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Can mesenchymal stem cells derived from adipose tissue and their conditioned medium improve ovarian functions? A mini-review

Published online by Cambridge University Press:  22 June 2022

Tayebe Pouryousefi-koodehi ,
Shika Shayegan ,
Soheyla Hashemi ,
Reza Arefnezhad ,
Hossein Roghani-Shahraki ,
Hossein Motedayyen ,
Neda Taghizabet  and
Fatemeh Rezaei-Tazangi Open the ORCID record for Fatemeh Rezaei-Tazangi [Opens in a new window]
Tayebe Pouryousefi-koodehi
Affiliation:
Department of Emergency, Milad Hospital, Tehran, Iran
Shika Shayegan
Affiliation:
Cyprus University of Health and Social Sciences, Faculty of Pharmacy, Kutlu Adali Boulevard, Guzelyurt, Cyprus
Soheyla Hashemi
Affiliation:
Stem Cell and Regenerative Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
Reza Arefnezhad*
Affiliation:
Department of Anatomy, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
Hossein Roghani-Shahraki
Affiliation:
Student Research Committee, Shiraz University of Medical Sciences, Shiraz, Iran
Hossein Motedayyen
Affiliation:
Autoimmune Diseases Research Center, Kashan University of Medical Sciences, Kashan, Iran
Neda Taghizabet
Affiliation:
Department of Anatomy, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
Fatemeh Rezaei-Tazangi
Affiliation:
Department of Anatomy, School of Medicine, Fasa University of Medical Sciences, Fasa, Iran
*
Author for correspondence: Reza Arefnezhad. Department of Anatomy, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran. E-mail: Arefnezhad@sums.ac.ir
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Summary

Stable ovarian function is a key factor in the performance of the reproductive system. In contrast, some ovarian function-related diseases, such as polycystic ovarian syndrome, premature ovarian failure (POF), and ovarian cancer, are the main cause of infertility and death of women around the world. Despite multiple attempts, there are no effective tools against these conditions; however, mesenchymal stem cell-based therapy, especially using adipose tissue, has attracted much attention in medicine in light of its advantages such as easy isolation and accessibility. Conversely, it has been suggested that MSC-conditioned medium (CM) can restore injured tissues and has high immunocompatibility. So, here, we will summarize the effects of administration of MSCs and CM derived from adipose tissue on ovarian functions and related diseases.

Keywords

Adipose tissue-derived mesenchymal stem cellConditioned mediumOvarian function

Information

Type
Review Article
Information
Zygote , Volume 30 , Issue 5 , October 2022 , pp. 589 - 592
Copyright
© The Author(s), 2022. Published by Cambridge University Press

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References

ArefNezhad, R., Motedayyen, H. and Mohammadi, A. (2021). Therapeutic aspects of mesenchymal stem cell-based cell therapy with a focus on human amniotic epithelial cells in multiple sclerosis: A mechanistic review. International Journal of Stem Cells, 14(3), 241–251. doi: 10.15283/ijsc21032 CrossRefGoogle ScholarPubMed
Cho, J., Kim, T. H., Seok, J., Jun, J. H., Park, H., Kweon, M., Lim, J. Y. and Kim, G. J. (2021). Vascular remodeling by placenta-derived mesenchymal stem cells restores ovarian function in ovariectomized rat model via the VEGF pathway. Laboratory Investigation; a Journal of Technical Methods and Pathology, 101(3), 304–317. doi: 10.1038/s41374-020-00513-1 CrossRefGoogle ScholarPubMed
Chu, Y., You, M., Zhang, J., Gao, G., Han, R., Luo, W., Liu, T., Zuo, J. and Wang, F. (2019). Adipose-derived mesenchymal stem cells enhance ovarian cancer growth and metastasis by increasing thymosin beta 4X-linked expression. Stem Cells International, 20, 25–38.Google Scholar
Chu, Y., Wang, Y., Li, K., Liu, M., Zhang, Y., Li, Y., Hu, X., Liu, C., Zhou, H., Zuo, J. and Peng, W. (2020). Human omental adipose-derived mesenchymal stem cells enhance autophagy in ovarian carcinoma cells through the STAT3 signalling pathway. Cellular Signalling, 69, 109549. doi: 10.1016/j.cellsig.2020.109549 CrossRefGoogle ScholarPubMed
Chugh, R. M., Park, H. S., Esfandyari, S., Elsharoud, A., Ulin, M. and Al-Hendy, A. (2021) Mesenchymal stem cell-conditioned media regulate steroidogenesis and inhibit androgen secretion in a PCOS cell model via BMP-2. International Journal of Molecular Sciences, 22(17), 9184–9195. doi: 10.3390/ijms22179184 CrossRefGoogle Scholar
Elfayomy, A. K., Almasry, S. M., El-Tarhouny, S. A. and Eldomiaty, M. A. (2016). Human umbilical cord blood-mesenchymal stem cells transplantation renovates the ovarian surface epithelium in a rat model of premature ovarian failure: Possible direct and indirect effects. Tissue and Cell, 48(4), 370–382. doi: 10.1016/j.tice.2016.05.001 CrossRefGoogle Scholar
Fan, C. W., Cieri-Hutcherson, N. E. and Hutcherson, T. C. (2021). Systematic review of black cohosh (Cimicifuga racemosa) for management of polycystic ovary syndrome-related infertility. Journal of Pharmacy Practice, 36, 8971900211012244. doi: 10.1177/08971900211012244 Google Scholar
Fu, X. F., He, Y. L., Xie, C. H. and Liu, W. (2008). Bone marrow mesenchymal stem cell transplantation improves ovarian function and structure in rats with chemotherapy-induced ovarian damage. Cytotherapy, 10(4), 353–363. doi: 10.1080/14653240802035926 CrossRefGoogle ScholarPubMed
Gunawardena, T. N. A., Rahman, M. T., Abdullah, B. J. J. and Abu Kasim, N. H. (2019). Conditioned media derived from mesenchymal stem cell cultures: The next generation for regenerative medicine. Journal of Tissue Engineering and Regenerative Medicine, 13(4), 569–586. doi: 10.1002/term.2806 CrossRefGoogle ScholarPubMed
He, Y., Chen, D., Yang, L., Hou, Q., Ma, H. and Xu, X. (2018). The therapeutic potential of bone marrow mesenchymal stem cells in premature ovarian failure. Stem Cell Research and Therapy, 9(1), 263. doi: 10.1186/s13287-018-1008-9 CrossRefGoogle ScholarPubMed
Javanmard, M. Z., Karimipour, M. and Pasdar, F. A. (2018). Conditioned medium derived from mesenchymal stem cells regenerates’ defected articular cartilage. Journal of the Urmia University of Medical Sciences, 29, 7–22.Google Scholar
Lee, S. H. (2021). Human adipose-derived stem cells’ paracrine factors in conditioned medium can enhance porcine oocyte maturation and subsequent embryo development. International Journal of Molecular Sciences, 22(2), 579–588. doi: 10.3390/ijms22020579 CrossRefGoogle ScholarPubMed
Liu, Y., He, Q. K., Xu, Z. R., Xu, C. L., Zhao, S. C., Luo, Y. S., Sun, X., Qi, Z. Q. and Wang, H. L. (2021). Thiamethoxam exposure induces endoplasmic reticulum stress and affects ovarian function and oocyte development in mice. Journal of Agricultural and Food Chemistry, 69(6), 1942–1952. doi: 10.1021/acs.jafc.0c06340 CrossRefGoogle ScholarPubMed
Nikanfar, S., Oghbaei, H., Rastgar Rezaei, Y. R., Zarezadeh, R., Jafari-Gharabaghlou, D., Nejabati, H. R., Bahrami, Z., Bleisinger, N., Samadi, N., Fattahi, A., Nouri, M. and Dittrich, R. (2021). Role of adipokines in the ovarian function: Oogenesis and steroidogenesis. Journal of Steroid Biochemistry and Molecular Biology, 209, 105852. doi: 10.1016/j.jsbmb.2021.105852 CrossRefGoogle ScholarPubMed
Rezaei-Tazangi, F., Roghani-Shahraki, H., Khorsand Ghaffari, M., Abolhasani Zadeh, F., Boostan, A., ArefNezhad, R. and Motedayyen, H. (2021). The therapeutic potential of common herbal and nano-based herbal formulations against ovarian cancer: New insight into the current evidence. Pharmaceuticals, 14(12), 1315–1325. doi: 10.3390/ph14121315 CrossRefGoogle ScholarPubMed
Shareghi-Oskoue, O., Aghebati-Maleki, L. and Yousefi, M. (2021). Transplantation of human umbilical cord mesenchymal stem cells to treat premature ovarian failure. Stem Cell Research and Therapy, 12(1), 454. doi: 10.1186/s13287-021-02529-w CrossRefGoogle ScholarPubMed
Takehara, Y., Yabuuchi, A., Ezoe, K., Kuroda, T., Yamadera, R., Sano, C., Murata, N., Aida, T., Nakama, K., Aono, F., Aoyama, N., Kato, K. and Kato, O. (2013). The restorative effects of adipose-derived mesenchymal stem cells on damaged ovarian function. Laboratory Investigation; A Journal of Technical Methods and Pathology, 93(2), 181–193. doi: 10.1038/labinvest.2012.167 CrossRefGoogle ScholarPubMed
Touboul, C., Lis, R., Al Farsi, H., Raynaud, C. M., Warfa, M., Althawadi, H., Mery, E., Mirshahi, M. and Rafii, A. (2013). Mesenchymal stem cells enhance ovarian cancer cell infiltration through IL6 secretion in an amniochorionic membrane based 3D model. Journal of Translational Medicine, 11, 28. doi: 10.1186/1479-5876-11-28 CrossRefGoogle Scholar
Xu, J. Y., Fan, Y. H., Geng, J. Z., Gao, N., Yu, F. H. and Xia, T. (2021). Application progress of acupuncture in treatment of ovarian hypofunction. TMR Non-Drug Therapy, 4(3), 16–28. doi: 10.53388/TMRND20210822036 CrossRefGoogle Scholar
Yin, J., Chang, H. M., Li, R. and Leung, P. C. K. (2021). Recent progress in the treatment of women with diminished ovarian reserve. Gynecology and Obstetrics Clinical Medicine, 1(4), 186–189. doi: 10.1016/j.gocm.2021.10.004 CrossRefGoogle Scholar
Yoon, S. Y. (2019). Mesenchymal stem cells for restoration of ovarian function. Clinical and Experimental Reproductive Medicine, 46(1), 1–7. doi: 10.5653/cerm.2019.46.1.1 CrossRefGoogle ScholarPubMed
Yu, L., Zhai, J., Wang, Y., Geng, Y., Chen, X., Wen, Y., Tang, H., Yu, R., Zhang, Y. and Liu, X. (2021). Exposure to N-monoacetyl-p-phenylenediamine impaired ovarian function in mice. Journal of Applied Toxicology, 41(12), 2031–2041. doi: 10.1002/jat.4183 CrossRefGoogle ScholarPubMed
Zhang, Y., Dong, W., Wang, J., Cai, J. and Wang, Z. (2017). Human omental adipose-derived mesenchymal stem cell-conditioned medium alters the proteomic profile of epithelial ovarian cancer cell lines in vitro . OncoTargets and Therapy, 10, 1655–1663. doi: 10.2147/OTT.S129502 CrossRefGoogle ScholarPubMed
Zhang, W., Torres-Rojas, C., Yue, J. and Zhu, B. M. (2021). Adipose-derived stem cells in ovarian cancer progression, metastasis, and chemoresistance. Experimental Biology and Medicine, 246(16), 1810–1815. doi: 10.1177/15353702211023846 CrossRefGoogle Scholar
Zhao, Y. X., Chen, S. R., Su, P. P., Huang, F. H., Shi, Y. C., Shi, Q. Y. and Lin, S. (2019). Using mesenchymal stem cells to treat female infertility: An update on female reproductive diseases. Stem Cells International, 20, 19–28.Google Scholar
Zhou, F., Song, Y., Liu, X., Zhang, C., Li, F., Hu, R., Huang, Y., Ma, W., Song, K. and Zhang, M. (2021). Si-Wu-Tang facilitates ovarian function through improving ovarian microenvironment and angiogenesis in a mouse model of premature ovarian failure. Journal of Ethnopharmacology, 280, 114431. doi: 10.1016/j.jep.2021.114431 CrossRefGoogle Scholar