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31 - Embryo and fetal research

Published online by Cambridge University Press:  30 October 2009

Ronald M. Green
Affiliation:
Dartmouth University, Hanover USA
Peter A. Singer
Affiliation:
University of Toronto
A. M. Viens
Affiliation:
University of Oxford
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Summary

The year is 2016. J and K meet with their pediatrician to discuss whether their 11-year-old daughter, L, should undergo a newly available course of stem cell therapy to cure her type 1 juvenile diabetes. Left untreated, L's illness could lead to blindness, life-threatening circulation problems in her extremities, and, perhaps, early death. The therapy that L's parents and her pediatrician are contemplating requires careful HLA (immunological compatibility) matching with one of the thousands of human embryonic stem cell (hESC) lines identified in an international registry. These were created over the previous decade from frozen human embryos remaining from infertility procedures and were donated to research or therapy by their progenitors. A matching population of specially created pancreatic stem cells could be made from one of these lines and infused into L to remedy her insulin deficit. While many parents would leap at this life-saving opportunity, J and K – and their physician – face a moral quandary. They are all devout Roman Catholics and share their church's view that human life must be regarded as sacred from the moment of conception. They view the destruction of a human embryo for stem cell research or therapy as equivalent to killing a human being. The physician explains to J and K that the frozen human embryos used to create hESC lines were slated for destruction. Is it not better, he asks, that such embryos at least be used to save lives? But J and K are also aware of their church's moral teaching that “one should not do evil in order that good may result.”

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Publisher: Cambridge University Press
Print publication year: 2008

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References

Bliton, M. (2005). Parental hope confronting scientific uncertainty: a test of ethics in maternal–fetal surgery for spina bifida. Clin Obstet Gynecol 48: 595–607.CrossRefGoogle ScholarPubMed
Chambers, G. M., Ho, M. T., and Sullivan, E. A. (2006). Assisted reproductive technology treatment costs of a live birth: an age-stratified cost–outcome study of treatment in Australia. Med J Aust 184: 155–8 (http://www.mja.com.au/public/rop/chambers/cha10890_fm.html).Google ScholarPubMed
Chung, Y. (2006). Embryonic and extraembryonic stem cell lines derived from single mouse blastomeres. Nature 439: 216–19.CrossRefGoogle ScholarPubMed
Cook, G. (2004). New technique eyes in stem-cell debate. Boston Globe, 21 November, A1.Google Scholar
Wert, G., Berghmans, R. L., Boer, G. J., et al. (2002). Ethical guidance on human embryonic and fetal tissue transplantation: a European overview. Med Health Care Philos 5: 79–90.CrossRefGoogle Scholar
Dreifus, C. (2006). At Harvard's stem cell center, the barriers run deep and wide. New York Times, 24 January.
Freed, C. R., Greene, P. E., Breeze, R. E., et al. (2001). Transplantation of embryonic dopamine neurons for severe Parkinson's disease. N Engl J Med 344: 710–19.CrossRefGoogle ScholarPubMed
Gratton B., for the European Group on Ethics in Science and New Technologies to the European Commission. (2002). Survey on the National Regulations in the European Union Regarding Research on Human Embryos. Brussels: European Union. http://ec.europa.eu/european_group_ethics/publications/docs/nat_reg_en.pdf.
Green, R. M. (2001). The Human Embryo Research Debates: Bioethics in the Vortex of Controversy. New York: Oxford University Press.Google Scholar
Green, R. M. (2002a). Research involving fetuses and in vitro fertilization. In Institutional Review Board: Management and Function, ed. Amdur, R. J. and Bankert, E. A.. Sudbury, MA: Jones and Bartlett, pp. 373–9.Google Scholar
Green, R. M. (2002b). Benefiting from “evil”; an incipient moral problem in human stem cell research. Bioethics 16: 544–56.CrossRefGoogle Scholar
Hoffman, W. (2004). Stem cell policy: world stem cell map. Delaware, MN: MBBNet (http://mbbnet.umn.edu/scmap.html).
Howe, E. G. (2003). Ethical issue in fetal surgery. Semin Perinatol 27: 446–57.CrossRefGoogle ScholarPubMed
Hulse, C. (2006). Senate approves a stem-cell bill; veto is expected. New York Times, 19 July.
Human Fertilisation and Embryology Authority (2003). Code of Practice, 6th edn, 10.2. London: Human Fertilisation and Embryology Authority (http://www.hfea.gov.uk/HFEAPublications/CodeofPractice/Code%20of%).Google Scholar
Jones, H. W. Jr. and Schnom, J. A. (2001). Multiple pregnancies: a call for action. Fert Steril 75: 11–17.CrossRefGoogle ScholarPubMed
Kiessling, A. A. (2001). In the stem-cell debate, new concepts need new words. Nature 413: 453.CrossRefGoogle ScholarPubMed
Kovalesky, G., Rinaudo, P., and Coutifaris, C. (2003). Do assisted reproductive technologies cause adverse fetal outcomes?Fert Steril 79: 1270–2.CrossRefGoogle Scholar
Lanza, R. M., Caplan, A. L., Silver, R. M., et al. (2000). The ethical validity of using nuclear transfer In human transplantation. JAMA 284: 3175–9.CrossRefGoogle ScholarPubMed
Melton, D., Daley, G., and Jennings, C. G. (2004). Altered nuclear transfer in stem-cell research: a flawed proposal. N Engl J Med 351: 2791–2.CrossRefGoogle ScholarPubMed
Neumann, P. J., Gharib, S. D., and Weinstein, M. C. (1994). The cost of a successful delivery with in vitro fertilization. N Engl J Med 331: 239–43.CrossRefGoogle ScholarPubMed
NIH Human Embryo Research Panel (1994). The Human Embryo Research Report, Vols. I and II. Bethesda, MD: National Institutes of Health (http://ospp.od.nih.gov/pdf/volume1_revised.pdf).Google Scholar
Pontifical Academy for Life (2000). Declaration on the Production and the Scientific and Therapeutic Use of Human Embryonic Stem Cells. Rome: The Curia (http://www.vatican.va/roman_curia/pontifical_academies/acdlife/documents/rc_pa_acdlife_doc_20000824_cellule–staminali_en.html).Google Scholar
Powell, K. (2003). Seeds of doubt. Nature 422: 656–8.CrossRefGoogle Scholar
President's Council on Bioethics (2004). Report of the President's Council on Bioethics: Monitoring Stem Cell Research. Washington, DC: Government Printing Office (http://bioethics.gov/reports/stemcell/index.html).Google Scholar
President's Council on Bioethics (2005). Alternative Sources of Pluripotent Stem Cells: A White Paper. DC: Government Printing Office. http://www.bioethics.gov/reports/white_paper/index.html.Google Scholar
Rebar, R. (2002). ASRM statement on risk of cancer associated with fertility drugs. Available online at: http://www.inciid.org/article.php?cat=infertility&id=146.
Rossing, M. A., Daling, J. R., Weiss, N. J., et al. (1994). Ovarian tumors in a cohort or infertile women. N Engl J Med 331: 771–6.CrossRefGoogle ScholarPubMed
Sacred Congregation for the Doctrine of the Faith (1974). Declaration on Procured Abortion. Rome: The Curia (http://www.vatican.va/roman_curia/congregations/cfaith/documents/rc_con_cfaith_doc_19741118_ declaration-abortion_en.html).Google Scholar
Shamblott, M. J., Axelman, J., Wang, S., et al. (1998). Derivation of pluripotent stem cells from cultured human primordial germ cells. Proc Natl Acad Sci 95: 13726–31.CrossRefGoogle ScholarPubMed
Tauer, C. A. (2004). Embryo research. In Encyclopedia of Bioethics, 3rd edn, ed. Post, S. G.. New York: Macmillan Reference USA, pp. 712–22.Google Scholar
Thomson, J. A., Itskovitz-Eldor, J., Shapiro, S. S., et al. (1998). Embryonic stem cell lines derived from human blastocysts. Science 282: 1145–7.CrossRefGoogle ScholarPubMed
US Department of Health and Human Services (2005). Code of Federal Regulations Title 45, Vol. 46. 204(b,c,e), 46.203(b). Washington, DC: Government Printing Office.Google Scholar
Walters, L. (2004). Human embryonic stem cell research: an intercultural perspective. Kennedy Inst Ethics J 14: 3–38.CrossRefGoogle Scholar
Warren, M. A. (1997). Moral Status: Obligations to Persons and Other Living Things. New York: Oxford University Press.Google Scholar

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