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Preparation and characterization of glass–ceramic reinforced alginate scaffolds for bone tissue engineering

Published online by Cambridge University Press:  28 November 2019

Ashley Thomas Open the ORCID record for Ashley Thomas [Opens in a new window] ,
Eldin Johnson ,
Ashish K. Agrawal  and
Japes Bera Open the ORCID record for Japes Bera [Opens in a new window]
Ashley Thomas
Affiliation:
Department of Ceramic Engineering, National Institute of Technology, Rourkela, Odisha 769008, India
Eldin Johnson
Affiliation:
Department of Life Science, National Institute of Technology, Rourkela, Odisha 769008, India
Ashish K. Agrawal
Affiliation:
Technical Physics Division, Bhabha Atomic Research Center, Mumbai 400085, India
Japes Bera*
Affiliation:
Department of Ceramic Engineering, National Institute of Technology, Rourkela, Odisha 769008, India
*
a)Address all correspondence to this author. e-mail: jbera@nitrkl.ac.in
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Abstract

Bioactive glass–ceramic powder reinforced alginate scaffold has been successfully prepared and characterized for bone tissue engineering application. Glass-ceramic (GC) particles were synthesized through a sol–gel process. Alginate scaffolds containing different weight percentages of GC were fabricated through a freeze-drying technique. The composite scaffolds were characterized for phase analysis through X-ray powder diffraction and microstructure analysis through field emission scanning electron microscopy. The swelling behavior, degradation behavior, bioactivity, cell adhesion, and osteogenic potential of the fabricated scaffolds were evaluated. Microstructural analysis showed a highly porous behavior of the scaffold having a macroporous pore size. The composite scaffolds showed good bioactivity where GC induces apatite formation. The compressive strength of the scaffold was enhanced with GC addition due to the reinforcement of the alginate matrix. In vitro cell studies revealed that the composite scaffolds promoted cell adhesion, proliferation, and osteogenesis. Fabricated scaffolds are a promising biomaterial candidate for bone substitution because of their attractive properties.

Keywords

glass–ceramicalginatecomposite scaffoldfreeze-drying

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Type
Article
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Journal of Materials Research , Volume 34 , Issue 22 , 28 November 2019 , pp. 3798 - 3809
Copyright
Copyright © Materials Research Society 2019 

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