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Nanoscale morphometric visualization of the endoplasmic reticulum under stress using a bright zinc complex

08 January 2026, Version 1
Working Paper
This content is an early or alternative research output and has not been peer-reviewed by Cambridge University Press at the time of posting.

Abstract

The endoplasmic reticulum (ER) undergoes dynamic morphological changes during cellular stress and disease, yet specific staining and nanoscale observation remain challenging. We report a highly bright, biocompatible, and nontoxic fluorescent Zn-complex for super-resolution imaging of the ER. Super-resolution radial fluctuation microscopy (SRRF) resolves the smallest tubular diameter of ER, 110 nm, and quantifies stress-induced morphological remodeling.

Keywords

Endoplasmic reticulum
Single-molecule fluorescence microscopy
Morphological stress
Super-resolution imaging

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Version History

Jan 08, 2026 Version 1

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The content is available under CC BY NC ND 4.0 [opens in a new tab]

DOI

10.26434/chemrxiv-2026-xz82l
D O I: 10.26434/chemrxiv-2026-xz82l [opens in a new tab]

Author’s competing interest statement

The author(s) have declared they have no conflict of interest with regard to this content

Ethics

The author(s) have declared ethics committee/IRB approval is not relevant to this content

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