Long-term persistence of markers of autoimmune β-cell destruction and residual C-peptide secretion in patients from a South American cohort with type 1 diabetes mellitus

22 October 2023, Version 1
This content is an early or alternative research output and has not been peer-reviewed by Cambridge University Press at the time of posting.

Abstract

Introduction . It was previously believed that markers of the autoimmune process, specifically autoantibodies ( Abs ) against β cells in patients with type 1 diabetes mellitus (DM1), persist only during the first 5 years of the disease. Contrary to established opinion, some patients with long- term T1D showed elevated levels of markers of autoimmune β-cell destruction as well as residual insulin secretory function, determined by fasting C-peptide level. According to various sources, the prevalence of this type of observations ranges between 12 and 48%.

Keywords

type 1 diabetes mellitus
autoantibodies
long-term autoimmunity
residual insulin secretion.

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