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7 - Emission tomography in adult ADHD

from Section 2 - Insights into the pathophysiology of ADHD in adults

Published online by Cambridge University Press:  04 April 2011

By
Mitul A. Mehta  and
Johanna Krause
Edited by
Jan K. Buitelaar ,
Cornelis C. Kan  and
Philip Asherson
Jan K. Buitelaar
Affiliation:
Radboud Universiteit Nijmegen Medical Center
Cornelis C. Kan
Affiliation:
Radboud Universiteit Nijmegen Medical Centerr
Philip Asherson
Affiliation:
Institute of Psychiatry, London
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Summary

This chapter reviews emission tomography studies in attention-deficit hyperactivity disorder (ADHD) that address the neurobiology of this disorder and treatment effects. It examines the potential for these imaging techniques to help undercover possible mechanisms underlying the behavioral and cognitive changes that follow treatment. Single photon emission computed tomography (SPECT) and positron emission tomography (PET) studies of cerebral perfusion and dopamine synthesis, release, and receptors have shown clear sensitivity to ADHD, with differential measurements across all modalities. Striatal markers of perfusion and functional activation in adults are proving important in understanding functional deficits in ADHD. In addition, striatal dopamine markers potentially relevant in mediating differences in cognition and personality differ in both children and adults with ADHD. The most recent studies have confirmed that dopaminergic markers are indeed valuable targets for understanding the neurobiology of ADHD.
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ADHD in Adults
Characterization, Diagnosis, and Treatment
 , pp. 75 - 90
Publisher: Cambridge University Press
Print publication year: 2011

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