This chapter reviews the evidence for Valentinian and Marcionite movements in mid to late second-century Alexandria. It analyzes the Excerpts from Theodotus made by Clement of Alexandria to retell the Valentinian story of creation and redemption as it was known in Alexandria. Apelles is recorded to have come to Alexandria at some point between 150 and 180 ce. The fragments of Apelles reveal several attempts to modify elements of Marcionite thought (e.g., the oneness of God and the compound nature of Jesus’s body) according to Valentinian emphases. Although the evidence is thin, both Celsus and Origen confirm that Marcionite and Valentinian Christians were present in Alexandria and flourished there into the third century.