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The Protective effect of irradiated metacercariae of Fasciola gigantica against homologous challenge in sheep

Published online by Cambridge University Press:  05 June 2009

Haga A/gadir ,
E. M. Haroun  and
A. A. Gameel
Haga A/gadir
Affiliation:
Faculty of Veterinary Science, University of Khartoum, Khartoum North, P.O. Box 32, Sudan.
E. M. Haroun*
Affiliation:
Faculty of Veterinary Science, University of Khartoum, Khartoum North, P.O. Box 32, Sudan.
A. A. Gameel
Affiliation:
Faculty of Veterinary Science, University of Khartoum, Khartoum North, P.O. Box 32, Sudan.
*
*College of Agriculture and Veterinary Medicine, Gasseem, Buraydah, P.O. Box 1482, Saudi Arabia
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Abstract

Five lambs were each sensitized with 400 metacercariae of Fasciola gigantica irradiated at 3 kr gammarays. Eight weeks later, they were each challenged together with 5 controls with 500 non-irradiated metacercariae. Eight weeks later, all of the animals were necropsied and the worm burdens determined. The lambs which received the sensitizing infections had 80% less worms than the controls. The sensitized lambs also showed less hepatic damage compared with the controls as indicated by lower levels of the serum enzyme glutamate dehydrogenase. The blood indices showed insigicant reductions in the sensitized lambs whereas marked reductions were found in the erythrocytes, packed cell volume and haemoglobin values of the challenge controls. Bilirubinaemia was also evident in this latter group.

Information

Type
Research Papers
Information
Journal of Helminthology , Volume 61 , Issue 2 , June 1987 , pp. 137 - 142
Copyright
Copyright © Cambridge University Press 1987

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References

REFERENCES

A/gadir, Haga (1983) Studies on naturally-occurring and exprimental ovine fascioliasis in the Sudan. M.V.Sc. Thesis, University of Khartoum.Google Scholar
Armour, J., Dargie, J. D., Doyle, J. J., Murray, M., Robinson, P.. & Rushton, B. (1974).Immunization against fascioliasis. Proceedings of the Third International Congress of Parasitology, Munich, 494.Google Scholar
Bitakaramire, P. (1973) Preliminary studies on the immunization of cattle against fascioliasis using gamma irradiated metacercariae of Fasciola gigantica. In: Isotopes and Radiation in Parasitology 3. International Atomic Energy Agency, Vienna, 23–32.Google Scholar
Boray, J. C. (1967) The effect of host reaction to exprimental fasciola hepatica infection in sheep and cattle. Proceedings of the Third International Conference of the World Association for the Advancement of Veterinary Parasitology. Lyons, 84–96.Google Scholar
Bushara, H. O., Hussein, M. F., Taylor, M. G., Dargie, J. D., Marshall, T.F.. & Nelson, G. S. (1978).Immunization of calves against Schistosoma bovis using irradiated cercariae or schistosomula of S. bovis. Parasitology, 77, 303–311.CrossRefGoogle ScholarPubMed
Campell, N. J., Gregg, P., Kelly, J.D.. & Dineen, J. K. (1978) Failure to induce homologous immunity to fasciola hepatica in sheep vaccinated with irradiated metacercarie. Vaterinary Parasitology, 4, 143–152.CrossRefGoogle Scholar
Dangerfield, W. G. & Finlayson, R. (1953) Estimation of bilirubin in serum. Journal of Clinical Pathology, 6, 173–177.CrossRefGoogle ScholarPubMed
Dargie, J. D., Armour, J., Rushton, B.. & Murray, M. (1974) Immune mechanisms and hepatic fibrosis in fascioliasis. In: Proceedings of the Sixth International Conference of the World Association for the Advancement of Veterinary Parasitology, (editor E.J.L., Soulsby), pp. 249–271. Academic Press: New York.Google Scholar
Dean, D. A. (1983) Schistosoma and related genera: Acquired resistance in mice. Experimental Parasitology, 55, 1–104.CrossRefGoogle ScholarPubMed
Ford, E. J. H. & Boyd, J. W. (1962) Cellular damage and changes in biliary excreation in liver lesions of cattle. Journal of pathology and Bacteriology, 83, 39–48.CrossRefGoogle Scholar
Jarret, E. J. H., Jennings, F. W., Martin, B., Macintyre, W. I. M., Mulligan, W., Sharp, N.C.C.. & Urouhart, G. M. (1958) A field trial of a parasitic bronchitis vaccine. Veterinary record. 70, 451–454.Google Scholar
Miller, T. A. (1965) Studies in canine ancylostomiasis; double vaccination with X-irradiated Ancylostoma caninum larvae. Journal of the American Veterinary Medical Association, 146, 41–44.Google ScholarPubMed
Nansen, P. (1975) Resistance in cattle to Fasciola Hepatica Induced by X-ray attenuated larvae; results from a controlled field trial. Research in Veterinary Science, 10, 278–283.CrossRefGoogle Scholar
Schalm, O. W. (1965) Veterinary Haematology. Bailliere, Tindall and Cassell: London.Google Scholar
Taylor, M. G., James, E. R., Nelson, G. S., Bickle, Q. D., Dunne, D.W.. & Webbe, G. (1976) Immunization of sheep againest Schistosoma mansoni using either irradiated cercariae or irradiated schistosomula. Journal of Helminthology, 50, 1–9.CrossRefGoogle ScholarPubMed