Focusing on Donne’s view of natural theology, especially from 1614 onward, this chapter makes two central claims. First, considering Donne biographically, I argue that while there is important continuity in Donne’s career (insofar as he engages with the book of nature throughout), his vocational turn in the years 1611–1614 refocuses, reshapes, and intensifies that engagement: the skeptical and noncommittal attitude toward apprehension of the divine in the sensible world that can be traced in the Songs and Sonnets is replaced by a clearer and altogether more hopeful tone in the Essayes, with Donne further developing his insights about the book of nature in his sermons and the Devotions. Second, I argue that Donne’s insights deserve to be included in historical studies of natural theology in the early seventeenth century and his exclusion has been partly facilitated by scholarly emphasis on his earlier work, although this is changing.