Hostname: page-component-78c5997874-94fs2 Total loading time: 0 Render date: 2024-10-31T19:48:56.778Z Has data issue: false hasContentIssue false

Meningocele and ankyloblepharon following in utero exposure to olanzapine

Published online by Cambridge University Press:  16 April 2020

M. Arora*
Affiliation:
Central Institute of Psychiatry, Kanke, Ranchi 834006, Jharkhand, India
S.K. Praharaj
Affiliation:
Central Institute of Psychiatry, Kanke, Ranchi 834006, Jharkhand, India
*
*Corresponding author. Tel.: +91 651 223 2462. E-mail address: drmanu2004@rediffmail.com (M. Arora), samirpsyche@yahoo.co.in (S.K. Praharaj).
Get access

Abstract

Although atypical antipsychotics are widely used during pregnancy, their safety is not well established. This case highlights the possible teratogenic effect of olanzapine, in which the baby was born with meningocele and ankyloblepharon. It is suggested that olanzapine may interfere with embryonic development at different stages of pregnancy.

Type
Short communication
Copyright
Copyright © Elsevier SAS 2006

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Bennedsen, B.E.Adverse pregnancy outcome in schizophrenic women: occurrence and risk factors. Schizophr. Res 1998;33:126.CrossRefGoogle ScholarPubMed
Casiano, M.E., Hawkins, D.R.Major mental illness and child bearing. A role for the consultation–liaison psychiatrist in obstetrics. Psychiatr. Clin. North Am 1987;10:3551.CrossRefGoogle Scholar
Dickson, R.A., Dawson, D.T.Olanzapine and pregnancy. Can. J. Psychiatry 1998;43:196197.Google Scholar
Goldstein, D.J., Corbin, L.A., Fung, M.C.Olanzapine-exposed pregnancies and lactation: early experience. J. Clin. Psychopharmacol 2000;20:399403.CrossRefGoogle ScholarPubMed
Hay, R.J., Wells, R.S.The syndrome of ankyloblepharon, ectodermal defects and cleft lip and palate: an autosomal condition. Br. J. Dermatol 1976;94:277289.CrossRefGoogle ScholarPubMed
Kirchheiner, J., Berghofer, A., Bolk-Weischedel, D.Healthy outcome under olanzapine treatment in a pregnant woman. Pharmacopsychiatry 2000;33:7880.Google Scholar
Lim, L.Olanzapine and pregnancy. Aust. N. Z. J. Psychiatry 2001;35:856857.CrossRefGoogle Scholar
Littrell, K.H., Johnson, C.G., Peabody, C.D., Hilligoss, N.Antipsychotics during pregnancy. Am. J. Psychiatry 2000;157:1342.CrossRefGoogle ScholarPubMed
McKenna, K., Koron, G., Tetelbaum, M., Wilton, L., Shaki, S.Pregnancy outcome of women using atypical antipsychotic drugs: a prospective comparative study. J. Clin. Psychiatry 2005;66:444449.CrossRefGoogle ScholarPubMed
Mendhekar, D.N., War, L., Sharma, J.B., Jiloha, R.C.Olanzapine and pregnancy. Pharmacopsychiatry 2002;35:122123.CrossRefGoogle Scholar
Mitchell, L.E., Adzick, N.S., Melchionne, J., Pascuariello, P.S., Sutton, L.N., Whitehead, A.S.Spina bifida. Lancet 2004;364:18851895.CrossRefGoogle ScholarPubMed
Nurnberg, H.G.An overview of somatic treatment of psychosis during pregnancy and postpartum. Gen. Hosp. Psychiatry 1989;11:328338.CrossRefGoogle ScholarPubMed
Submit a response

Comments

No Comments have been published for this article.