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The effects of drugs on worm expulsion in the Nippostrongylus brasiliensis infected rat: a discussion of the interpretation of drug action

Published online by Cambridge University Press:  06 April 2009

R. Keller  and
Bridget M. Ogilvie
R. Keller*
Affiliation:
Immunobiology Research Group University of Zurich
Bridget M. Ogilvie
Affiliation:
National Institute for Medical Research Mill Hill, London
*
*Supported by the Swiss National Foundation for Scientific Research (Grant 5200.3).
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Extract

In rats treated with compound 48/80 or histamine, worm expulsion was inhibited. Treatment with a histidine decarboxylase inhibitor accelerated worm expulsion. Treatment with compound 48/80 elevates histamine and histidine decarboxylase levels and reduces circulating reagin titres. These results show that histamine is not responsible for worm expulsion.

Compounds such as isoprenaline and theophylline which increase cellular levels of cyclic 3′,5-AMP, prevented worm expulsion.

It is concluded that the evidence that amines are involved in worm expulsion needs reassessing and that cellular release mechanisms in general may be affected by drugs thought to act solely on amine release. In particular, the release of effector substances from sensitized lymphocytes on contact with antigen may be affected by these treatments.

The skilful technical assistance of Miss R. Keist and Miss I. Beeger is gratefully acknowledged. We thank Mr H. Berchtold, Biostatistisches Zentrum der Universität Zürich, for the statistical evaluation of the data.

Type
Research Article
Information
Parasitology , Volume 64 , Issue 2 , April 1972 , pp. 217 - 227
Copyright
Copyright © Cambridge University Press 1972

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