

Author’s competing interest statement

The author(s) have declared they have no conflict of interest with regard to this content

Ethics

The author(s) have declared ethics committee/IRB approval is not relevant to this content

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