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Factors involved in the level of functioning of patients with schizophrenia according to latent variable modeling

Published online by Cambridge University Press:  15 April 2020

P.-M. Llorca ,
O. Blanc ,
L. Samalin ,
M. Bosia ,
R. Cavallaro  and
on behalf of the EGOFORS initiative
P.-M. Llorca*
Affiliation:
Service de psychiatrie B, CHU de Clermont-Ferrand, 58, rue Montalembert, 63000Clermont-Ferrand, France
O. Blanc
Affiliation:
Service de psychiatrie B, CHU de Clermont-Ferrand, 58, rue Montalembert, 63000Clermont-Ferrand, France
L. Samalin
Affiliation:
Service de psychiatrie B, CHU de Clermont-Ferrand, 58, rue Montalembert, 63000Clermont-Ferrand, France
M. Bosia
Affiliation:
Department of clinical neurosciences, San Raffaele universitary, scientific institute hospital, Via Stamira d’Ancona 20, 20127Milano, Italy
R. Cavallaro
Affiliation:
Department of clinical neurosciences, San Raffaele universitary, scientific institute hospital, Via Stamira d’Ancona 20, 20127Milano, Italy
*
*Corresponding author. Tel.:+33 4 73 75 21 24; fax: +33 4 73 75 21 29. E-mail address:pmllorca@chu-clermont-ferrand.fr (P.-M. Llorca), oblanc@chu-clermont-ferrand.fr (O. Blanc), lsamalin@chu-clermontferrand.fr (L. Samalin).
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Abstract

Purpose

This study aimed at using latent variable modelling to explore the significantly contributing variables to functioning in schizophrenia patients.

Methods

The study cohort comprised 296 schizophrenia patients evaluated once for demographic characteristics, functioning (FROGS, SWN-K, QLS) and symptomatology (Positive and Negative Syndrome Scale [PANSS]). First exploratory multivariate analyses were conducted and then a model with functioning as a latent variable was proposed and tested with the data.

Results

Symptomatology as negative, cognitive and excitation factor are significant predictors of functioning assessed through FROGS (P<0.0001), SWN-K and QLS (P<0.001). The model was constructed with functioning defined as a latent variable, indicators are subscores on FROGS, SWN-K, QLS and exogenous variable included symptomatology, Duration of Untreated Psychosis (DUP) and educational level.

Conclusion

Using the five clinical dimensions of the PANSS, (Positive, Negative, Cognitive, Anxiety/Depression and Excitation) the negative and cognitive dimensions are highly correlated via the latent variable to the three dimensions of functioning evaluated by the FROGS: “daily life”, “social functioning” and “treatment” and the QLS subscores (interpersonnal, common object, instrumental role). Educationnal level is positively linked to functioning but not DUP. The model emphasizes the need for treatment strategies that have an effect on cognitive-factors, to improve functioning in schizophrenia.

Keywords

FunctioningCognitive and negative symptomsModelingSchizophrenia

Information

Type
Original articles
Information
European Psychiatry , Volume 27 , Issue 6 , August 2012 , pp. 396 - 400
Copyright
Copyright © Elsevier Masson SAS 2012

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References

Aki, H., Tomotake, M., Kaneda, Y., Iga, J., Kinouchi, S., Shibuya-Tayoshi, S.et al.Subjective and objective quality of life, levels of life skills, and their clinical determinants in outpatients with schizophrenia. Psychiatry Res. 158 1: 2008 19–25.CrossRefGoogle ScholarPubMed
Buchanan, R.W.Persistent negative symptoms in schizophrenia: an overview. Schizophr Bull. 33 4: 2007 1013–1022.CrossRefGoogle ScholarPubMed
Burns, T.Evolution of outcome measures in schizophrenia. Br J Psychiatry Suppl. 2007; 50: s1–s6.CrossRefGoogle Scholar
Green, M.F.What are the functional consequences of neurocognitive deficits in schizophrenia? Am J Psychiatry. 153 3: 1996 321–330.Google Scholar
Green, M.F., Kern, R.S., Braff, D.L., Mintz, J.Neurocognitive deficits and functional outcome in schizophrenia: are we measuring the “right stuff”’? Schizophr Bull. 26 1: 2000 119–136.CrossRefGoogle Scholar
Greenwood, K.E., Landau, S., Wykes, T.Negative symptoms and specific cognitive impairments as combined targets for improved functional outcome within cognitive remediation therapy. Schizophr Bull. 31 4: 2005 910–921.CrossRefGoogle ScholarPubMed
Haim, R., Rabinowitz, J., Bromet, E.The relationship of premorbid functioning to illness course in schizophrenia and psychotic mood disorders during two years following first hospitalization. J Nerv Ment Dis. 194 10: 2006 791–795.CrossRefGoogle ScholarPubMed
Harvey, P.D., Koren, D., Reichenberg, A., Bowie, C.R.Negative symptoms and cognitive deficits: what is the nature of their relationship? Schizophr Bull. 32 2: 2006 250–258.CrossRefGoogle ScholarPubMed
Hatcher, L. A step by step approach to using SAS factor analysis and structural modeling factor. 1994.Google Scholar
Heinrichs, D.W., Hanlon, T.E., Carpenter, W.T. Jr.The Quality of Life Scale: an instrument for rating the schizophrenic deficit syndrome. Schizophr Bull. 10 3: 1984 388–398.CrossRefGoogle ScholarPubMed
Hofer, A., Rettenbacher, M.A., Widschwendter, C.G., Kemmler, G., Hummer, M., Fleischhacker, W.W.Correlates of subjective and functional outcomes in outpatient clinic attendees with schizophrenia and schizoaffective disorder. Eur Arch Psychiatry Clin Neurosci. 256 4: 2006 246–255.CrossRefGoogle ScholarPubMed
Hu, L., Bentler, P.Cutoff criteria for fit indexes in covariance structure analysis: coventional criteria versus new alternative. SEM. 6 1: 1999 1–55.Google Scholar
Keshavan, M.S., Amirsadri, A.Early intervention in schizophrenia: current and future perspectives. Curr Psychiatry Rep. 9 4: 2007 325–328.CrossRefGoogle ScholarPubMed
Kurtz, M.M., Moberg, P.J., Ragland, J.D., Gur, R.C., Gur, R.E.Symptoms versus neurocognitive test performance as predictors of psychosocial status in schizophrenia: a 1- and 4-year prospective study. Schizophr Bull. 31 1: 2005 167–174.CrossRefGoogle ScholarPubMed
Lancon, C., Aghababian, V., Llorca, P.M., Bernard, D., Auquier, P.An exploration of the psychometric properties of the French version of the Positive and Negative Syndrome Scale. Can J Psychiatry. 44 9: 1999 893–900.CrossRefGoogle ScholarPubMed
Llorca, P.M., Lancon, C., Lancrenon, S., Bayle, F.J., Caci, H., Rouillon, F.et al.The “Functional Remission of General Schizophrenia” (FROGS) scale: development and validation of a new questionnaire. Schizophr Res. 113 2–3: 2009 218–225.CrossRefGoogle ScholarPubMed
MacBeth, A., Gumley, A.Premorbid adjustment, symptom development and quality of life in first episode psychosis: a systematic review and critical reappraisal. Acta Psychiatr Scand. 117 2: 2008 85–99.CrossRefGoogle ScholarPubMed
Maccabe, J.H.Population-based cohort studies on premorbid cognitive function in schizophrenia. Epidemiol Rev. 2008; 30: 77–83.CrossRefGoogle Scholar
Naber, D.A self-rating to measure subjective effects of neuroleptic drugs, relationships to objective psychopathology, quality of life, compliance and other clinical variables. Int Clin Psychopharmacol. 10 Suppl3 1995 133–138.Google ScholarPubMed
Naber, D., Moritz, S., Lambert, M., Pajonk, F.G., Holzbach, R., Mass, R.et al.Improvement of schizophrenic patients’ subjective well-being under atypical antipsychotic drugs. Schizophr Res. 50 1–2: 2001 79–88.CrossRefGoogle ScholarPubMed
Rabinowitz, J., Harvey, P.D., Eerdekens, M., Davidson, M.Premorbid functioning and treatment response in recent-onset schizophrenia. Br J Psychiatry. 2006; 189: 31–35.CrossRefGoogle ScholarPubMed
Tomotake, M., Kaneda, Y., Iga, J., Kinouchi, S., Tayoshi, S., Motoki, I.et al.Subjective and objective measures of quality of life have different predictors for people with schizophrenia. Psychol Rep. 99 2: 2006 477–487.CrossRefGoogle ScholarPubMed
Velligan, D.I., Mahurin, R.K., Diamond, P.L., Hazleton, B.C., Eckert, S.L., Miller, A.L.The functional significance of symptomatology and cognitive function in schizophrenia. Schizophr Res. 25 1: 1997 21–31.CrossRefGoogle Scholar
Yamauchi, K., Aki, H., Tomotake, M., Iga, J., Numata, S., Motoki, I.et al.Predictors of subjective and objective quality of life in outpatients with schizophrenia. Psychiatry Clin Neurosci. 62 4: 2008 404–411.CrossRefGoogle ScholarPubMed
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