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Randomised clinical trial comparing oral versus depot formulations of zuclopenthixol in patients with schizophrenia and previous violence

Published online by Cambridge University Press:  16 April 2020

C. Arango ,
I. Bombín ,
T. González-Salvador ,
I. García-Cabeza  and
J. Bobes
C. Arango*
Affiliation:
Hospital General Universitario Gregorio Marañón, Department of Psychiatry, C/Ibiza, 43, 28009Madrid, Spain
I. Bombín
Affiliation:
Hospital General Universitario Gregorio Marañón, Department of Psychiatry, C/Ibiza, 43, 28009Madrid, Spain
T. González-Salvador
Affiliation:
Centro de Salud Mental de Colmenar Viejo, Madrid, Spain
I. García-Cabeza
Affiliation:
Hospital General Universitario Gregorio Marañón, Department of Psychiatry, C/Ibiza, 43, 28009Madrid, Spain
J. Bobes
Affiliation:
Department of Medicine-Psychiatry, Universidad de Oviedo, C/Julián Clavería 6, 33006Oviedo, Spain
*
*Corresponding author. Tel.: +34 91 667 776419; fax: +34 91 426 5005. E-mail address:carango@mce.hggm.es (C. Arango).
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Abstract

Objective

The aim of this longitudinal study was to determine whether the depot formulation of an antipsychotic reduces violence in outpatients with schizophrenia as compared to oral administration of the same antipsychotic.

Methods

Forty-six previously violent patients with schizophrenia were randomised to receive treatment with oral or depot zuclopenthixol for 1 year. Clinicians interviewed patients at baseline and every month thereafter to assess treatment adherence. An interviewer blinded to treatment assignments interviewed an informant about any violent behaviour during the previous month.

Results

Violence during the follow-up year was inversely proportional to treatment adherence, better compliance, and greater reduction of positive symptoms. Lower frequency of violent acts was observed in the depot group. The level of insight at baseline was not significantly associated with violence recidivism. Regardless of route of administration, treatment non-adherence was the best predictor of violence.

Conclusions

Some patients with schizophrenia and prior violent behaviour may benefit from the depot formulation of antipsychotic medication.

Keywords

SchizophreniaViolenceTreatment adherenceDepot medication
Type
Original article
Information
European Psychiatry , Volume 21 , Issue 1 , January 2006 , pp. 34 - 40
Copyright
Copyright © Elsevier SAS 2006

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