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X-ray powder diffraction data of lapatinib ditosylate monohydrate

Published online by Cambridge University Press:  29 February 2012

Peter Varlashkin
Peter Varlashkin*
Affiliation:
GlaxoSmithKline, 5 Moore Drive, Research Triangle Park, North Carolina 27707, USA
*
a)Electronic mail: peter.g.varlashkin@gsk.com
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Abstract

The room temperature powder pattern of lapatinib ditosylate monohydrate (active ingredient in Tykerb used to treat refractory breast cancer) was indexed and the cell from the single crystal X-ray diffraction structure was refined using the experimental capillary data. Unit-cell parameters for the orthorhombic compound with space group Pbca refined from powder diffraction data are a=9.6850±0.0009 Å, b=29.364±0.003 Å, and c=30.733±0.003 Å, α=β=γ=90°, z=8, V=8740.1 Å3. Values of 2θ, d, I, and Miller indices are reported.

Keywords

lapatiniblapatinib ditosylate monohydrateTykerbpowder diffraction datadrugbreast cancer

Information

Type
New Diffraction Data
Information
Powder Diffraction , Volume 24 , Issue 3 , September 2009 , pp. 250 - 253
Copyright
Copyright © Cambridge University Press 2009

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References

Boultif, A. (2005). “History of the dichotomy method for powder pattern indexing,” Powder Diffr. PODIE2 20, 284–287. 10.1154/1.2135307CrossRefGoogle Scholar
Boultif, A. and Louer, D. (2004). “Powder pattern indexing with the dichotomy method,” J. Appl. Crystallogr. JACGAR 37, 724–731. 10.1107/S0021889804014876CrossRefGoogle Scholar
Copley, R. “Single crystal X-ray structure” (private communication).Google Scholar
de Wolff, P. M. (1968). “A simplified criterion for the reliability of a powder pattern indexing,” J. Appl. Crystallogr. JACGAR 1, 108–113. 10.1107/S002188986800508XCrossRefGoogle Scholar
Johnston, S. R. D. and Leary, A. (2006). “Lapatinib: A novel EGFR/HER2 tyrosine kinase inhibitor for cancer,” Drugs Today (Barc) 42, 441–453. 10.1358/dot.2006.42.7.985637 CrossRefGoogle ScholarPubMed
Smith, G. S. and Snyder, R. L. (1979). “F(N): A criterion for rating powder diffraction patterns and evaluating the reliability of powder pattern indexing,” J. Appl. Crystallogr. JACGAR 12, 60–65. 10.1107/S002188987901178XCrossRefGoogle Scholar