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Construction of a Reduction-responsive DNA Microsphere using a Reduction-cleavable Spacer based on a Nitrobenzene Scaffold

14 February 2022, Version 1
Working Paper
This content is an early or alternative research output and has not been peer-reviewed by Cambridge University Press at the time of posting.

Abstract

We describe that the reduction-cleavable spacer (RCS) containing a nitrobenzene scaffold can be incorporated into a single-stranded DNA sequence to enable the construction of a reduction-responsive DNA architecture with spherical morphology at micrometer scale. The RCS could allow for the introduction of the reduction-responsiveness into various functional oligonucleotides as well as nucleic acid-based architectures.

Keywords

Self-assembly
DNA structures
Cleavage reaction
Reduction

Supplementary materials

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The supporting information contains a detailed description of the experiments and additional data (Fig. S1-S6).
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Now Published

Construction of a Reduction‐responsive DNA Microsphere using a Reduction‐cleavable Spacer based on a Nitrobenzene Scaffold [opens in a new tab]
Sayuri L. Higashi, Ayaka Isogami, Junko Takahashi, Aya Shibata, Koichiro M. Hirosawa, Kenichi G.N. Suzuki, Shunsuke Sawada, Shinya Tsukiji, Kazunori Matsuura, Masato Ikeda journal article
Chemistry – An Asian Journal
Online publication date: Mar 25, 2022

Version History

Feb 14, 2022 Version 1

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The content is available under CC BY NC ND 4.0 [opens in a new tab]

DOI

10.26434/chemrxiv-2022-j4gx5
D O I: 10.26434/chemrxiv-2022-j4gx5 [opens in a new tab]

Funding

Uehara Memorial Foundation
JSPS Core-to-Core Program
iGCORE collaboration grant
Grant-in-Aid for Scientific Research (C) of the Japan Society for the Promotion of Science
20K05563
JSPS Research Fellowship for Young Scientists

Author’s competing interest statement

The author(s) have declared they have no conflict of interest with regard to this content

Ethics

The author(s) have declared ethics committee/IRB approval is not relevant to this content

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