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Abstract
Backgrounds
Delirium is a common event among Covid-19 hospitalized patients. In this work, we aim at evaluate the predictors of delirium and its impact on mortality and disability in Covid-19 patients.
Methods
Two thousand two hundred eighty-eight Covid-19 patients were admitted to Brescia hospital from 2020 to 2022. Clinical and laboratory features were extracted from digital medical records. Statistical analysis was implemented to evaluate predictive factors of delirium, mortality and disability at discharge.
Results
Out of 2288 patients, 223 (9.7%) experienced delirium (Del+). Compared to patients without delirium (Del-), Del+ subjects were older, exhibited worse premorbid conditions and disease severity, higher mortality rates and discharge outcomes. Age, premorbid disability and Covid-19 severity were the strongest predictors of both delirium and poor outcomes.
Conclusion
Older and frail Covid-19 patients are at higher risk of delirium, which is an important predictor of in hospital mortality and poor outcomes, independently from disease severity.
Supplementary materials
Title
Figure 1
Description
Predictors of mortality in Cox regression analysis between Covid-19 patients with and without delirium.
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Title
Supplementary Tables
Description
Supplementary Table S1.: Cox regression analysis between Covid-19 patients with delirium.
Supplementary Table S2.: Cox regression analysis between Covid-19 patients without delirium.
Supplementary Table S3.: Logistic regression evaluating predictors of poor outcomes, expressed by ∆mRS>1 in Covid-19 patients with delirium.
Supplementary Table S4.: Logistic regression evaluating predictors of ∆mRS>1 in Covid-19 patients without delirium.
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