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The cluster of differentiation 36 (CD36) rs1761667 polymorphism interacts with dietary patterns to affect cardiometabolic risk factors and metabolic syndrome risk in apparently healthy individuals

Published online by Cambridge University Press:  16 March 2023

Zeinab Yazdanpanah Open the ORCID record for Zeinab Yazdanpanah [Opens in a new window] ,
Amin Salehi-Abargouei ,
Mehdi Mollahosseini ,
Mohammad Hasan Sheikhha ,
Masoud Mirzaei Open the ORCID record for Masoud Mirzaei [Opens in a new window]  and
Hassan Mozaffari-Khosravi
Zeinab Yazdanpanah
Affiliation:
Department of Nutrition, School of Public Health, Shahid Sadoughi University of Medical Sciences, Yazd, Iran Nutrition and Food Security Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
Amin Salehi-Abargouei
Affiliation:
Department of Nutrition, School of Public Health, Shahid Sadoughi University of Medical Sciences, Yazd, Iran Nutrition and Food Security Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran Yazd Cardiovascular Research Centre, Non-communicable Research Institute, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
Mehdi Mollahosseini
Affiliation:
Department of Nutrition, School of Public Health, Shahid Sadoughi University of Medical Sciences, Yazd, Iran Nutrition and Food Security Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
Mohammad Hasan Sheikhha
Affiliation:
Department of Medical Genetics, Shahid Sadoughi University of Medical Sciences, Yazd, Iran Abortion Research Center, Yazd Reproductive Sciences Institute, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
Masoud Mirzaei
Affiliation:
Yazd Cardiovascular Research Centre, Non-communicable Research Institute, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
Hassan Mozaffari-Khosravi*
Affiliation:
Department of Nutrition, School of Public Health, Shahid Sadoughi University of Medical Sciences, Yazd, Iran Nutrition and Food Security Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
*
*Corresponding author: Hassan Mozaffari-Khosravi, email mozaffari.kh@gmail.com
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Abstract

Several studies have examined the association between CD36 rs1761667 polymorphism with cardiometabolic risk factors and metabolic syndrome (MetS). This study aimed to investigate the interactions between rs1761667 polymorphism and dietary patterns on the cardiometabolic risk factors and the risk of MetS in apparently healthy individuals aged 20–70 years. Food consumption data were acquired using a validated semi-quantitative FFQ. Dietary patterns were identified by factor analysis. CD36 rs1761667 was genotyped by PCR-restriction fragment length polymorphism. The gene–diet interaction was detected by the general linear model or logistic regression. Significant or marginally significant interactions were observed between healthy dietary pattern (HDP) and CD36 rs1761667 on weight (P = 0·006), BMI (P = 0·009), waist circumference (P = 0·005), hip circumference (P = 0·06), body muscle percentage (P = 0·02), body fat percentage (P = 0·09), TAG-glucose index (P = 0·057), atherogenic index of plasma (P = 0·07), the risk of MetS (P = 0·02), risk of abdominal obesity (P = 0·02) and elevated blood pressure (P = 0·07). Besides, a gene–diet interaction was detected between the traditional dietary pattern and rs1761667 variants on odds of hypertriglyceridaemia (P = 0·02). The adherence to HDP was associated with a lower weight, BMI and higher odds of HDL-cholesterol only in A-allele carriers. In conclusion, adherence to HDP (a diet with high fibre, fish and dairy products) can be more effective on some cardiometabolic risk factors and risk of MetS components in the A-allele carrier than the GG genotype of rs1761667 polymorphism. However, future studies are required to shed light on this issue.

Keywords

CD36 proteinSNPrs1761667Cardiometabolic risk factorsMetabolic syndrome risk
Type
Research Article
Information
British Journal of Nutrition , Volume 130 , Issue 9 , 14 November 2023 , pp. 1510 - 1520
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Copyright
© The Author(s), 2023. Published by Cambridge University Press on behalf of The Nutrition Society

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