Article contents
Adulthood asthma as a consequence of childhood adversity: a systematic review of epigenetically affected genes
Published online by Cambridge University Press: 08 March 2022
Abstract
There is an accumulating data that shows relation between childhood adversity and vulnerability to chronic diseases as well as epigenetic influences that in turn give rise to these diseases. Asthma is one of the chronic diseases that is influenced from genetic regulation of the inflammatory biomolecules and therefore the hypothesis in this research was childhood adversity might have caused epigenetic differentiation in the asthma-related genes in the population who had childhood trauma. To test this hypothesis, the literature was systematically reviewed to extract epigenetically modified gene data of the adults who had childhood adversity, and affected genes were further evaluated for their association with asthma. PRISMA guidelines were adopted and PubMed and Google Scholar were included in the searched databases, to evaluate epigenetic modifications in asthma-related genes of physically, emotionally or sexually abused children. After retrieving a total of 5245 articles, 36 of them were included in the study. Several genes and pathways that may contribute to pathogenesis of asthma development, increased inflammation, or response to asthma treatment were found epigenetically affected by childhood traumas. Childhood adversity, causing epigenetic changes in DNA, may lead to asthma development or influence the course of the disease and therefore should be taken into account for the prolonged health consequences.
- Type
- Original Article
- Information
- Journal of Developmental Origins of Health and Disease , Volume 13 , Issue 6 , December 2022 , pp. 674 - 682
- Copyright
- © The Author(s), 2022. Published by Cambridge University Press in association with International Society for Developmental Origins of Health and Disease
Footnotes
Part of this work has been presented at Turkish Thoracic Society’s 22nd Annual Congress in April 2019.
References
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