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Asymmetric Chemoenzymatic Synthesis of Podophyllotoxin and Related Aryltetralin Lignans

04 April 2019, Version 1
Working Paper
This content is an early or alternative research output and has not been peer-reviewed by Cambridge University Press at the time of posting.

Abstract

We report a concise chemoenzymatic synthesis of podophyllotoxin. Highlights of the synthesis include the use of enzymatic oxidative coupling to generate the tetracyclic core of the natural product, and late stage chemical oxidation to install the requisite secondary alcohol.

Keywords

Podophyllotoxin
Total synthesis
Biocatalysis

Supplementary materials

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ODD SI 040319 FINAL
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Now Published

Asymmetric Chemoenzymatic Synthesis of (−)‐Podophyllotoxin and Related Aryltetralin Lignans [opens in a new tab]
Jian Li, Xiao Zhang, Hans Renata journal article
Angewandte Chemie International Edition , Volume 58, Issue 34
Online publication date: Jul 17, 2019

Version History

Apr 04, 2019 Version 1

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The content is available under CC BY NC ND 4.0 [opens in a new tab]

DOI

10.26434/chemrxiv.7946729.v1
D O I: 10.26434/chemrxiv.7946729.v1 [opens in a new tab]

Funding

GM128895

Author’s competing interest statement

No conflict of interest

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