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Chapter 10 - Features of Imaging in Transgender Persons

from Section B - Practicing Transgynecology

Published online by Cambridge University Press:  22 December 2022

Mick van Trotsenburg
Affiliation:
Sigmund Freud PrivatUniversität, Wien
Rixt A. C. Luikenaar
Affiliation:
Rebirth Health Center, Utah
Maria Cristina Meriggiola
Affiliation:
Università di Bologna
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Summary

Medical imaging serves an essential role in the care continuum for transgender and gender diverse patients. In addition to evaluation of general medical conditions, imaging may be used in the transgender population for cancer screening and for evaluation after gender-affirming therapies. Collaboration among gynecologists, radiology professionals, and patients is essential to ensure diagnostic utility of imaging and a positive imaging experience.

Type
Chapter
Information
Context, Principles and Practice of TransGynecology
Managing Transgender Patients in ObGyn Practice
, pp. 72 - 81
Publisher: Cambridge University Press
Print publication year: 2022

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References

Stowell, JT, Grimstad, FW, Kirkpatrick, DL, et al. Imaging findings in transgender patients after gender-affirming surgery. Radiographics 2019;39(5):13681392.Google Scholar
Stowell, JT, Garner, HW, Herrmann, S, Tilson, K, Stanborough, RO. Bone health of transgender adults: what the radiologist needs to know. Skeletal Radiol 2020;49(10):15251537.CrossRefGoogle ScholarPubMed
Grimstad, FW, Stowell, JT, Gaddis, M. Survey of experiences of transgender and gender nonbinary patients during imaging encounters and opportunities for improvement. Am J Roentgenol 2020;215(5):11361142.Google Scholar
Kirkpatrick, DL, Stowell, J, Grimstad, F, et al. Creating a transgender-inclusive interventional radiology department. J Vasc Interv Radiol 2019;30(6):928931.Google Scholar
Goldberg, JE, Moy, L, Rosenkrantz, AB. Assessing transgender patient care and gender inclusivity of breast imaging facilities across the United States. J Am Coll Radiol 2018;15(8):11641172.Google Scholar
Wierckx, K, Gooren, L, T’Sjoen, G. Clinical review: breast development in trans women receiving cross-sex hormones. J Sex Med 2014;11(5):12401247.CrossRefGoogle ScholarPubMed
Maycock, LB, Kennedy, HP. Breast care in the transgender individual. J Midwifery Women’s Health 2014;59(1):7481.CrossRefGoogle ScholarPubMed
Maglione, KD, Margolies, L, Jaffer, S, et al. Breast cancer in male-to-female transsexuals: use of breast imaging for detection. Am J Roentgenol 2014;203(6):W735W740.Google Scholar
Lemmo, G, Garcea, N, Corsello, S, et al. Breast fibroadenoma in a male-to-female transsexual patient after hormonal treatment. Eur J Surg Suppl. 2003;(588):6971.Google Scholar
Phillips, J, Fein-Zachary, VJ, Mehta, TS, et al. Breast imaging in the transgender patient. Am J Roentgenol 2014;202(5):11491156.Google Scholar
Reisman, T, Goldstein, Z. Case report: induced lactation in a transgender woman. Transgend Health 2018;3(1):2426.CrossRefGoogle Scholar
Weyers, S, Villeirs, G, Vanherreweghe, E, et al. Mammography and breast sonography in transsexual women. Eur J Radiol 2010;74(3):508513.Google Scholar
Freer, PE. Mammographic breast density: impact on breast cancer risk and implications for screening. Radiographics 2015;35(2):302315.Google Scholar
Brown, GR, Jones, KT. Incidence of breast cancer in a cohort of 5,135 transgender veterans. Breast Cancer Res Treat 2015;149(1):191198.Google Scholar
de Blok, CJM, Wiepjes, CM, Nota, NM, et al. Breast cancer risk in transgender people receiving hormone treatment: nationwide cohort study in the Netherlands. Br Med J 2019;365:1652.CrossRefGoogle ScholarPubMed
Gooren, L, Bowers, M, Lips, P, Konings, IR. Five new cases of breast cancer in transsexual persons. Andrologia 2015;47(10):12021205.Google Scholar
Hartley, RL, Stone, JP, Temple-Oberle, C. Breast cancer in transgender patients: a systematic review. Part 1: male to female. Eur J Surg Oncol 2018;44(10):14551462.CrossRefGoogle ScholarPubMed
Joint, R, Chen, ZE, Cameron, S. Breast and reproductive cancers in the transgender population: a systematic review. BJOG 2018;125(12):15051512.Google Scholar
McFarlane, T, Zajac, JD, Cheung, AS. Gender-affirming hormone therapy and the risk of sex hormone-dependent tumours in transgender individuals: a systematic review. Clin Endocrinol 2018;89(6):700711.CrossRefGoogle ScholarPubMed
Corman, V, Potorac, I, Manto, F, et al. Breast cancer in a male-to-female transsexual patient with a BRCA2 mutation. Endocrine-Related Cancer 2016;23(5):391397.CrossRefGoogle Scholar
Narayan, A, Lebron-Zapata, L, Morris, E. Breast cancer screening in transgender patients: findings from the 2014 BRFSS survey. Breast Cancer Res Treat 2017;166(3):875879.CrossRefGoogle ScholarPubMed
Bazzi, AR, Whorms, DS, King, DS, Potter, J. Adherence to mammography screening guidelines among transgender persons and sexual minority women. Am J Public Health 2015;105(11):23562358.CrossRefGoogle ScholarPubMed
Huang, S-Y, Zhang, M, David, M. Radiology’s engagement with transgender breast imaging: review of radiology practice websites and publications. J Breast Imaging 2020;2(2):147151.CrossRefGoogle Scholar
Mainiero, MB, Moy, L, Baron, P, et al. ACR appropriateness criteria® breast cancer screening. J Am Coll Radiol 2017;14(11s):S383S390.CrossRefGoogle ScholarPubMed
Shah, AT, Jankharia, BB. Imaging of common breast implants and implant-related complications: a pictorial essay. Indian J Radiol Imaging 2016;26(2):216225.Google ScholarPubMed
Parikh, U, Mausner, E, Chhor, CM, et al. Breast imaging in transgender patients: what the radiologist should know. Radiographics 2020;40(1):1327.Google Scholar
Stone, JP, Hartley, RL, Temple-Oberle, C. Breast cancer in transgender patients: a systematic review. Part 2: female to male. Eur J Surg Oncol 2018;44(10):14631468.Google Scholar
Torous, VF, Schnitt, SJ. Histopathologic findings in breast surgical specimens from patients undergoing female-to-male gender reassignment surgery. Mod Pathol 2019;32(3):346353.CrossRefGoogle ScholarPubMed
East, EG, Gast, KM, Kuzon, WM Jr., et al. Clinicopathological findings in female-to-male gender-affirming breast surgery. Histopathology 2017;71(6):859865.CrossRefGoogle ScholarPubMed
Grynberg, M, Fanchin, R, Dubost, G, et al. Histology of genital tract and breast tissue after long-term testosterone administration in a female-to-male transsexual population. Reproductive BioMedicine Online 2010;20(4):553558.CrossRefGoogle Scholar
Bentz, E-K, Pils, D, Bilban, M, et al. Gene expression signatures of breast tissue before and after cross-sex hormone therapy in female-to-male transsexuals. Fertil Steril 2010;94(7):26882696.Google Scholar
Salvi, S, Bonafè, M, Bravaccini, S. Androgen receptor in breast cancer: a wolf in sheep’s clothing? A lesson from prostate cancer. Semin Cancer Biol 2020;60:132137.CrossRefGoogle ScholarPubMed
Wolter, A, Diedrichson, J, Scholz, T, Arens-Landwehr, A, Liebau, J. Sexual reassignment surgery in female-to-male transsexuals: an algorithm for subcutaneous mastectomy. J Plast Reconstr Aesthet Surg 2015;68(2):184191.Google Scholar
Center of Excellence for Transgender Health DoF, Community Medicine UoCSF. Guidelines for the Primary and Gender-Affirming Care of Transgender and Gender Nonbinary People; 2nd ed.Google Scholar
Woitek, R, Pfeiler, G, Farr, A, et al. MRI-based quantification of residual fibroglandular tissue of the breast after conservative mastectomies. Eur J Radiol 2018;104:17.CrossRefGoogle ScholarPubMed
Perrone, AM, Cerpolini, S, Maria Salfi, NC, et al. Effect of long-term testosterone administration on the endometrium of female‐to‐male (FtM) transsexuals. J Sex Med 2009;6(11):31933200.Google Scholar
Grimstad, FW, Fowler, KG, New, EP, et al. Uterine pathology in transmasculine persons on testosterone: a retrospective multicenter case series. Am J Obstet Gynecol 2019;220(3):257.e251–257.CrossRefGoogle ScholarPubMed
Futterweit, W, Deligdisch, L. Histopathological effects of exogenously administered testosterone in 19 female to male transsexuals. J Clin Endocrinol Metab 1986;62(1):1621.Google Scholar
Grimstad, FW, Boskey, E, Grey, M. New-onset abdominopelvic pain after initiation of testosterone therapy among trans-masculine persons: a community-based exploratory survey. LGBT Health 2020;7(5):248253.Google Scholar
Chadha, S, Pache, TD, Huikeshoven, JM, Brinkmann, AO, van der Kwast, TH. Androgen receptor expression in human ovarian and uterine tissue of long-term androgen-treated transsexual women. Hum Pathol 1994;25(11):11981204.Google Scholar
Ikeda, K, Baba, T, Noguchi, H, et al. Excessive androgen exposure in female-to-male transsexual persons of reproductive age induces hyperplasia of the ovarian cortex and stroma but not polycystic ovary morphology. Hum Reprod 2013;28(2):453461.Google Scholar
Caanen, MR, Schouten, NE, Kuijper, EAM, et al. Effects of long-term exogenous testosterone administration on ovarian morphology, determined by transvaginal (3D) ultrasound in female-to-male transsexuals. Hum Reprod 2017;32(7):14571464.CrossRefGoogle ScholarPubMed
Grimstad, FW, Fowler, KG, New, EP, et al. Ovarian histopathology in transmasculine persons on testosterone: a multicenter case series. J Sex Med 2020;17(9):18071818.Google Scholar
Robbins, JB, Sadowski, EA, Maturen, KE, et al. ACR appropriateness criteria® abnormal uterine bleeding. J Am Coll Radiol 2020;17(11s):S336S345.Google Scholar
Bhosale, PR, Javitt, MC, Atri, M, et al. ACR appropriateness criteria® acute pelvic pain in the reproductive age group. Ultrasound Q 2016;32(2):108115.Google Scholar
American Institute of Ultrasound in Medicine (AIUM). Practice parameter for the performance of an ultrasound examination of the female pelvis. J Ultrasound Med 2020;39(5):E17–23.Google Scholar
Mueller, A, Kiesewetter, F, Binder, H, Beckmann, MW, Dittrich, R. Long-term administration of testosterone undecanoate every 3 months for testosterone supplementation in female-to-male transsexuals. J Clin Endocrinol Metab 2007;92(9):34703475.CrossRefGoogle ScholarPubMed
Mueller, A, Haeberle, L, Zollver, H, et al. Effects of intramuscular testosterone undecanoate on body composition and bone mineral density in female-to-male transsexuals. J Sex Med 2010;7(9):31903198.Google Scholar
den Heijer, M, Bakker, A, Gooren, L. Long-term hormonal treatment for transgender people. Br Med J 2017;359:j5027.CrossRefGoogle ScholarPubMed
Braun, H, Nash, R, Tangpricha, V, et al. Cancer in transgender people: evidence and methodological considerations. Epidemiol Rev 2017;39(1):93107.Google Scholar
Grimstad, FW, Fowler, KG, New, EP, et al. Ovarian histopathology in transmasculine persons on testosterone: a multicenter case series. J Sex Med 2020;17(9):18071818.Google Scholar
Urban, RR, Teng, NNH, Kapp, DS. Gynecologic malignancies in female-to-male transgender patients: the need of original gender surveillance. Am J Obstet Gynecol 2011;204(5):e9e12.CrossRefGoogle Scholar
Hage, JJ, Dekker, JJML, Karim, RB, Verheijen, RHM, Bloemena, E. Ovarian cancer in female-to-male transsexuals: report of two cases. Gynecol Oncol 2000;76(3):413415.Google Scholar
Dizon, DS, Tejada-Berges, T, Koelliker, S, Steinhoff, M, Granai, CO. Ovarian cancer associated with testosterone supplementation in a female-to-male transsexual patient. Gynecol Obstet Invest 2006;62(4):226228.Google Scholar
Trum, HW, Hoebeke, P, Gooren, LJ. Sex reassignment of transsexual people from a gynecologist’s and urologist’s perspective. Acta Obstetricia et Gynecologica Scandinavica 2015;94(6):563567.CrossRefGoogle ScholarPubMed
Weyers, S, Decaestecker, K, Verstraelen, H, et al. Clinical and transvaginal sonographic evaluation of the prostate in transsexual women. Urology 2009;74(1):191196.Google Scholar
Gooren, L, Morgentaler, A. Prostate cancer incidence in orchidectomised male-to-female transsexual persons treated with oestrogens. Andrologia 2014;46(10):11561160.Google Scholar
Deebel, NA, Morin, JP, Autorino, R, et al. Prostate cancer in transgender women: incidence, etiopathogenesis, and management challenges. Urology 2017;110:166171.CrossRefGoogle ScholarPubMed
Jin, B, Turner, L, Walters, AW, Handelsman, DJ. Androgen or estrogen effects on human prostate. J Clin Endocrinol Metab 1996;81(12):42904295.Google Scholar
Zhang, SJ, Qian, HN, Zhao, Y, et al. Relationship between age and prostate size. Asian J Androl 2013;15(1):116120.Google Scholar
van Kesteren, P, Meinhardt, W, van der Valk, P, et al. Effects of estrogens only on the prostates of aging men. J Urol 1996;156(4):13491353.Google Scholar
Coakley, FV, Oto, A, Alexander, LF, et al. ACR appropriateness criteria® prostate cancer: pre-treatment detection, surveillance, and staging. J Am Coll Radiol 2017;14(5s):S245S257.Google Scholar
Gawlitza, J, Reiss-Zimmermann, M, Thörmer, G, et al. Impact of the use of an endorectal coil for 3 T prostate MRI on image quality and cancer detection rate. Scientific Rep 2017;7:40640.Google Scholar
Jindarak, S, Nilprapha, K, Atikankul, T, et al. Spermatogenesis abnormalities following hormonal therapy in transwomen. Biomed Res Int 2018;2018:7919481.CrossRefGoogle ScholarPubMed
Kent, MA, Winoker, JS, Grotas, AB. Effects of feminizing hormones on sperm production and malignant changes: microscopic examination of post orchiectomy specimens in transwomen. Urology 2018;121:9396.Google Scholar
Schneider, F, Neuhaus, N, Wistuba, J, et al. Testicular functions and clinical characterization of patients with gender dysphoria (GD) undergoing sex reassignment surgery (SRS). J Sex Med 2015;12(11):21902200.CrossRefGoogle ScholarPubMed
Jiang, DD, Swenson, E, Mason, M, et al. Effects of estrogen on spermatogenesis in transgender women. Urology 2019;132:117122.CrossRefGoogle ScholarPubMed
Wolf-Gould, CS, Wolf-Gould, CH. A transgender woman with testicular cancer: a new twist on an old problem. LGBT Health 2016;3(1):9095.Google Scholar
Chandhoke, G, Shayegan, B, Hotte, SJ. Exogenous estrogen therapy, testicular cancer, and the male to female transgender population: a case report. J Med Case Rep 2018;12(1):373.Google Scholar
Kvach, EJ, Hyer, JS, Carey, JC, Bowers, M. Testicular seminoma in a transgender woman: a case report. LGBT Health 2019;6(1):4042.CrossRefGoogle Scholar
Fighera, TM, Ziegelmann, PK, Rasia da Silva, T, Spritzer, PM. Bone mass effects of cross-sex hormone therapy in transgender people: updated systematic review and meta-analysis. J Endocr Soc 2019;3(5):943964.Google Scholar
Wiepjes, CM, de Jongh, RT, de Blok, CJ, et al. Bone safety during the first ten years of gender-affirming hormonal treatment in transwomen and transmen. J Bone Miner Res 2019;34(3):447454.CrossRefGoogle ScholarPubMed
Wiepjes, CM, de Blok, CJ, Staphorsius, AS, et al. Fracture risk in trans women and trans men using long-term gender-affirming hormonal treatment: a nationwide cohort study. J Bone Miner Res 2020;35(1):6470.Google Scholar
Rosen, HN, Hamnvik, OR, Jaisamrarn, U, et al. Bone densitometry in transgender and gender non-conforming (TGNC) individuals: 2019 ISCD official position. J Clin Densitom 2019;22(4):544553.Google Scholar
Fighera, TM, da Silva, ED, Borba, GDS, Spritzer, PM. Does (mis)use of industrial liquid silicone implants interfere with bone mineral density in transgender women? Arch Osteoporos 2020;15(1):149.Google Scholar
Coombes, GB, Reiser, J, Paradinas, FJ, Burn, I. An androgen-associated hepatic adenoma in a trans-sexual. Br J Surg 1978;65(12):869870.Google Scholar
Bird, D, Vowles, K, Anthony, PP. Spontaneous rupture of a liver cell adenoma after long term methyltestosterone: report of a case successfully treated by emergency right hepatic lobectomy. Br J Surg 1979;66(3):212213.Google Scholar

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