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Chapter 27 - Clinical Peripheral Nerve Injury Models

from Section 2 - Clinical Neurosurgical Diseases

Published online by Cambridge University Press:  04 January 2024

By
Andrew S. Jack ,
Charlotte J. Huie  and
Line Jacques
Edited by
Farhana Akter ,
Nigel Emptage ,
Florian Engert  and
Mitchel S. Berger
Farhana Akter
Affiliation:
Harvard University, Massachusetts
Nigel Emptage
Affiliation:
University of Oxford
Florian Engert
Affiliation:
Harvard University, Massachusetts
Mitchel S. Berger
Affiliation:
University of California, San Francisco
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Summary

Peripheral nerve injuries(PNIs) come in many varieties and their mechanism of injury can have a tremendous impact on a patient’s expected outcome. As discussed in Chapter 26, depending on the mechanism, PNIs have a relatively well-choreographed response to injury. However, much of this sequence will be influenced by both modifiable and non-modifiable prognostic factors. Furthermore, this mechanism of injury and its severity will also help dictate the appropriate treatment of the injury. In this chapter, basic science principles and models addressing PNIs are more specifically examined as they occur in the context of trauma, entrapment, tumors, and the changes occurring in acute and chronic pain states. Clinical case examples of such injuries will be discussed to conclude each section, including their respective management.

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Neuroscience for Neurosurgeons , pp. 355 - 368
Publisher: Cambridge University Press
Print publication year: 2024

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