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40 - Tumors of the Liver

from SECTION V - OTHER CONDITIONS AND ISSUES IN PEDIATRIC HEPATOLOGY

Published online by Cambridge University Press:  18 December 2009

By
Dolores López-Terrada M.D., Ph.D.  and
Milton J. Finegold M.D.
Edited by
Frederick J. Suchy ,
Ronald J. Sokol  and
William F. Balistreri
Dolores López-Terrada M.D., Ph.D.
Affiliation:
Assistant Professor, Department of Pathology, Baylor College of Medicine, Houston, Texas; Pathologist, Department of Pathology, Texas Children's Hospital, Houston, Texas
Milton J. Finegold M.D.
Affiliation:
Professor, Department of Pathology and Pediatrics, Baylor College of Medicine, Houston, Texas; Head of Pathology Department, Texas Children's Hospital, Houston, Texas
Frederick J. Suchy
Affiliation:
Mount Sinai School of Medicine, New York
Ronald J. Sokol
Affiliation:
University of Colorado, Denver
William F. Balistreri
Affiliation:
University of Cincinnati
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Summary

The clinical presentation of the vast majority of liver tumors in children is an asymptomatic palpable mass. The majority of malignancies are large and may be difficult to excise without prior chemotherapy because the liver's functional capacity is rarely compromised by underlying cirrhosis. Involvement of the perihilar segments or intrahepatic dissemination may necessitate transplantation. The vascularity of the liver and ready access of cancer cells to hepatic veins make pulmonary metastasis at presentation relatively common. Therefore, knowledge of precursor conditions and screening can be lifesaving.

Approximately two thirds of all liver masses occurring in children are malignant. Twenty separate series totaling 1972 primary benign and malignant liver tumors in children from 1956 to 2001 included hepatoblastomas (HB; 37%), hepatocellular carcinomas (HCC; 21%), benign vascular tumors (15%), mesenchymal hamartomas and sarcomas (8%), adenomas and focal nodular hyperplasia (7.5%), and other tumors (4%) [1, 2] (Table 40.1).

EPIDEMIOLOGY

Approximately 1.1% of all childhood tumors in the United States are malignant liver tumors according to the Surveillance, Epidemiology, and End Results (SEER) program cancer registries, with an annual incidence rate of 1.8 cases per million children younger than 15 years [3]. Of 123 children registered with malignant liver tumors in 2000, 80% had HB and they accounted for 91% of primary hepatic malignancy cases in children aged less than 5 years [4]. Primary liver tumors accounted for 6–8% of congenital tumors in Isaacs's review of 265 neoplasms discovered within 30 days of birth [5].

Type
Chapter
Information
Liver Disease in Children , pp. 943 - 974
Publisher: Cambridge University Press
Print publication year: 2007

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References

Weinberg, A G, Finegold, M J. Primary hepatic tumors of childhood. Hum Pathol 1983;14:512–37.CrossRefGoogle ScholarPubMed
Stocker, J T. Hepatic tumors in children. 2nd ed. Philadelphia: Lippincott, Williams and Wilkins, 2001.Google ScholarPubMed
See the Surveillance Epidemiology and End Results Web site, National Cancer Institute: http://seer. cancer.gov. (Accessed November 15, 2006.)
Darbari, A, Sabin, K M, Shapiro, C N, Schwarz, K B. Epidemiology of primary hepatic malignancies in U.S. children. Hepatology 2003;38:560–6.CrossRefGoogle ScholarPubMed
Isaacs, H Jr. Neoplasms in infants: a report of 265 cases. Pathol Annu 1983;18:165–214.Google ScholarPubMed
Tsai, H L, Liu, C S, Chin, T W, Wei, C F. Hepatoblastoma and hepatocellular carcinoma in children. J Chin Med Assoc 2004;6783–8.Google ScholarPubMed
Finegold, M J. Tumors of the liver. Semin Liver Dis 1994;14:270–81.CrossRefGoogle ScholarPubMed
Bortolasi, L, Marchiori, L, Dal Dosso, I. Hepatoblastoma in adult age: a report of two cases. Hepatogastroenterology 1996;43:1073–8.Google ScholarPubMed
Yamazaki, M, Ryu, M, Okazumi, S. Hepatoblastoma in an adult. A case report and clinical review of literatures. Hepatol Res 2004;30:182–8.CrossRefGoogle Scholar
Kasper, H U, Longerich, T, Stippel, D L. Mixed hepatoblastoma in an adult. Arch Pathol Lab Med 2005;129:234–7.Google Scholar
Kenney, L B, Miller, B A, Ries, L A. Increased incidence of cancer in infants in the U.S.: 1980–1990. Cancer 1998;82:1396–400.Google Scholar
El-Serag, H B, Davila, J A, Petersen, N J, McGlynn, K A. The continuing increase in the incidence of hepatocellular carcinoma in the United States: an update. Ann Intern Med 2003;139:817–23.CrossRefGoogle ScholarPubMed
Pontisso, P, Morsica, G, Ruvoletto, M G. Latent hepatitis B virus infection in childhood hepatocellular carcinoma. Analysis by polymerase chain reaction. Cancer 1992;69:2731–5.3.0.CO;2-9>CrossRefGoogle ScholarPubMed
Cheah, P L, Looi, L M, Lin, H P, Yap, S F. A case of childhood hepatitis B virus infection related primary hepatocellular carcinoma with short malignant transformation time. Pathology 1991;23:66–8.CrossRefGoogle ScholarPubMed
Chang, M H. Decreasing incidence of hepatocellular carcinoma among children following universal hepatitis B immunization. Liver Int 2003;23:309–14.CrossRefGoogle ScholarPubMed
Montesano, R. Hepatitis B immunization and hepatocellular carcinoma: The Gambia Hepatitis Intervention Study. J Med Virol 2002;67:444–6.CrossRefGoogle ScholarPubMed
Katzenstein, H M, Krailo, M D, Malogolowkin, M H. Fibrolamellar hepatocellular carcinoma in children and adolescents. Cancer 2003;97:2006–12.CrossRefGoogle ScholarPubMed
Oue, T, Kubota, A, Okuyama, H. Hepatoblastoma in children of extremely low birth weight: a report from a single perinatal center. J Pediatr Surg 2003;38:134–7; discussion 134–7.CrossRefGoogle ScholarPubMed
Ikeda, H, Hachitanda, Y, Tanimura, M. Development of unfavorable hepatoblastoma in children of very low birth weight: results of a surgical and pathologic review. Cancer 1998;82:1789–96.3.0.CO;2-Z>CrossRefGoogle ScholarPubMed
Tanimura, M, Matsui, I, Abe, J. Increased risk of hepatoblastoma among immature children with a lower birth weight. Cancer Res 1998;58:3032–5.Google ScholarPubMed
Reynolds, M. Current status of liver tumors in children. Semin Pediatr Surg 2001;10:140–5.CrossRefGoogle ScholarPubMed
Kapfer, S A, Petruzzi, M J, Caty, M G. Hepatoblastoma in low birth weight infants: an institutional review. Pediatr Surg Int 2004;20:753–6.CrossRefGoogle Scholar
Ansell, P, Mitchell, C D, Roman, E. Relationships between perinatal and maternal characteristics and hepatoblastoma: a report from the UKCCS. Eur J Cancer 2004;41:741–8.CrossRefGoogle Scholar
Buckley, J D, Sather, H, Ruccione, K. A case–control study of risk factors for hepatoblastoma. A report from the Childrens Cancer Study Group. Cancer 1989;64:1169–76.3.0.CO;2-I>CrossRefGoogle ScholarPubMed
Satge, D, Sasco, A J, Little, J. Antenatal therapeutic drug exposure and fetal/neonatal tumours: review of 89 cases. Paediatr Perinat Epidemiol 1998;12:84–117.CrossRefGoogle ScholarPubMed
Sorahan, T, Lancashire, R J. Parental cigarette smoking and childhood risks of hepatoblastoma: OSCC data. Br J Cancer 2004;90:1016–18.CrossRefGoogle ScholarPubMed
Pang, D, McNally, R, Birch, J M. Parental smoking and childhood cancer: results from the United Kingdom Childhood Cancer Study. Br J Cancer 2003;88:373–81.CrossRefGoogle ScholarPubMed
Vileisis, R A, Sorensen, K, Gonzalez-Crussi, F, Hunt, C E. Liver malignancy after parenteral nutrition. J Pediatr 1982;100:88–90.CrossRefGoogle ScholarPubMed
Patterson, K, Kapur, S P, Chandra, R S. Hepatocellular carcinoma in a noncirrhotic infant after prolonged parenteral nutrition. J Pediatr 1985;106:797–800.CrossRefGoogle Scholar
DeBaun, M R, Tucker, M A. Risk of cancer during the first four years of life in children from The Beckwith–Wiedemann Syndrome Registry. J Pediatr 1998;132:398–400.CrossRefGoogle ScholarPubMed
Clericuzio, C L, Chen, E, McNeil, D E. Serum alpha-fetoprotein screening for hepatoblastoma in children with Beckwith–Wiedemann syndrome or isolated hemihyperplasia. J Pediatr 2003;143:270–2.CrossRefGoogle ScholarPubMed
Cooper, W N, Luharia, A, Evans, G A. Molecular subtypes and phenotypic expression of Beckwith–Wiedemann syndrome. Eur J Hum Genet 2005;13:1025–32.CrossRefGoogle ScholarPubMed
Gracia Bouthelier, R, Lapunzina, P. Follow-up and risk of tumors in overgrowth syndromes. J Pediatr Endocrinol Metab 2005;18 Suppl 1:1227–35.Google ScholarPubMed
Li, M, Shuman, C, Fei, Y L. GPC3 mutation analysis in a spectrum of patients with overgrowth expands the phenotype of Simpson–Golabi–Behmel syndrome. Am J Med Genet 2001;102:161–8.3.0.CO;2-O>CrossRefGoogle Scholar
Buonuomo,, P.S, Ruggiero, A, Vasta, I, Attina, G, Riccardi, R, Zampino, G. Second case of hepatoblastoma in a young patient with Simpson-Golabi-Behmel syndrome. Pediatr Hematol Oncol 2005;22:623–8.CrossRefGoogle Scholar
Rodriguez-Criado,, G, Magano,, L, Segovia,, M. Clinical and molecular studies on two further families with Simpson–Golabi–Behmel syndrome. Am J Med Genet A 2005;138:272–7.CrossRefGoogle Scholar
Cohen, MM Jr. Beckwith–Wiedemann syndrome: historical, clinicopathological, and etiopathogenetic perspectives. Pediatr Dev Pathol 2005;8:287–304.CrossRefGoogle ScholarPubMed
Kingston, J E, Draper, G J, Mann, J R. Hepatoblastoma and polyposis coli. Lancet 1982;1:457.CrossRefGoogle ScholarPubMed
Giardiello, F M, Petersen, G M, Brensinger, J D. Hepatoblastoma and APC gene mutation in familial adenomatous polyposis. Gut 1996;39:867–9.CrossRefGoogle ScholarPubMed
Aretz, S, Koch, A, Uhlhaas, S. Should children at risk for familial adenomatous polyposis be screened for hepatoblastoma and children with apparently sporadic hepatoblastoma be screened for APC germline mutations?Pediatr Blood Cancer 2006;47:811–18.CrossRefGoogle ScholarPubMed
Oda, H, Imai, Y, Nakatsuru, Y. Somatic mutations of the APC gene in sporadic hepatoblastomas. Cancer Res 1996;56:3320–3.Google ScholarPubMed
Thomas, D, Pritchard, J, Davidson, R. Familial hepatoblastoma and APC gene mutations: renewed call for molecular research. Eur J Cancer 2003;39:2200–4.CrossRefGoogle ScholarPubMed
Weinberg, A G, Mize, C E, Worthen, H G. The occurrence of hepatoma in the chronic form of hereditary tyrosinemia. J Pediatr 1976;88:434–8.CrossRefGoogle ScholarPubMed
Demers, S I, Russo, P, Lettre, F, Tanguay, R M. Frequent mutation reversion inversely correlates with clinical severity in a genetic liver disease, hereditary tyrosinemia. Hum Pathol 2003;34:1313–20.CrossRefGoogle Scholar
Lindstedt, S, Holme, E, Lock, E A. Treatment of hereditary tyrosinaemia type I by inhibition of 4-hydroxyphenylpyruvate dioxygenase. Lancet 1992;340:813–17.CrossRefGoogle ScholarPubMed
Holme, E, Lindstedt, S. Nontransplant treatment of tyrosinemia. Clin Liver Dis 2000;4:805–14.CrossRefGoogle ScholarPubMed
Bianchi, L. Glycogen storage disease I and hepatocellular tumours. Eur J Pediatr 1993;152 Suppl 1:S63–70.CrossRefGoogle ScholarPubMed
Coire, C I, Qizilbash, A H, Castelli, M F. Hepatic adenomata in type Ia glycogen storage disease. Arch Pathol Lab Med 1987;111:166–9.Google ScholarPubMed
Siciliano, M, Candia, E, Ballari,, S. Hepatocellular carcinoma complicating liver cirrhosis in type IIIa glycogen storage disease. J Clin Gastroenterol 2000;31:80–2.CrossRefGoogle ScholarPubMed
Kaufman, S S, Wood, R P, Shaw, B W. Hepatocarcinoma in a child with the Alagille syndrome. Am J Dis Child 1987;141:698–700.Google Scholar
Rabinovitz, M, Imperial, J C, Schade, R R, Thiel, D H. Hepatocellular carcinoma in Alagille's syndrome: a family study. J Pediatr Gastroenterol Nutr 1989;8:26–30.CrossRefGoogle ScholarPubMed
Taat, F, Bosman, D K, Aronson, D C. Hepatoblastoma in a girl with biliary atresia: coincidence or co-incidence. Pediatr Blood Cancer 2004;43:603–5.CrossRefGoogle ScholarPubMed
Richter, A, Grabhorn, E, Schulz, A. Hepatoblastoma in a child with progressive familial intrahepatic cholestasis. Pediatr Transplant 2005;9:805–8.CrossRefGoogle Scholar
Lederman, S M, Martin, E C, Laffey, K T, Lefkowitch, J H. Hepatic neurofibromatosis, malignant schwannoma, and angiosarcoma in von Recklinghausen's disease. Gastroenterology 1987;92:234–9.CrossRefGoogle ScholarPubMed
Geoffroy-Perez, B, Janin, N, Ossian, K. Cancer risk in heterozygotes for ataxia-telangiectasia. Int J Cancer 2001;93:288–93.CrossRefGoogle ScholarPubMed
Tsui, W M, Colombari, R, Portmann, B C. Hepatic angiomyolipoma: a clinicopathologic study of 30 cases and delineation of unusual morphologic variants. Am J Surg Pathol 1999;23:34–48.CrossRefGoogle ScholarPubMed
Fricke, B L, Donnelly, L F, Casper, K A, Bissler, J J. Frequency and imaging appearance of hepatic angiomyolipomas in pediatric and adult patients with tuberous sclerosis. AJR Am J Roentgenol 2004;182:1027–30.CrossRefGoogle ScholarPubMed
Ucar C, Caliskan U, Toy H, Gunel E. Hepatoblastoma in a child with neurofibromatosis type I. Pediatr Blood Cancer 2005, Nov. 10; Epub ahead of print.
Abbondanzo, S L, Manz, H J, Klappenbach, R S, Gootenberg, J E. Hepatocellular carcinoma in an 11-year-old girl with Fanconi's anemia. Report of a case and review of the literature. Am J Pediatr Hematol Oncol 1986;8:334–7.CrossRefGoogle Scholar
Touraine, R L, Bertrand, Y, Foray, P. Hepatic tumours during androgen therapy in Fanconi anaemia. Eur J Pediatr 1993;152:691–3.CrossRefGoogle ScholarPubMed
Ishak, K G, Goodman, Z D, Stocker, J T. Tumor of the liver and intrahepatic bile ducts. Washington, D.C.: Armed Forces Institute of Pathology, 2001.Google Scholar
Stringer, M D. Liver tumors. Semin Pediatr Surg 2001;9:196–208.CrossRefGoogle Scholar
Jung, S E, Kim, K H, Kim, M Y. Clinical characteristics and prognosis of patients with hepatoblastoma. World J Surg 2001;25:126–30.CrossRefGoogle ScholarPubMed
Dasgupta, D, Guthrie, A, McClean, P. Liver transplantation for a hilar inflammatory myofibroblastic tumor. Pediatr Transplant 2005;8:517–21.CrossRefGoogle Scholar
Horowitz, M E, Etcubanas, E, Webber, B L. Hepatic undifferentiated (embryonal) sarcoma and rhabdomyosarcoma in children. Results of therapy. Cancer 1987;59:396–402.3.0.CO;2-W>CrossRefGoogle Scholar
Mueller, B U, Mulliken, J B. The infant with a vascular tumor. Semin Perinatol 1999;23:332–40.CrossRefGoogle ScholarPubMed
Shiozawa, Y, Fujita, H, Fujimura, J. A fetal case of transient abnormal myelopoiesis with severe liver failure in Down syndrome: prognostic value of serum markers. Pediatr Hematol Oncol 2004;21:273–8.CrossRefGoogle ScholarPubMed
Arshad, R R, Woo, S Y, Abbassi, V. Virilizing hepatoblastoma: precocious sexual development and partial response of pulmonary metastases to cis-platinum. CA Cancer J Clin 1982;32:293–300.CrossRefGoogle ScholarPubMed
Galifer, R B, Sultan, C, Margueritte, G, Barneon, G. Testosterone-producing hepatoblastoma in a 3-year-old boy with precocious puberty. J Pediatr Surg 1985;20:713–14.CrossRefGoogle Scholar
Watanabe, I, Yamaguchi, M, Kasai, M. Histologic characteristics of gonadotropin-producing hepatoblastoma: a survey of seven cases from Japan. J Pediatr Surg 1987;22:406–11.CrossRefGoogle ScholarPubMed
Heerema-McKenney, A, Leuschner, I, Smith, N. Nested stromal epithelial tumor of the liver: six cases of a distinctive pediatric neoplasm with frequent calcifications and association with cushing syndrome. Am J Surg Pathol 2005;29:10–20.CrossRefGoogle ScholarPubMed
Hill, D A, Swanson, P E, Anderson, K. Desmoplastic nested spindle cell tumor of liver: report of four cases of a proposed new entity. Am J Surg Pathol 2005;29:1–9.CrossRefGoogle ScholarPubMed
Huang, K, Lin, S. Nationwide vaccination: a success story in Taiwan. Vaccine 2000;18 Suppl 1:S35–8.CrossRefGoogle ScholarPubMed
Moritake, H, Taketomi, A, Kamimura, S. Renin-producing hepatoblastoma. J Pediatr Hematol Oncol 2000;22:78–80.CrossRefGoogle ScholarPubMed
Nickerson, H J, Silberman, T L, McDonald, T P. Hepatoblastoma, thrombocytosis, and increased thrombopoietin. Cancer 1980;45:315–17.3.0.CO;2-W>CrossRefGoogle ScholarPubMed
Shafford, E A, Pritchard, J. Extreme thrombocytosis as a diagnostic clue to hepatoblastoma. Arch Dis Child 1993;69:171.CrossRefGoogle ScholarPubMed
Enjolras, O, Wassef, M, Mazoyer, E. Infants with Kasabach–Merritt syndrome do not have “true” hemangiomas. J Pediatr 1997;130:631–40.CrossRefGoogle ScholarPubMed
Ravindra, K V, Guthrie, J A, Woodley, H. Preoperative vascular imaging in pediatric liver transplantation. J Pediatr Surg 40:643–7.CrossRef
Foulner, D, Cremin, B. Childhood hepatocellular carcinoma and hepatoblastoma: integrated sonography and dynamic CT. Australas Radiol 1991;35:346–9.CrossRefGoogle ScholarPubMed
King, S J, Babyn, P S, Greenberg, M L. Value of CT in determining the resectability of hepatoblastoma before and after chemotherapy. Am J Roentgenol 1993;160:793–8.CrossRefGoogle ScholarPubMed
Schweinitz, D, Gluer, S, Mildenberger, H. Liver tumors in neonates and very young infants: diagnostic pitfalls and therapeutic problems. Eur J Pediatr Surg 1995;5:72–6.CrossRefGoogle Scholar
Hoffer, F A. Magnetic resonance imaging of abdominal masses in the pediatric patient. Semin Ultrasound CT MR 2005;26:212–23.CrossRefGoogle ScholarPubMed
Philip, I, Shun, A, McCowage, G, Howman-Giles, R. Positron emission tomography in recurrent hepatoblastoma. Pediatr Surg Int 21:341–5.CrossRef
Begemann, M, Trippett, T M, Lis, E, Antunes, N L. Brain metastases in hepatoblastoma. Pediatr Neurol 2004;30:295–7.CrossRefGoogle ScholarPubMed
Perilongo, G, Brown, J, Shafford, E. Hepatoblastoma presenting with lung metastases: treatment results of the first cooperative, prospective study of the International Society of Paediatric Oncology on childhood liver tumors. Cancer 2000;89:1845–53.3.0.CO;2-D>CrossRefGoogle ScholarPubMed
Archer, D, Babyn, P, Gilday, D, Greenberg, M A. Potentially misleading bone scan findings in patients with hepatoblastoma. Clin Nucl Med 1993;18:1026–31.CrossRefGoogle ScholarPubMed
Abramson, L P, Pillai, S, Acton, R. Successful orthotopic liver transplantation for treatment of a hepatic yolk sac tumor. J Pediatr Surg 2005;40:1185–7.CrossRefGoogle ScholarPubMed
Blohm, M E, Vesterling-Horner, D, Calaminus, G, Gobel, U. Alpha 1-fetoprotein (AFP) reference values in infants up to 2 years of age. Pediatr Hematol Oncol 1998;15:135–42.CrossRefGoogle ScholarPubMed
Schneider, D T, Calaminus, G, Gobel, U. Diagnostic value of alpha 1-fetoprotein and beta-human chorionic gonadotropin in infancy and childhood. Pediatr Hematol Oncol 2001;18:11–26.CrossRefGoogle ScholarPubMed
Vaughan, W G, Sanders, D W, Grosfeld, J L. Favorable outcome in children with Beckwith–Wiedemann syndrome and intraabdominal malignant tumors. J Pediatr Surg 1995;30:1042–4; discussion 1044–5.CrossRefGoogle ScholarPubMed
Pompili, M, Rapaccini, G L, Covino, M. Prognostic factors for survival in patients with compensated cirrhosis and small hepatocellular carcinoma after percutaneous ethanol injection therapy. Cancer 2001;92:126–35.3.0.CO;2-V>CrossRefGoogle ScholarPubMed
Tornout, J M, Buckley, J D, Quinn, J J. Timing and magnitude of decline in alpha-fetoprotein levels in treated children with unresectable or metastatic hepatoblastoma are predictors of outcome: a report from the Children's Cancer Group. J Clin Oncol 1997;15:1190–7.CrossRefGoogle ScholarPubMed
Boman, F, Bossard, C, Fabre, M. Mesenchymal hamartomas of the liver may be associated with increased serum alpha foetoprotein concentrations and mimic hepatoblastomas. Eur J Pediatr Surg 2004;14:63–6.Google ScholarPubMed
Stocker, J T, Ishak, K G. Mesenchymal hamartoma of the liver: report of 30 cases and review of the literature. Pediatr Pathol 1983;1:245–67.CrossRefGoogle ScholarPubMed
Zhou, X D, Tang, Z Y, Yang, B H. Experience of 1000 patients who underwent hepatectomy for small hepatocellular carcinoma. Cancer 2001;91:1479–86.3.0.CO;2-0>CrossRefGoogle ScholarPubMed
Shimada, M, Yonemura, Y, Ijichi, H. Living donor liver transplantation for hepatocellular carcinoma: a special reference to a preoperative des-gamma-carboxy prothrombin value. Transplant Proc 2005;37:1177–9.CrossRefGoogle ScholarPubMed
Capurro, M, Wanless, I R, Sherman, M. Glypican-3: a novel serum and histochemical marker for hepatocellular carcinoma. Gastroenterology 2003;125:89–97.CrossRefGoogle ScholarPubMed
Filmus, J, Capurro, M. Glypican-3 and alphafetoprotein as diagnostic tests for hepatocellular carcinoma. Mol Diagn 2004;8:207–12.CrossRefGoogle ScholarPubMed
Yamauchi, N, Watanabe, A, Hishinuma, M. The glypican 3 oncofetal protein is a promising diagnostic marker for hepatocellular carcinoma. Mod Pathol 2005;18:1591–8.CrossRefGoogle ScholarPubMed
Czauderna, P, Mackinlay, G, Perilongo, G. Hepatocellular carcinoma in children: results of the first prospective study of the International Society of Pediatric Oncology group. J Clin Oncol 2002;20:2798–804.CrossRefGoogle ScholarPubMed
Katzenstein, H M, London, W B, Douglass, E C. Treatment of unresectable and metastatic hepatoblastoma: a pediatric oncology group phase II study. J Clin Oncol 2002;20:3438–44.CrossRefGoogle ScholarPubMed
Aronson, D C, Schnater, J M, Staalman, C R. Predictive value of the pretreatment extent of disease system in hepatoblastoma: results from the International Society of Pediatric Oncology Liver Tumor Study Group SIOPEL-1 study. J Clin Oncol 2005;23:1245–52.CrossRefGoogle Scholar
Wu, J T, Book, L, Sudar, K. Serum alpha fetoprotein (AFP) levels in normal infants. Pediatr Res 1981;15:50–2.CrossRefGoogle ScholarPubMed
Reynolds, M. Conversion of unresectable to resectable hepatoblastoma and long-term follow-up study. World J Surg 1995;19:814–16.CrossRefGoogle ScholarPubMed
Ortega, J A, Krailo, M D, Haas, J E. Effective treatment of unresectable or metastatic hepatoblastoma with cisplatin and continuous infusion doxorubicin chemotherapy: a report from the Childrens Cancer Study Group. J Clin Oncol 1991;9:2167–76.CrossRefGoogle ScholarPubMed
Zimmermann, A. Hepatoblastoma with cholangioblastic features (“cholangioblastic hepatoblastoma”) and other liver tumors with bimodal differentiation in young patients. Med Pediatr Oncol 39:487–91.CrossRef
Ruck, P, Xiao, J C, Kaiserling, E. Small epithelial cells and the histogenesis of hepatoblastoma. Electron microscopic, immunoelectron microscopic, and immunohistochemical findings. Am J Pathol 1996;148:321–9.Google ScholarPubMed
Badve, S, Logdberg, L, Lal, A. Small cells in hepatoblastoma lack “oval” cell phenotype. Mod Pathol 2003;16:930–6.CrossRefGoogle ScholarPubMed
Fiegel, H C, Gluer, S, Roth, B. Stem-like cells in human hepatoblastoma. J Histochem Cytochem 2004;52:1495–501.CrossRefGoogle ScholarPubMed
Heifetz, S A, French, M, Correa, M, Grosfeld, J L. Hepatoblastoma: the Indiana experience with preoperative chemotherapy for inoperable tumors; clinicopathological considerations. Pediatr Pathol Lab Med 1997;17:857–74.CrossRefGoogle ScholarPubMed
Manivel, C, Wick, M R, Abenoza, P, Dehner, L P. Teratoid hepatoblastoma. The nosologic dilemma of solid embryonic neoplasms of childhood. Cancer 1986;57:2168–74.3.0.CO;2-M>CrossRefGoogle ScholarPubMed
Ruck, P, Harms, D, Kaiserling, E. Neuroendocrine differentiation in hepatoblastoma. An immunohistochemical investigation. Am J Surg Pathol 1990;14:847–55.CrossRefGoogle ScholarPubMed
Biegel, J A, Tan, L, Zhang, F. Alterations of the hSNF5/INI1 gene in central nervous system atypical teratoid/rhabdoid tumors and renal and extrarenal rhabdoid tumors. Clin Cancer Res 2002;8:3461–7.Google ScholarPubMed
Thorner, P, Squire, J, Plavsic, N. Expression of WT1 in pediatric small cell tumors: report of two cases with a possible mesothelial origin. Pediatr Dev Pathol 1999;2:33–41.CrossRefGoogle ScholarPubMed
Katzenstein, H M, Kletzel, M, Reynolds, M. Metastatic malignant rhabdoid tumor of the liver treated with tandem high-dose therapy and autologous peripheral blood stem cell rescue. Med Pediatr Oncol 2003;40:199–201.CrossRefGoogle ScholarPubMed
Scheimberg, I, Cullinane, C, Kelsey, A, Malone, M. Primary hepatic malignant tumor with rhabdoid features. A histological, immunocytochemical, and electron microscopic study of four cases and a review of the literature. Am J Surg Pathol 1996;20:1394–400.CrossRefGoogle Scholar
Donner, L R, Rao, A, Truss, L M, Dobin, S M. Translocation (8;13)(q24.2;q33) in a malignant rhabdoid tumor of the liver. Cancer Genet Cytogenet 2000;116:153–7.CrossRefGoogle ScholarPubMed
Mann, J R, Kasthuri, N, Raafat, F. Malignant hepatic tumours in children: incidence, clinical features and aetiology. Paediatr Perinat Epidemiol 1990;4:276–89.CrossRefGoogle ScholarPubMed
Gonzalez-Crussi, F, Upton, M P, Maurer, H S. Hepatoblastoma. Attempt at characterization of histologic subtypes. Am J Surg Pathol 1982;6:599–612.CrossRefGoogle ScholarPubMed
Daller, J A, Bueno, J, Gutierrez, J. Hepatic hemangioendothelioma: clinical experience and management strategy. J Pediatr Surg 34:98–105; discussion 105–6.CrossRef
Selby, D M, Stocker, J T, Waclawiw, M A. Infantile hemangioendothelioma of the liver. Hepatology 1994;20:39–45.Google ScholarPubMed
Mo, J Q, Dimashkieh, H H, Bove, K E. GLUT1 endothelial reactivity distinguishes hepatic infantile hemangioma from congenital hepatic vascular malformation with associated capillary proliferation. Hum Pathol 2004;35:200–9.CrossRefGoogle ScholarPubMed
Adler, B, Naheedy, J, Yeager, N. Multifocal epithelioid hemangioendothelioma in a 16-year-old boy. Pediatr Radiol 35:1014–18.CrossRef
Radin, D R, Craig, J R, CollettiPM, et al PM, et al. Hepatic epithelioid hemangioendothelioma. Radiology 1988;169:145–8.CrossRefGoogle ScholarPubMed
Selby, D M, Stocker, J T, Ishak, K G. Angiosarcoma of the liver in childhood: a clinicopathologic and follow-up study of 10 cases. Pediatr Pathol 1992;12:485–98.CrossRefGoogle ScholarPubMed
Awan, S, Davenport, M, Portmann, B, Howard, E R. Angiosarcoma of the liver in children. J Pediatr Surg 1996;31:1729–32.CrossRefGoogle ScholarPubMed
Chadarevian, J P, Pawel, B R, Faerber, E N, Weintraub, W H. Undifferentiated (embryonal) sarcoma arising in conjunction with mesenchymal hamartoma of the liver. Mod Pathol 1994;7:490–3.Google ScholarPubMed
Walker, N I, Horn, M J, Strong, R W. Undifferentiated (embryonal) sarcoma of the liver. Pathologic findings and long-term survival after complete surgical resection. Cancer 1992;69:52–9.3.0.CO;2-L>CrossRefGoogle ScholarPubMed
Lauwers, G Y, Grant, L D, Donnelly, W H. Hepatic undifferentiated (embryonal) sarcoma arising in a mesenchymal hamartoma. Am J Surg Pathol 1997;21:1248–54.CrossRefGoogle Scholar
Dalle, I, Sciot, R, Vos, R. Malignant angiomyolipoma of the liver: a hitherto unreported variant. Histopathology 2000;36:443–50.CrossRefGoogle ScholarPubMed
McKinney, C A, Geiger, J D, Castle, V P. Aggressive hepatic angiomyolipoma in a child. Pediatr Hematol Oncol 2005;22:17–24.CrossRefGoogle Scholar
Tomlinson, G E, Douglass, E C, Pollock, B H. Cytogenetic evaluation of a large series of hepatoblastomas: numerical abnormalities with recurring aberrations involving 1q12-q21. Genes Chromosomes Cancer 2005;44:177–84.CrossRefGoogle ScholarPubMed
Weber, R G, Pietsch, T, Schweinitz, D, Lichter, P. Characterization of genomic alterations in hepatoblastomas. A role for gains on chromosomes 8q and 20 as predictors of poor outcome. Am J Pathol 2000;157:571–8.CrossRefGoogle ScholarPubMed
Mullarkey, M, Breen, C J, McDermott, M. Genetic abnormalities in a pre and post-chemotherapy hepatoblastoma. Cytogenet Cell Genet 2001;95:9–11.CrossRefGoogle Scholar
Kumon, K, Kobayashi, H, Namiki, T. Frequent increase of DNA copy number in the 2q24 chromosomal region and its association with a poor clinical outcome in hepatoblastoma: cytogenetic and comparative genomic hybridization analysis. Jpn J Cancer Res 2001;92:854–62.CrossRefGoogle ScholarPubMed
Terracciano, L M, Bernasconi, B, Ruck, P. Comparative genomic hybridization analysis of hepatoblastoma reveals high frequency of X-chromosome gains and similarities between epithelial and stromal components. Hum Pathol 2003;34:864–71.CrossRefGoogle ScholarPubMed
Sainati, L, Leszl, A, Stella, M. Cytogenetic analysis of hepatoblastoma: hypothesis of cytogenetic evolution in such tumors and results of a multicentric study. Cancer Genet Cytogenet 104:39–44.CrossRef
Ma, S K, Cheung, A N, ChoyC, et al C, et al. Cytogenetic characterization of childhood hepatoblastoma. Cancer Genet Cytogenet 2000;119:32–6.CrossRefGoogle ScholarPubMed
Schneider, N R, Cooley, L D, Finegold, M J. The first recurring chromosome translocation in hepatoblastoma: der(4)t(1;4)(q12;q34). Genes Chromosomes Cancer 1997;19:291–4.3.0.CO;2-J>CrossRefGoogle Scholar
Parada, L A, Limon, J, Iliszko, M. Cytogenetics of hepatoblastoma: further characterization of 1q rearrangements by fluorescence in situ hybridization: an international collaborative study. Med Pediatr Oncol 2000;34:165–70.3.0.CO;2-T>CrossRefGoogle Scholar
Blanquet, V, Garreau, F, Chenivesse, X. Regional mapping to 4q32.1 by in situ hybridization of a DNA domain rearranged in human liver cancer. Hum Genet 1988;80:274–6.CrossRefGoogle ScholarPubMed
Terada, Y, Imoto, I, Nagai, H. An 8-cM interstitial deletion on 4q21-q22 in DNA from an infant with hepatoblastoma overlaps with a commonly deleted region in adult liver cancers. Am J Med Genet 2001;103:176–80.CrossRefGoogle Scholar
Pasquinelli, C, Garreau, F, Bougueleret, L. Rearrangement of a common cellular DNA domain on chromosome 4 in human primary liver tumors. J Virol 1988;62:629–32.Google ScholarPubMed
Chou, Y H, Chung, K C, Jeng, L B. Frequent allelic loss on chromosomes 4q and 16q associated with human hepatocellular carcinoma in Taiwan. Cancer Lett 1998;123:1–6.CrossRefGoogle ScholarPubMed
Zatkova, A, Rouillard, J M, Hartmann, W. Amplification and overexpression of the IGF2 regulator PLAG1 in hepatoblastoma. Genes Chromosomes Cancer 2004;39:126–37.CrossRefGoogle ScholarPubMed
Fletcher, J A, Kozakewich, H P, Pavelka, K. Consistent cytogenetic aberrations in hepatoblastoma: a common pathway of genetic alterations in embryonal liver and skeletal muscle malignancies?Genes Chromosomes Cancer 1991;3:37–43.CrossRefGoogle ScholarPubMed
Steenman, M, Westerveld, A, Mannens, M. Genetics of Beckwith–Wiedemann syndrome-associated tumors: common genetic pathways. Genes Chromosomes Cancer 2000;28:1–13.3.0.CO;2-#>CrossRefGoogle ScholarPubMed
Hatada, I, Ohashi, H, Fukushima, Y. An imprinted gene p57KIP2 is mutated in Beckwith-Wiedemann syndrome. Nat Genet 1996;14:171–3.CrossRefGoogle ScholarPubMed
Hartmann, W, Waha, A, Koch, A. p57(KIP2) is not mutated in hepatoblastoma but shows increased transcriptional activity in a comparative analysis of the three imprinted genes p57(KIP2), IGF2:and H19. Am J Pathol 2000;157:1393–403.CrossRefGoogle Scholar
Ross, J A, Radloff, G A, Davies, S M. H19 and IGF-2 allele-specific expression in hepatoblastoma. Br J Cancer 2000;82:753–6.CrossRefGoogle ScholarPubMed
Albrecht, S, Schweinitz, D, Waha, A. Loss of maternal alleles on chromosome arm 11p in hepatoblastoma. Cancer Res 1994;54:5041–4.Google ScholarPubMed
Rainier, S, Dobry, C J, Feinberg, A P. Loss of imprinting in hepatoblastoma. Cancer Res 1995;55:1836–8.Google ScholarPubMed
Eriksson, T, Frisk, T, Gray, S G. Methylation changes in the human IGF2 p3 promoter parallel IGF2 expression in the primary tumor, established cell line, and xenograft of a human hepatoblastoma. Exp Cell Res 2001;270:88–95.CrossRefGoogle ScholarPubMed
Albrecht, S, Hartmann, W, Houshdaran, F. Allelic loss but absence of mutations in the polyspecific transporter gene BWR1A on 11p15.5 in hepatoblastoma. Int J Cancer 2004;111:627–32.CrossRefGoogle ScholarPubMed
Toretsky, J A, Zitomersky, N L, Eskenazi, A E. Glypican-3 expression in Wilms tumor and hepatoblastoma. J Pediatr Hematol Oncol 2001;23:496–9.CrossRefGoogle ScholarPubMed
Horn, H, Tally, M, Hall, K. Expression levels of insulin-like growth factor binding proteins and insulin receptor isoforms in hepatoblastomas. Cancer Lett 2001;162:253–60.CrossRefGoogle Scholar
Koch, A, Denkhaus, D, Albrecht, S. Childhood hepatoblastomas frequently carry a mutated degradation targeting box of the beta-catenin gene. Cancer Res 1999;59:269–73.Google ScholarPubMed
Wei, Y, Fabre, M, Branchereau, S. Activation of beta-catenin in epithelial and mesenchymal hepatoblastomas. Oncogene 2000;19:498–504.CrossRefGoogle ScholarPubMed
López-Terrada, D G, Pulliam, J F. Analysis of beta-catenin status and Wnt pathway in different histologic subtypes of hepatoblastoma. Mod Pathol 2005;302.Google Scholar
Fukuzawa, R, Hata, J, HayashiY, et al Y, et al. Beckwith–Wiedemann syndrome-associated hepatoblastoma: wnt signal activation occurs later in tumorigenesis in patients with 11p15.5 uniparental disomy. Pediatr Dev Pathol 2003;6:299–306.CrossRefGoogle ScholarPubMed
Taniguchi, K, Robert,, L R, Aderca, I N. Mutational spectrum of beta-catenin, AXIN1:and AXIN2 in hepatocellular carcinomas and hepatoblastomas. Oncogene 2002;21:4863–71.CrossRefGoogle ScholarPubMed
Wirths, O, Waha, A, Weggen, S. Overexpression of human Dickkopf-1:an antagonist of wingless/WNT signaling, in human hepatoblastomas and Wilms' tumors. Lab Invest 2003;83:429–34.CrossRefGoogle ScholarPubMed
Koch, A, Waha, A, Hartmann, W. Elevated expression of Wnt antagonists is a common event in hepatoblastomas. Clin Cancer Res 11:4295–304.CrossRef
Takayasu, H, Horie, H, HiyamaE, et al E, et al. Frequent deletions and mutations of the beta-catenin gene are associated with overexpression of cyclin D1 and fibronectin and poorly differentiated histology in childhood hepatoblastoma. Clin Cancer Res 2001;7:901–8.Google Scholar
Anna, C H, Iida, M, Sills, R C, Devereux, T R. Expression of potential beta-catenin targets, cyclin D1:c-Jun, c-Myc, E-cadherin, and EGFR in chemically induced hepatocellular neoplasms from B6C3F1 mice. Toxicol Appl Pharmacol, 2003;190:135–45.CrossRefGoogle ScholarPubMed
Kim, H, Ham, E K, Kim, Y I. Overexpression of cyclin D1 and cdk4 in tumorigenesis of sporadic hepatoblastomas. Cancer Lett 1998;131:177–83.CrossRefGoogle ScholarPubMed
Pakakasama, S, Chen, T T, Frawley, W. CCND1 polymorphism and age of onset of hepatoblastoma. Oncogene 2004;23:4789–92.CrossRefGoogle ScholarPubMed
Shim, Y H, Park, H J, Choi, M S. Hypermethylation of the p16 gene and lack of p16 expression in hepatoblastoma. Mod Pathol 2003;16:430–6.CrossRefGoogle ScholarPubMed
Brotto, M, Finegold, M J. Distinct patterns of p27/KIP 1 gene expression in hepatoblastoma and prognostic implications with correlation before and after chemotherapy. Hum Pathol 2002;33:198–205.CrossRefGoogle ScholarPubMed
Kiss, A, Szepesi, A, Lotz, G. Expression of transforming growth factor-alpha in hepatoblastoma. Cancer 1998;83:690–7.3.0.CO;2-O>CrossRefGoogle ScholarPubMed
Lee, S H, Shin, M S, Lee, J Y. In vivo expression of soluble Fas and FAP-1: possible mechanisms of Fas resistance in human hepatoblastomas. J Pathol 1999;188:207–12.3.0.CO;2-8>CrossRefGoogle ScholarPubMed
Hiyama, E, Yamaoka, H, Matsunaga, T. High expression of telomerase is an independent prognostic indicator of poor outcome in hepatoblastoma. Br J Cancer 2004;91:972–9.CrossRefGoogle ScholarPubMed
Buendia, M A. Genetics of hepatocellular carcinoma. Semin Cancer Biol 2000;10:185–200.CrossRefGoogle ScholarPubMed
Suriawinata, A, Xu, R. An update on the molecular genetics of hepatocellular carcinoma. Semin Liver Dis 2004;24:77–88.Google ScholarPubMed
Wong, N, Lai, P, Pang, E. A comprehensive karyotypic study on human hepatocellular carcinoma by spectral karyotyping. Hepatology 2000;32:1060–8.CrossRefGoogle ScholarPubMed
Buendia, M A. Genetic alterations in hepatoblastoma and hepatocellular carcinoma: common and distinctive aspects. Med Pediatr Oncol 2002;39:530–5.CrossRefGoogle ScholarPubMed
Iliszko, M, Czauderna, P, Babinska, M. Cytogenetic findings in an embryonal sarcoma of the liver. Cancer Genet Cytogenet 1998;102:142–4.CrossRefGoogle Scholar
O'Sullivan, M J, Swanson, P E, Knoll, J. Undifferentiated embryonal sarcoma with unusual features arising within mesenchymal hamartoma of the liver: report of a case and review of the literature. Pediatr Dev Pathol 2001;4:482–9.CrossRefGoogle ScholarPubMed
Speleman, F, Telder, V, Potter, K R. Cytogenetic analysis of a mesenchymal hamartoma of the liver. Cancer Genet Cytogenet 1989;40:29–32.CrossRefGoogle ScholarPubMed
Mascarello, J T, Krous, H F. Second report of a translocation involving 19q13.4 in a mesenchymal hamartoma of the liver. Cancer Genet Cytogenet 1992;58:141–2.CrossRefGoogle Scholar
Rakheja, D, Margraf, L R, Tomlinson, G E, Schneider, N R. Hepatic mesenchymal hamartoma with translocation involving chromosome band 19q13.4: a recurrent abnormality. Cancer Genet Cytogenet 2004;153:60–3.CrossRefGoogle ScholarPubMed
Bove, K E, Blough, R I, Soukup, S. Third report of t(19q)(13.4) in mesenchymal hamartoma of liver with comments on link to embryonal sarcoma. Pediatr Dev Pathol 1998;1:438–42.Google Scholar
Ito, H, Yamasaki, T, Okamoto, O, Tahara, E. Infantile hemangioendothelioma of the liver in patient with interstitial deletion of chromosome 6q: report of an autopsy case. Am J Med Genet 1989;34:325–9.CrossRefGoogle ScholarPubMed
Tannapfel, A, Weihrauch, M, Benicke, M. p16INK4A-alterations in primary angiosarcoma of the liver. J Hepatol 2001;35:62–7.CrossRefGoogle ScholarPubMed
Soini, Y, Welsh, J A, Ishak, K G, Bennett, W P. p53 mutations in primary hepatic angiosarcomas not associated with vinyl chloride exposure. Carcinogenesis 1995;16:2879–81.CrossRefGoogle Scholar
Fuchs, J, Rydzynski, J, Schweinitz, D. Pretreatment prognostic factors and treatment results in children with hepatoblastoma: a report from the German Cooperative Pediatric Liver Tumor Study HB 94. Cancer 2002;95:172–82.CrossRefGoogle ScholarPubMed
Schweinitz, D, Hecker, H, Schmidt-von-Arndt, G, Harms, D. Prognostic factors and staging systems in childhood hepatoblastoma. Int J Cancer 1997;74:593–9.3.0.CO;2-P>CrossRefGoogle Scholar
Brown, J, Perilongo, G, Shafford, E. Pretreatment prognostic factors for children with hepatoblastoma – results from the International Society of Paediatric Oncology (SIOP) study SIOPEL 1. Eur J Cancer 2000;36:1418–25.CrossRefGoogle ScholarPubMed
Schweinitz, D, Byrd, D J, Hecker, H. Efficiency and toxicity of ifosfamide, cisplatin and doxorubicin in the treatment of childhood hepatoblastoma. Study Committee of the Cooperative Paediatric Liver Tumour Study HB89 of the German Society for Paediatric Oncology and Haematology. Eur J Cancer 1997;33:1243–9.CrossRefGoogle Scholar
Haas, J E, Feusner, J H, Finegold, M J. Small cell undifferentiated histology in hepatoblastoma may be unfavorable. Cancer 2001;92:3130–4.3.0.CO;2-#>CrossRefGoogle ScholarPubMed
Haas, J E, Muczynski, K A, Krailo, M. Histopathology and prognosis in childhood hepatoblastoma and hepatocarcinoma. Cancer 1989;64:1082–95.3.0.CO;2-G>CrossRefGoogle ScholarPubMed
Ortega, J A, Douglass, E C, Feusner, J H. Randomized comparison of cisplatin/vincristine/fluorouracil and cisplatin/continuous infusion doxorubicin for treatment of pediatric hepatoblastoma: a report from the Children's Cancer Group and the Pediatric Oncology Group. J Clin Oncol 2000;18:2665–75.CrossRefGoogle ScholarPubMed
Hata, Y, Ishizu, H, Ohmori, K. Flow cytometric analysis of the nuclear DNA content of hepatoblastoma. Cancer 1991;68:2566–70.3.0.CO;2-Z>CrossRefGoogle ScholarPubMed
Zerbini, M C, Sredni, S T, Grier, H. Primary malignant epithelial tumors of the liver in children: a study of DNA content and oncogene expression. Pediatr Dev Pathol 1998;1:270–80.CrossRefGoogle ScholarPubMed
Park, W S, Oh, R R, Park, J Y. Nuclear localization of beta-catenin is an important prognostic factor in hepatoblastoma. J Pathol 2001;193:483–90.3.0.CO;2-R>CrossRefGoogle ScholarPubMed
Yamaoka, H, Ohtsu, K, Sueda, T. Diagnostic and prognostic impact of beta-catenin alterations in pediatric liver tumors. Oncol Rep 2006;15:551–6.Google ScholarPubMed
Yamada, S, Ohira, M, Horie, H. Expression profiling and differential screening between hepatoblastomas and the corresponding normal livers: identification of high expression of the PLK1 oncogene as a poor-prognostic indicator of hepatoblastomas. Oncogene 2004;23:5901–11.CrossRefGoogle ScholarPubMed
King, D R, Ortega, J, Campbell, J. The surgical management of children with incompletely resected hepatic cancer is facilitated by intensive chemotherapy. J Pediatr Surg 1991;26:1074–80; discussion 1080–1.CrossRefGoogle ScholarPubMed
Schnater, J M, Aronson, D C, Plaschkes, J. Surgical view of the treatment of patients with hepatoblastoma: results from the first prospective trial of the International Society of Pediatric Oncology Liver Tumor Study Group. Cancer 2002;94:1111–20.CrossRefGoogle ScholarPubMed
Luks, F I, Yazbeck, S, Brandt, M L. Benign liver tumors in children: a 25-year experience. J Pediatr Surg 1991;26:1326–30.CrossRefGoogle ScholarPubMed
Ramanujam, T M, Ramesh, J C, Goh, D W. Malignant transformation of mesenchymal hamartoma of the liver: case report and review of the literature. J Pediatr Surg 1999;34:1684–6.CrossRefGoogle ScholarPubMed
Gangopadhyay, A N, Sharma, S P, Gopal, S C. Mesenchymal hamartoma of liver. Indian Pediatr 1995;32:1109–11.Google ScholarPubMed
Rosenberg, A S, Kirk, J, Morgan, M B. Rhabdomyomatous mesenchymal hamartoma: an unusual dermal entity with a report of two cases and a review of the literature. J Cutan Pathol 2002;29:238–43.CrossRefGoogle Scholar
Black, C T, Cangir, A, Choroszy, M, Andrassy, R J. Marked response to preoperative high-dose cis-platinum in children with unresectable hepatoblastoma. J Pediatr Surg 1991;26:1070–3.CrossRefGoogle ScholarPubMed
Finegold, M J. Chemotherapy for suspected hepatoblastoma without efforts at surgical resection is a bad practice. Med Pediatr Oncol 2002;39:484–6.CrossRefGoogle ScholarPubMed
Reynolds, M, Douglass, E C, Finegold, M. Chemotherapy can convert unresectable hepatoblastoma. J Pediatr Surg 1992;27:1080–3; discussion 1083–4.CrossRefGoogle ScholarPubMed
Passmore, S J, Noblett, H R, Wisheart, J D, Mott, M G. Prolonged survival following multiple thoracotomies for metastatic hepatoblastoma. Med Pediatr Oncol 1995;24:58–60.CrossRefGoogle ScholarPubMed
Vivarelli, M, Guglielmi, A, Ruzzenente, A. Surgical resection versus percutaneous radiofrequency ablation in the treatment of hepatocellular carcinoma on cirrhotic liver. Ann Surg 240:102–7.CrossRef
Kubo, S, Taukamoto, T, HirohashiK, et al K, et al. Appropriate surgical management of small hepatocellular carcinomas in patients infected with hepatitis C virus. World J Surg 2003;27:437–42.CrossRefGoogle ScholarPubMed
Suita, S, Tajiri, T, Takamatsu, H. Improved survival outcome for hepatoblastoma based on an optimal chemotherapeutic regimen–a report from the study group for pediatric solid malignant tumors in the Kyushu area. J Pediatr Surg 2004;39:195–8; discussion 195–8.CrossRefGoogle Scholar
Casanova, M, Massimino, M, Ferrari, A. Etoposide, cisplatin, epirubicin chemotherapy in the treatment of pediatric liver tumors. Pediatr Hematol Oncol 2005;22:189–98.CrossRefGoogle ScholarPubMed
Matsunaga, T, Sasaki, F, Ohira, M. Analysis of treatment outcome for children with recurrent or metastatic hepatoblastoma. Pediatr Surg Int 2003;19:142–6.Google ScholarPubMed
Katzenstein, H M, Krailo, M D, Malogolowkin, M H. Hepatocellular carcinoma in children and adolescents: results from the Pediatric Oncology Group and the Children's Cancer Group intergroup study. J Clin Oncol 2002;20:2789–97.CrossRefGoogle ScholarPubMed
Enjolras, O, Riche, M C, Merland, J J, Escande, J P. Management of alarming hemangiomas in infancy: a review of 25 cases. Pediatrics 1990;85:491–8.Google ScholarPubMed
Iyer, C P, Stanley, P, Mahoure, G H. Hepatic hemangiomas in infants and children: a review of 30 cases. Am Surg 1996;62:356–60.Google ScholarPubMed
Mulliken, J B, Boon, L M, Takahashi, K. Pharmacologic therapy for endangering hemangiomas. Curr Opin Dermatol 1995;2:109–13.Google Scholar
Barlow, C F, Priebe, C J, Mulliken, J B. Spastic diplegia as a complication of interferon alfa-2a treatment of hemangiomas of infancy. J Pediatr 1998;132:527–30.CrossRefGoogle ScholarPubMed
Koh, L K, Greenspan, F S, Yeo, P P. Interferon-alpha induced thyroid dysfunction: three clinical presentations and a review of the literature. Thyroid 1997;7:891–6.CrossRefGoogle Scholar
Jones, T H, Wadler, S, Hupart, K H. Endocrine-mediated mechanisms of fatigue during treatment with interferon-alpha. Semin Oncol 1998;25:54–63.Google ScholarPubMed
Gunawardena, S W, Trautwein, L M, Finegold, M J, Ogden, A K. Hepatic angiosarcoma in a child: successful therapy with surgery and adjuvant chemotherapy. Med Pediatr Oncol 1997;28:139–43.3.0.CO;2-L>CrossRefGoogle Scholar
Prokurat, A, Chrupek, M, Kosciesza, A. Hemangioma of the liver in children – conservative versus operative treatment. Surg Childh Intern 2000;3:202–7.Google Scholar
Bisogno, G, Pilz, T, Perilongo, G. Undifferentiated sarcoma of the liver in childhood: a curable disease. Cancer 2002;94:252–7.CrossRefGoogle ScholarPubMed
Kim, D Y, Kim, K H, Jung, S E. Undifferentiated (embryonal) sarcoma of the liver: combination treatment by surgery and chemotherapy. J Pediatr Surg 2002;37:1419–23.CrossRefGoogle ScholarPubMed
Spunt, S L, Lobe, T E, Pappo, A S. Aggressive surgery is unwarranted for biliary tract rhabdomyosarcoma. J Pediatr Surg 2000;35:309–16.CrossRefGoogle ScholarPubMed
Pritchard, J, Brown, J, Shafford, E. Cisplatin, doxorubicin, and delayed surgery for childhood hepatoblastoma: a successful approach – results of the first prospective study of the International Society of Pediatric Oncology. J Clin Oncol 2000;18:3819–28.CrossRefGoogle ScholarPubMed
Otte, J B, Pritchard, J, AronsonDC, et al DC, et al. Liver transplantation for hepatoblastoma: results from the International Society of Pediatric Oncology [SIOP] study SIOPEL-1 and review of the world experience. Pediatr Blood Cancer 2004;42:74–83.CrossRefGoogle ScholarPubMed
Tiao, G M, Bobey, N, Allen, S. The current management of hepatoblastoma: a combination of chemotherapy, conventional resection, and liver transplantation. J Pediatr 146:204–11.CrossRef
Reyes, J D, Carr, B, DvorchikI, et al I, et al. Liver transplantation and chemotherapy for hepatoblastoma and hepatocellular cancer in childhood and adolescence. J Pediatr 2000;136:795–804.CrossRefGoogle ScholarPubMed
Austin, M T, Leys, C M, Feurer, I D. Liver transplantation for childhood hepatic malignancy: a review of the United Network for Organ Sharing (UNOS) database. J Pediatr Surg 2006;41:182–6.CrossRefGoogle ScholarPubMed
Habrand, J L, Pritchard, J. Role of radiotherapy in hepatoblastoma and hepatocellular carcinoma in children and adolescents: results of a survey conducted by the SIOP Liver Tumour Study Group. Med Pediatr Oncol 1991;19:208.CrossRefGoogle ScholarPubMed
Guo, W J, Yu, E X, Liu, L M. Comparison between chemoembolization combined with radiotherapy and chemoembolization alone for large hepatocellular carcinoma. World J Gastroenterol 2003;9:1697–701.CrossRefGoogle ScholarPubMed
Cheng, J C, Wu, J KHuang, C M. Radiation-induced liver disease after three-dimensional conformal radiotherapy for patients with hepatocellular carcinoma: dosimetric analysis and implication. Int J Radiat Oncol Biol Phys 2002;54:156–62.CrossRefGoogle ScholarPubMed
Habrand, J L, Nehme, D, Kalifa, C. Is there a place for radiation therapy in the management of hepatoblastomas and hepatocellular carcinomas in children?Int J Radiat Oncol Biol Phys 1992;23:525–31.CrossRefGoogle Scholar
Park, H C, Seong, J, Han, K H. Dose-response relationship in local radiotherapy for hepatocellular carcinoma. Int J Radiat Oncol Biol Phys 2002;54:150–5.CrossRefGoogle ScholarPubMed
Dawson, L A, McGinn, C J, Lawrence, T S. Conformal chemoradiation for primary and metastatic liver malignancies. Semin Surg Oncol 2003;21:249–55.CrossRefGoogle ScholarPubMed
Oue, T, Fukuzawa, M, Kusafuka, T. Transcatheter arterial chemoembolization in the treatment of hepatoblastoma. J Pediatr Surg 1998;33:1771–5.CrossRefGoogle ScholarPubMed
Malogolowkin, M H, Stanley, P, Steele, D A, Ortega, J A. Feasibility and toxicity of chemoembolization for children with liver tumors. J Clin Oncol 2000;18:1279–84.CrossRefGoogle ScholarPubMed
Braybrooke, J P, Propper, D J, O'Byrne, K J. Induction of thymidine phosphorylase as a pharmacodynamic end-point in patients with advanced carcinoma treated with 5-fluorouracil, folinic acid and interferon alpha. Br J Cancer 2000;83:219–24.CrossRefGoogle ScholarPubMed
Marchetti, S, Chazal, M, Dubreuil, A. Impact of thymidine phosphorylase surexpression on fluoropyrimidine activity and on tumour angiogenesis. Br J Cancer 2001;85:439–45.CrossRefGoogle ScholarPubMed
Leung, T W, Tang, A M, Zee, B. Factors predicting response and survival in 149 patients with unresectable hepatocellular carcinoma treated by combination cisplatin, interferon-alpha, doxorubicin and 5-fluorouracil chemotherapy. Cancer 2002;94:421–7.CrossRefGoogle ScholarPubMed
Patt, Y Z, Hassan, M M, Lozano, R D. Phase II trial of systemic continuous fluorouracil and subcutaneous recombinant interferon Alfa-2b for treatment of hepatocellular carcinoma. J Clin Oncol 2003;21:421–7.CrossRefGoogle ScholarPubMed
Galvao, F H, Bakonyi-Neto, A, Machado, M A. Interferon alpha-2B and liver resection to treat multifocal hepatic epithelioid hemangioendothelioma: a relevant approach to avoid liver transplantation. Transplant Proc 2005;37:4354–8.CrossRefGoogle ScholarPubMed
Mizejewski, G J. Biological role of alpha-fetoprotein in cancer: prospects for anticancer therapy. Expert Rev Anticancer Ther 2002;2:709–35.CrossRefGoogle ScholarPubMed
Kairemo, K J, Lindahl, H, Merenmies, J. Anti-alpha-fetoprotein imaging is useful for staging hepatoblastoma. Transplantation 2002;73:1151–4.CrossRefGoogle ScholarPubMed
Raymond, E, Faivre, S, Chaney, S. Cellular and molecular pharmacology of oxaliplatin. Mol Cancer Ther 2002;1:227–35.Google ScholarPubMed
Katzenstein, H, Chang, K C, Krailo, M. Presented at the American Society of Clinical Oncology, New Orleans, Louisiana, 2004.
Warmann, S, Hunger, M, TeichmannB, et al B, et al. The role of the MDR1 gene in the development of multidrug resistance in human hepatoblastoma: clinical course and in vivo model. Cancer 2002;95:1795–801.CrossRefGoogle ScholarPubMed
Schnater, J M, Kohler, S E, Lamers, W H. Where do we stand with hepatoblastoma? A review. Cancer 2003;98:668–78.CrossRefGoogle ScholarPubMed
Murono, S, Yoshizaki, T, Sato, H. Aspirin inhibits tumor cell invasiveness induced by Epstein-Barr virus latent membrane protein 1 through suppression of matrix metalloproteinase-9 expression. Cancer Res 2000;60:2555–61.Google ScholarPubMed
Cianchi, F, Cortesini, C, Bechi, P. Up-regulation of cyclooxygenase 2 gene expression correlates with tumor angiogenesis in human colorectal cancer. Gastroenterology 2001;121:1339–47.CrossRefGoogle ScholarPubMed
Ishikawa, H, Nakao, K, Matsumoto, K. Antiangiogenic gene therapy for hepatocellular carcinoma using angiostatin gene. Hepatology 2003;37:696–704.CrossRefGoogle ScholarPubMed
Koga, H. Hepatocellular carcinoma: is there a potential for chemoprevention using cyclooxygenase-2 inhibitors?Cancer 2003;98:661–7.CrossRefGoogle Scholar
Mascarenhas, R C, Sanghvi, A N, Friedlander, L. Thalidomide inhibits the growth and progression of hepatic epithelioid hemangioendothelioma. Oncology 2004;67:471–5.CrossRefGoogle ScholarPubMed

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  • Tumors of the Liver
    • By Dolores López-Terrada, M.D., Ph.D., Assistant Professor, Department of Pathology, Baylor College of Medicine, Houston, Texas; Pathologist, Department of Pathology, Texas Children's Hospital, Houston, Texas, Milton J. Finegold, M.D., Professor, Department of Pathology and Pediatrics, Baylor College of Medicine, Houston, Texas; Head of Pathology Department, Texas Children's Hospital, Houston, Texas
  • Edited by Frederick J. Suchy, Mount Sinai School of Medicine, New York, Ronald J. Sokol, University of Colorado, Denver, William F. Balistreri, University of Cincinnati
  • Book: Liver Disease in Children
  • Online publication: 18 December 2009
  • Chapter DOI: https://doi.org/10.1017/CBO9780511547409.042
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  • Tumors of the Liver
    • By Dolores López-Terrada, M.D., Ph.D., Assistant Professor, Department of Pathology, Baylor College of Medicine, Houston, Texas; Pathologist, Department of Pathology, Texas Children's Hospital, Houston, Texas, Milton J. Finegold, M.D., Professor, Department of Pathology and Pediatrics, Baylor College of Medicine, Houston, Texas; Head of Pathology Department, Texas Children's Hospital, Houston, Texas
  • Edited by Frederick J. Suchy, Mount Sinai School of Medicine, New York, Ronald J. Sokol, University of Colorado, Denver, William F. Balistreri, University of Cincinnati
  • Book: Liver Disease in Children
  • Online publication: 18 December 2009
  • Chapter DOI: https://doi.org/10.1017/CBO9780511547409.042
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  • Tumors of the Liver
    • By Dolores López-Terrada, M.D., Ph.D., Assistant Professor, Department of Pathology, Baylor College of Medicine, Houston, Texas; Pathologist, Department of Pathology, Texas Children's Hospital, Houston, Texas, Milton J. Finegold, M.D., Professor, Department of Pathology and Pediatrics, Baylor College of Medicine, Houston, Texas; Head of Pathology Department, Texas Children's Hospital, Houston, Texas
  • Edited by Frederick J. Suchy, Mount Sinai School of Medicine, New York, Ronald J. Sokol, University of Colorado, Denver, William F. Balistreri, University of Cincinnati
  • Book: Liver Disease in Children
  • Online publication: 18 December 2009
  • Chapter DOI: https://doi.org/10.1017/CBO9780511547409.042
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