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Synthesis, surface modification, and applications of magnetic iron oxide nanoparticles

Published online by Cambridge University Press:  30 April 2019

Wenhui Ling Open the ORCID record for Wenhui Ling [Opens in a new window] ,
Mingyu Wang ,
Chunxia Xiong ,
Dengfeng Xie ,
Qiyu Chen ,
Xinyue Chu ,
Xiaoyan Qiu ,
Yuemin Li  and
Xiong Xiao
Wenhui Ling
Affiliation:
College of Animal Science and Technology, Southwest University, Chongqing 400715, China
Mingyu Wang
Affiliation:
College of Animal Science and Technology, Southwest University, Chongqing 400715, China
Chunxia Xiong
Affiliation:
College of Animal Science and Technology, Southwest University, Chongqing 400715, China
Dengfeng Xie
Affiliation:
College of Animal Science and Technology, Southwest University, Chongqing 400715, China
Qiyu Chen
Affiliation:
College of Animal Science and Technology, Southwest University, Chongqing 400715, China
Xinyue Chu
Affiliation:
College of Animal Science and Technology, Southwest University, Chongqing 400715, China
Xiaoyan Qiu
Affiliation:
College of Animal Science and Technology, Southwest University, Chongqing 400715, China
Yuemin Li
Affiliation:
College of Animal Science and Technology, Southwest University, Chongqing 400715, China
Xiong Xiao*
Affiliation:
College of Animal Science and Technology, Southwest University, Chongqing 400715, China
*
a)Address all correspondence to this author. e-mail: y1982@swu.edu.cn
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Abstract

Magnetic iron oxide nanoparticles (MIONPs) are particularly attractive in biosensor, antibacterial activity, targeted drug delivery, cell separation, magnetic resonance imaging tumor magnetic hyperthermia, and so on because of their particular properties including superparamagnetic behavior, low toxicity, biocompatibility, etc. Although many methods had been developed to produce MIONPs, some challenges such as severe agglomeration, serious oxidation, and irregular size are still faced in the synthesis of MIONPs. Thus, various strategies had been developed for the surface modification of MIONPs to improve the characteristics of them and obtain multifunctional MIONPs, which will widen the applicational scopes of them. Therefore, the processes, mechanisms, advances, advantages, and disadvantages of six main approaches for the synthesis of MIONPs; surface modification of MIONPs with inorganic materials, organic molecules, and polymer molecules; applications of MIONPs or modified MIONPs; the technical challenges of synthesizing MIONPs; and their limitations in biomedical applications were described in this review to provide the theoretical and technological guidance for their future applications.

Keywords

nanostructuresurface chemistrybiomedical

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Type
REVIEW
Information
Journal of Materials Research , Volume 34 , Issue 11: Focus Issue: (Nano)materials for Biomedical Applications , 14 June 2019 , pp. 1828 - 1844
Copyright
Copyright © Materials Research Society 2019 

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This section of Journal of Materials Research is reserved for papers that are reviews of literature in a given area.

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