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Corticostriatal functional connectivity in non-medicated patients with obsessive-compulsive disorder

Published online by Cambridge University Press:  16 April 2020

Y. Sakai ,
J. Narumoto ,
S. Nishida ,
T. Nakamae ,
K. Yamada ,
T. Nishimura  and
K. Fukui
Y. Sakai*
Affiliation:
Department of Psychiatry, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 465 Kajii-cho, Kawaramachi-Hirokoji, Kamigyo-ku, Kyoto 602-8566, Japan
J. Narumoto
Affiliation:
Department of Psychiatry, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 465 Kajii-cho, Kawaramachi-Hirokoji, Kamigyo-ku, Kyoto 602-8566, Japan
S. Nishida
Affiliation:
Department of Psychiatry, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 465 Kajii-cho, Kawaramachi-Hirokoji, Kamigyo-ku, Kyoto 602-8566, Japan
T. Nakamae
Affiliation:
Department of Psychiatry, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 465 Kajii-cho, Kawaramachi-Hirokoji, Kamigyo-ku, Kyoto 602-8566, Japan
K. Yamada
Affiliation:
Department of Radiology, Graduate School of Medical Science Kyoto Prefectural University of Medicine, 465 Kajii-cho, Kawaramachi-Hirokoji, Kamigyo-ku, Kyoto 602-8566, Japan
T. Nishimura
Affiliation:
Department of Radiology, Graduate School of Medical Science Kyoto Prefectural University of Medicine, 465 Kajii-cho, Kawaramachi-Hirokoji, Kamigyo-ku, Kyoto 602-8566, Japan
K. Fukui
Affiliation:
Department of Psychiatry, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 465 Kajii-cho, Kawaramachi-Hirokoji, Kamigyo-ku, Kyoto 602-8566, Japan
*
*Corresponding author. Tel.: +81 75 251 5612, fax: +81 75 251 5839. E-mail address: yuki1209@koto.kpu-m.ac.jp (Y. Sakai).
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Abstract

The basal ganglia represents a key component of the pathophysiological model for obsessive-compulsive disorder (OCD). This brain region is part of several neural circuits, including the orbitofronto-striatal circuit and dorsolateral prefronto-striatal circuit. There are, however, no published studies investigating those circuits at a network level in non-medicated patients with OCD. Resting state functional magnetic resonance imaging scans were obtained from 20 non-medicated patients with OCD and 23 matched healthy volunteers. Voxelwise statistical parametric maps testing strength of functional connectivity of three striatal seed regions of interest (ROIs) with remaining brain regions were calculated and compared between groups. We performed additional correlation analyses between strength of connectivity and the severity scores for obsessive-compulsive symptoms, depression, and anxiety in the OCD group. Positive functional connectivity with the ventral striatum was significantly increased (Pcorrected <.05) in the orbitofrontal cortex, ventral medial prefrontal cortex and dorsal lateral prefrontal cortex of subjects with OCD. There was no significant correlation between measures of symptom severity and the strength of connectivity (Puncorrected <.001). This is the first study to investigate the corticostriatal connectivity in non-medicated patients with OCD. These findings provide the first direct evidence supporting a pathophysiological model involving basal ganglia circuitry in OCD.

Keywords

Obsessive-compulsive disorderFunctional magnetic resonance imagingResting stateFunctional connectivityBasal gangliaOrbitofrontal cortex
Type
Original article
Information
European Psychiatry , Volume 26 , Issue 7 , October 2011 , pp. 463 - 469
Copyright
Copyright © European Psychiatric Association 2010

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Footnotes

☆

This research received no specific grant from any funding agency in the public, commercial, or not-for-profit sectors. All authors had full access to the data used in this study and corresponding author Yuki Sakai takes responsibility for the integrity of the data and the accuracy of the data analysis.

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