Skip to main content Accessibility help

We use cookies to distinguish you from other users and to provide you with a better experience on our websites. Close this message to accept cookies or find out how to manage your cookie settings.

Close cookie message
×
Hostname: page-component-848d4c4894-5nwft Total loading time: 0 Render date: 2024-06-12T10:58:04.451Z Has data issue: false hasContentIssue false

Chapter 46 - Fetal Tumors: Clinical Management

from Fetal Tumors

Published online by Cambridge University Press:  21 October 2019

By
Sundeep G. Keswani  and
Timothy M. Crombleholme
Edited by
Mark D. Kilby ,
Anthony Johnson  and
Dick Oepkes
Mark D. Kilby
Affiliation:
University of Birmingham
Anthony Johnson
Affiliation:
University of Texas Medical School at Houston
Dick Oepkes
Affiliation:
Leids Universitair Medisch Centrum
Get access

Summary

Significant advances in prenatal imaging have allowed us to diagnose tumors in utero more accurately. These prenatal diagnostic capabilities have significantly increased the benefits for parents, the fetal patient, and the perinatal team who take care of these delicate patients. For the parents of a fetus diagnosed with a neoplastic tissue growth, it affords them more comprehensive prenatal counseling so that they are aware of what to expect for the duration of the pregnancy, and to help them prepare for the challenges the baby will face at the perinatal stage and beyond. For the fetus, prenatal diagnosis has enabled us to identify a subset of these babies who have historically faced a very poor prognosis and may benefit from an in utero intervention that could potentially salvage the pregnancy. Lastly, for the perinatal team prenatal diagnosis helps identify those high-risk patients who will endure significant perinatal challenges and thus empower them to ensure that the baby is delivered in the appropriate setting, at an optimal gestational age, and when indicated with advanced delivery techniques, such as the ex utero intrapartum treatment (EXIT) procedure, to afford the best possible outcome for the most critical patients.

Type
Chapter
Information
Fetal Therapy
Scientific Basis and Critical Appraisal of Clinical Benefits
 , pp. 480 - 493
Publisher: Cambridge University Press
Print publication year: 2020

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Oka, K, Okane, M, Okuno, S, et al. Congenital cervical immature teratoma arising in the left lobe of the thyroid gland. APMIS. 2007; 115: 75–9.Google Scholar
Hodges, MM, Crombleholme, TM, Marwan, AI, et al. Massive facial teratoma managed with the ex utero intrapartum treatment (EXIT) procedure and use of 3-dimensional printed model for planning of staged debulking. J Pediatr Surg. 2017; 17: 15–19.Google Scholar
Kelly, MF, Berenholz, L, Rizzo, KA, et al. Approach for oxygenation of the newborn with airway obstruction due to a cervical mass. Ann Otol Rhinol Laryngol. 1990; 99: 179–82.Google Scholar
Hubbard, AM, Crombleholme, TM, Adzick, NS. Prenatal MRI evaluation of giant neck masses in preparation for the fetal exit procedure. Am J Perinatol. 1998; 15: 253–7.Google Scholar
Thawani, JP, Randazzo, MJ, Singh, N, Pisapia, JM, Abdullah, KG, Storm, PB. Management of giant cervical teratoma with intracranial extension diagnosed in utero. J Neurol Surg Rep. 2016; 77: e118–120.Google Scholar
Trecet, JC, Claramunt, V, Larraz, J, et al. Prenatal ultrasound diagnosis of fetal teratoma of the neck. J Clin Ultrasound. 1984; 12: 509–11.Google Scholar
Ryan, G, Somme, S, Crombleholme, TM. Airway compromise in the fetus and neonate: Prenatal assessment and perinatal management. Semin Fetal Neonatal Med. 2016; 21: 230–9.Google Scholar
Marwan, A, Crombleholme, TM. The EXIT procedure: principles, pitfalls, and progress. Semin Pediatr Surg. 2006; 15: 107–15.Google Scholar
Tonni, G, De Felice, C, Centini, G, Ginanneschi, C. Cervical and oral teratoma in the fetus: a systematic review of etiology, pathology, diagnosis, treatment and prognosis. Arch Gynecol Obstet. 2010; 282: 355–61.CrossRefGoogle ScholarPubMed
Omissakin, OO, Kache, SA, Ajike, SO. Congenital epulis: a report of twin cases and review of the literature. Int J Med Biomed. 2016; 5: 130–4.Google Scholar
Vazquez, E, Castellote, A, Mayolas, N, et al. Congenital tumours involving the head, neck and central nervous system. Pediatr Radiol. 2009; 39: 1158–72.Google Scholar
Holley, DG, Martin, GR, Brenner, JI, et al. Diagnosis and management of fetal cardiac tumors: a multicenter experience and review of published reports. J Am Coll Cardiol. 1995; 26: 516–20.Google Scholar
Groves, AM, Fagg, NL, Cook, AC, Allan, LD. Cardiac tumours in intrauterine life. Arch Dis Child. 1992; 67: 1189–92.Google Scholar
Roach, ES, Sparagana, SP. Diagnosis of tuberous sclerosis complex. J Child Neurol. 2004; 19: 643–9.Google Scholar
Green, KW, Bors-Koefoed, R, Pollack, P, Weinbaum, PJ. Antepartum diagnosis and management of multiple fetal cardiac tumors. J Ultrasound Med. 1991; 10: 697–9.Google Scholar
Mehta, AV. Rhabdomyoma and ventricular preexcitation syndrome: a report of two cases and review of literature. Am J Dis Child. 1993; 147: 669–71.Google Scholar
Barnes, BT, Procaccini, D, Crino, J, et al. Maternal sirolimus therapy for fetal rhabdomyomas. N Engl J Med. 2018; 378: 1844–5.Google Scholar
Azizkhan, RG, Crombleholme, TM. Congenital cystic lung disease: contemporary antenatal and postnatal management. Pediatr Surg Int. 2008; 24: 643–57.Google Scholar
Oepkes, D, Devlieger, R, Lopriore, E, Klumper, FJ. Successful ultrasound-guided laser treatment of fetal hydrops caused by pulmonary sequestration. Ultrasound Obstet Gynecol. 2007; 29: 457–9.Google Scholar
Coleman, AM, Merrow, AC, Crombleholme, TM, Jaekle, R, Lim, FY. Fetal MRI of torsed bronchopulmonary sequestration with tension hydrothorax and hydrops in a twin gestation. Fetal Diagn Ther. 2016; 40: 156–60.Google Scholar
Witlox, RS, Lopriore, E, Oepkes, D. Prenatal interventions for fetal lung lesions. Prenatal Diagn. 2011; 31: 628–36.Google Scholar
Ruano, R, da Silva, MM, Salustiano, EM, et al. Percutaneous laser ablation under ultrasound guidance for fetal hyperechogenic microcystic lung lesions with hydrops : a single center cohort and literature review. Prenatal Diagn. 2012; 32: 1127–32.Google Scholar
Stocker, JT, Madewell, JE, Drake, RM. Congenital cystic adenomatoid malformation of the lung. Classification and morphologic spectrum. Hum Pathol. 1977; 8: 155–71.CrossRefGoogle ScholarPubMed
Diamond, IR, Wales, PW, Smith, SD, Fecteau, A. Survival after CCAM associated with ascites: a report of a case and review of the literature. J Pediatr Surg. 2003; 38: E1–3.Google Scholar
Crombleholme, TM, Coleman, B, Hedrick, H, et al. Cystic adenomatoid malformation volume ratio predicts outcome in prenatally diagnosed cystic adenomatoid malformation of the lung. J Pediatr Surg. 2002; 37: 331–8.Google Scholar
Makin, E, Davenport, M. Fetal and neonatal liver tumours. Early Hum Dev. 2010; 86: 637.Google Scholar
Isaacs, H Jr. Fetal and neonatal hepatic tumors. J Pediatr Surg. 2007; 42: 1797–803.Google Scholar
Kamata, S, Nose, K, Sawai, T, et al. Fetal mesenchymal hamartoma of the liver: report of a case. J Pediatr Surg. 2003; 38: 639–41.CrossRefGoogle ScholarPubMed
Foucar, E, Williamson, RA, Yiu-Chiu, V, Varner, MW, Kay, BR. Mesenchymal hamartoma of the liver identified by fetal sonography. AJR Am J Roentgenol. 1983; 140: 970–2.Google Scholar
Jones, VS, Cohen, RC. Atypical congenital mesoblastic nephroma presenting in the perinatal period. Pediatr Surg Int. 2007; 23: 205–9.Google Scholar
Linam, LE, Yu, X, Calvo-Garcia, MA, et al. Contribution of magnetic resonance imaging to prenatal differential diagnosis of renal tumors: report of two cases and review of the literature. Fetal Diagn Ther. 2010; 28: 100–8.Google Scholar
Powis, M. Neonatal renal tumours. Early Hum Dev. 2010; 86: 607–12.Google Scholar
Leclair, M-D, El-Ghoneimi, A, Audry, G, et al. The outcome of prenatally diagnosed renal tumors. J Urol. 2005; 173: 186–9.CrossRefGoogle ScholarPubMed
Grundy, RG, Pritchard, J, Baraitser, M, Risdon, A, Robards, M. Perlman and Wiedemann–Beckwith syndromes: two distinct conditions associated with Wilms’ tumour. Eur J Pediatr. 1992; 151: 895–8.CrossRefGoogle ScholarPubMed
Nuchtern, JG. Perinatal neuroblastoma. Semin Pediatr Surg. 2006; 15: 10–16.CrossRefGoogle ScholarPubMed
Athanassiadou, F, Kourti, M, Papageorgiou, T, Drevelegas, A, Zaramboukas, T. Prenatally diagnosed cystic neuroblastoma. Pediatr Blood Cancer. 2005; 44: 290–1.Google Scholar
Jennings, RW, LaQuaglia, MP, Leong, K, Hendren, WH, Adzick, NS. Fetal neuroblastoma: prenatal diagnosis and natural history. J Pediatr Surg. 1993; 28: 1168–74.Google Scholar
Askin, J, Geschickter, C. Neuroblastoma of the adrenal in children. J Pediatr. 1935; 7: 157–8.CrossRefGoogle Scholar
Forrester, MB, Merz, RD. Descriptive epidemiology of teratoma in infants, Hawaii, 1986–2001. Paediatr Perinat Epidemiol. 2006; 20: 54–8.Google Scholar
Altman, RP, Randolph, JG, Lilly, JR. Sacrococcygeal teratoma: American Academy of Pediatrics Surgical Section Survey – 1973. J Pediatr Surg. 1974; 9: 389–98.Google Scholar
Chervenak, FA, Isaacson, G, Touloukian, R, et al. Diagnosis and management of fetal teratomas. Obstet Gynecol. 1985; 66: 666–71.Google Scholar
Danzer, E, Hubbard, AM, Hedrick, HL, et al. Diagnosis and characterization of fetal sacrococcygeal teratoma with prenatal MRI. AJR Am J Roentgenol. 2006; 187: W350–6.Google Scholar
Flake, AW, Harrison, MR, Adzick, NS, Laberge, JM, Warsof, SL. Fetal sacrococcygeal teratoma. J Pediatr Surg. 1986; 21: 563–6.Google Scholar
Hedrick, HL, Flake, AW, Crombleholme, TM, et al. Sacrococcygeal teratoma: prenatal assessment, fetal intervention, and outcome. J Pediatr Surg. 2004; 39: 430–8.CrossRefGoogle ScholarPubMed
Adzick, NS, Harrison, MR. The unborn surgical patient. Curr Probl Surg. 1994; 31: 1–68.CrossRefGoogle ScholarPubMed
Bahlmann, F, Wellek, S, Reinhardt, I, et al. Reference values of fetal aortic flow velocity waveforms and associated intra-observer reliability in normal pregnancies. Ultrasound Obstet Gynecol. 2001; 17: 42–9.Google Scholar
el-Qarmalawi, MA, Saddik, M, el Abdel Hadi, F, Muwaffi, R, Nageeb, K. Diagnosis and management of fetal sacrococcygeal teratoma. Int J Gynaecol Obstet. 1990; 31: 275–81.Google Scholar
Adzick, NS, Crombleholme, TM, Morgan, MA, Quinn, TM. A rapidly growing fetal teratoma. Lancet. 1997; 349: 538.Google Scholar
Sananes, N, Javadian, P, Schwach Werneck Britto, I, et al. Technical aspects and effectiveness of percutaneous fetal therapies for large sacrococcygeal teratomas: cohort study and literature review. Ultrasound Obstet Gynecol. 2016; 47: 712–19.Google Scholar
Van Mieghem, T, Al-Ibrahim, A, Deprest, J, et al. Minimally invasive therapy for fetal sacrococcygeal teratoma: case series and systematic review of the literature. Ultrasound Obstet Gynecol. 2014; 43: 611–19.Google Scholar
Cowles, RA, Stolar, CJH, Kandel, JJ, et al. Preoperative angiography with embolization and radiofrequency ablation as novel adjuncts to safe surgical resection of a large, vascular sacrococcygeal teratoma. Pediatr Surg Int. 2006; 22: 554–6.CrossRefGoogle ScholarPubMed
Misra, D, Pritchard, J, Drake, DP, Kiely, EM, Spitz, L. Markedly improved survival in malignant sacro-coccygeal teratomas – 16 years’ experience. Eur J Pediatr Surg. 1997; 7: 152–5.Google Scholar

Save book to Kindle

To save this book to your Kindle, first ensure coreplatform@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about saving to your Kindle.

Note you can select to save to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be saved to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

Find out more about the Kindle Personal Document Service.

Available formats
×

Save book to Dropbox

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Dropbox.

Available formats
×

Save book to Google Drive

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Google Drive.

Available formats
×