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1 - The Central Dogma

Published online by Cambridge University Press:  05 June 2012

Rex A. Dwyer
Affiliation:
The BioAlgorithmic Consultancy
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Summary

DNA and RNA

Each of us has observed physical and other similarities among members of human families. While some of these similarities are due to the common environment these families share, others are inherited, that is, passed on from parent to child as part of the reproductive process. Traits such as eye color and blood type and certain diseases such as red–green color blindness and Huntington's disease are among those known to be heritable. In humans and all other nonviral organisms, heritable traits are encoded and passed on in the form of deoxyribonucleic acid, or DNA for short. The DNA encoding a single trait is often referred to as a gene. Most human DNA encodes not traits that distinguish one human from another but rather traits we have in common with all other members of the human family. Although I do not share my adopted children's beautiful brown eyes and black hair, we do share more than 99.9% of our DNA. Speaking less sentimentally, all three of us share perhaps 95% of our DNA with the chimpanzees.

DNA consists of long chains of molecules of the modified sugar deoxyribose, to which are joined the nucleotides adenine, cytosine, guanine, and thymine. The scientific significance of these names is minimal – guanine, for example, is named after the bird guano from which it was first isolated – and we will normally refer to these nucleotides or bases by the letters A, C, G, and T. For computational purposes, a strand of DNA can be represented by a string of As, Cs, Gs, and Ts.

Type
Chapter
Information
Genomic Perl
From Bioinformatics Basics to Working Code
, pp. 1 - 15
Publisher: Cambridge University Press
Print publication year: 2002

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  • The Central Dogma
  • Rex A. Dwyer, The BioAlgorithmic Consultancy
  • Book: Genomic Perl
  • Online publication: 05 June 2012
  • Chapter DOI: https://doi.org/10.1017/CBO9781139164764.002
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  • The Central Dogma
  • Rex A. Dwyer, The BioAlgorithmic Consultancy
  • Book: Genomic Perl
  • Online publication: 05 June 2012
  • Chapter DOI: https://doi.org/10.1017/CBO9781139164764.002
Available formats
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  • The Central Dogma
  • Rex A. Dwyer, The BioAlgorithmic Consultancy
  • Book: Genomic Perl
  • Online publication: 05 June 2012
  • Chapter DOI: https://doi.org/10.1017/CBO9781139164764.002
Available formats
×