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  • Print publication year: 2015
  • Online publication date: September 2015

24 - Chimpanzee self-medication: a historical perspective of the key findings

from Part V - Life history and health
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Mahale Chimpanzees
  • Online ISBN: 9781107280533
  • Book DOI: https://doi.org/10.1017/CBO9781107280533
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Abbiw, D. K. (1990). Useful Plants of Ghana. Kew, UK: Intermediate Technology Publications and Royal Botanic Gardens.
Brack, M. (1987). Agents Transmissible from Simians to Man. Berlin: Springer-Verlag.
Constable, C. P. and Towers, G. H. N. (1989). The complex nature of the mechanism of toxicity and antibiotic dithiacylohexadiene polylines (thiarubrines) from the Asteraceae. Planta Medica, 55, 35–7.
Cousins, D. and Huffman, M. A. (2002). Medicinal properties in the diet of gorillas – An ethnopharmacological evaluation. African Studies Monographs, 23, 6589.
Engel, C. (2002). Wild Health. Boston: Houghton Mifflin.
Fruth, B., Ikombe, N. B., Matshimba, G. K., et al. (2014). New evidence for self-medication in bonobos: Maniophyton fulvum leaf- and stemstrip-swallowing from LuiKotale, Salonga National Park, DR Congo. American Journal of Primatology, 76, 146–58.
Githen, T. S. (1949). Drug Plants of Africa. Pittsburg, PN: University of Pennsylvania Press.
Goodall, J. (2013). Seeds of Hope: Wisdom and Wonder from the World of Plants. New York: Grand Central Publishing.
Howe, H. F. and Westley, L. C. (1988). Ecological Relationships of Plants and Animals. New York: Oxford University Press.
Huffman, M. A. (1993). [An investigation of the use of medicinal plants by wild chimpanzees. Current status and future prospects.] Primate Research, 9, 179–87. In Japanese with English summary.
Huffman, M. A. (1994). The CHIMPP Group: A multi-disciplinary investigation into the use of medicinal plants by chimpanzees. Pan Africa News, 1(1), 35.
Huffman, M. A. (1997). Current evidence for self-medication in primates: A multidisciplinary perspective. Yearbook of Physical Anthropology, 40, 171200.
Huffman, M. A. (2001). Self-medicative behavior in the African great apes: An evolutionary perspective into the origins of human traditional medicine. BioScience, 51, 651–61.
Huffman, M. A. (2002). Animal origins of herbal medicine. In From the Sources of Knowledge to the Medicines of the Future, ed. Fleurentin, J., Pelt, J-M., and Mazars, G.. Paris: IRD Editions, pp. 3142.
Huffman, M. A. (2007). Primate self-medication. In Primates in Perspective, ed. Campbell, C., Fuentes, A., MacKinnon, K., Panger, M., and Bearder, S.. Oxford: University of Oxford Press, pp. 677–90.
Huffman, M. A. (2010). Self-medication: passive prevention and active treatment. In Encyclopedia of Animal Behavior, ed. Breed, M. D. and Moore, J.. Oxford: Academic Press, pp. 125–31.
Huffman, M. A. and Caton, J. M. (2001). Self-induced increase of gut motility and the control of parasitic infections in wild chimpanzees. International Journal of Primatology, 22, 329–46.
Huffman, M. A and Hirata, S. (2004). An experimental study of leaf swallowing in captive chimpanzees: insights into the origin of a self-medicative behavior and the role of social learning. Primates, 45, 113–18.
Huffman, M. A. and MacIntosh, A. J. J. (2012). Plant food diet of the Arashiyama-Kyoto Japanese macaques and its potential medicinal value. In The Monkeys of Stormy Mountain: 60 Years of Primatological Research on the Japanese Macaques of Arashiyama, ed. Leca, J-B, Huffman, M. A., and Vasey, P. L.. Cambridge: Cambridge University Press, pp. 356431.
Huffman, M. A. and Seifu, M. (1989). Observations on the illness and consumption of a possibly medicinal plant Vernonia amygdalina (Del.), by a wild chimpanzee in the Mahale Mountains National Park, Tanzania. Primates, 30, 5163.
Huffman, M. A. and Wrangham, R. W. (1994). The diversity of medicinal plant use by chimpanzees in the wild. In Chimpanzee Cultures, ed. Wrangham, R. W., McGrew, W. C., deWaal, F. B. and Heltne, P. G.. Cambridge MA: Harvard University Press, pp. 129–48.
Huffman, M. A., Nishida, T., and Uehara, S. (1990). Intestinal parasites and medicinal plant use in wild chimpanzees: possible behavioral adaptation for the control of parasites. Mahale Mountains Chimpanzees Research Project. Ecological Report, 72.
Huffman, M. A., Gotoh, S., Izutsu, D., Koshimizu, K., and Kalunde, M. S. (1993). Further observations on the use of Vernonia amygdalina by a wild chimpanzee, its possible effect on parasite load, and its phytochemistry. African Study Monographs, 14, 227–40.
Huffman, M. A., Koshimizu, K., and Ohigashi, H. (1996a). Ethnobotany and zoopharmacognosy of Vernonia amygdalina, a medicinal plant used by humans and chimpanzees. In Compositae: Biology & Utilization Vol. 2, ed. Caligari, P. D. S. and Hind, D. J. N.. Kew: The Royal Botanical Gardens, pp. 351–60.
Huffman, M. A., Page, J. E., Sukhdeo, M. V. K., et al. (1996b). Leaf-swallowing by chimpanzees, a behavioral adaptation for the control of strongyle nematode infections. International Journal of Primatology, 72, 475503.
Huffman, M. A., Gotoh, S., Turner, L. A., Hamai, M., and Yoshida, K. (1997). Seasonal trends in intestinal nematode infection and medicinal plant use among chimpanzees in the Mahale Mountains, Tanzania. Primates, 38, 111–25.
Huffman, M. A., Pebsworth, P., Bakuneeta, C., Gotoh, S., and Bardi, M. (2009). Macro-habitat comparison of host–parasite ecology in two populations of chimpanzees in the Budongo Forest, Uganda and the Mahale Mountains, Tanzania. In Primate Parasite Ecology: The Dynamics of Host-parasite Relationships, ed. Huffman, M. A. and Chapman, C.. Cambridge: Cambridge University Press, pp. 311–30.
Huffman, M. A., Spiezio, C., Sgaravatti, A., and Leca, J-B. (2010). Option biased learning involved in the acquisition and transmission of leaf swallowing behavior in chimpanzees (Pan troglodytes)? Animal Cognition, 13, 871–80.
Izevbigie, E. B. (2005). Phytochemotherapy for cancer. US Patent application 756241. January 13, 2004
Janzen, D. H. (1978). Complications in interpreting the chemical defenses of trees against tropical arboreal plant-eating vertebrates. In The Ecology of Arboreal Folivores, ed. Montgomery, G. G.. Washington DC: Smithsonian Institute Press, pp. 7384.
Jisaka, M., Kawanaka, M., Sugiyama, H., et al. (1992a). Antischistosomal activities of sesquiterpene lactones and steroid glucosides from V. amygdalina, possibly used by wild chimpanzees against parasite-related disease. Bioscience, Biotechnology and Biochemistry, 56, 845–6.
Jisaka, M., Ohigashi, H., Takagaki, T., et al. (1992b). Bitter steroid glucosides, Vernoniosides A1, A2 and A3 and related B1 from a possible medicinal plant Vernonia amygdalina, used by wild chimpanzees. Tetrahedron, 48, 625–32.
Jisaka, M., Ohigashi, H., Takegawa, K., Huffman, M. A., and Koshimizu, K. (1993a). Antitumoral and antimicrobial activities of bitter sesquiterpene lactones of Vernonia amygdalina, a possible medicinal plant used by wild chimpanzee. Bioscience, Biotechnology and Biochemistry, 57, 833–4.
Jisaka, M., Ohigashi, H., Takegawa, K., et al. (1993b). Steroid glucosides from Vernonia amygdalina, a possible chimpanzee medicinal plant. Phytochemistry, 34, 409–13.
Johns, T. (1990). With Bitter Herbs They Shall Eat It. Tucson, AZ: The University of Arizona Press.
Kawabata, M. and Nishida, T. (1991). A preliminary note on the intestinal parasites of wild chimpanzees of the Mahale Mountains, Tanzania. Primates, 32, 275–8.
Kokwaro, J. (1976). Medicinal Plants of East Africa. Nairobi: East African Literature Bureau.
Koshimizu, K., Ohigashi, H., Huffman, M. A., Nishida, T., and Takasaki, H. (1993). Physiological activities and the active constituents of potentially medicinal plants used by wild chimpanzees of the Mahale Mountains, Tanzania. International Journal of Primatology, 14(2), 345–56.
Krief, S., Hladik, C. M., and Haxaire, C. (2005). Ethnomedicinal and bioactive properties of plants ingested by wild chimpanzees in Uganda. Journal of Ethnopharmacology, 101, 115.
Krief, S., Huffman, M. A., Sevenet, T., et al. (2006). Bioactive properties of plant species ingested by chimpanzees (Pan troglodytes schweinfurthii) in the Kibale National Park, Uganda. American Journal of Primatology, 68, 5171.
Kupchan, S. M., Hemingway, R. J., Karim, A., and Werner, D. (1969). Tumor Inhibitors XLVII. Vernodalin and vernomygdin, two new cytotoxic sesquiterpene lactones from Vernonia amygdalina Del. Journal of Organic Chemistry, 34, 3908–11.
Looi, C. C., Arya, A., Chea, F. K., et al. (2013). Induction of apoptosis in human breast cancer cells via caspase pathway by vernodalin isolated from Centratherum anthelminticum (L.) seeds. PLoS ONE, 8, e56643.
MacIntosh, A. J. J. and Huffman, M. A. (2010). Towards understanding the role of diet in host-parasite interactions: the case for Japanese macaques. In The Japanese Macaques, ed. Nakagawa, N., Nakamichi, M., and Sugiura, H.. Tokyo: Springer, pp. 323–44.
Masi, S., Gustafsson, E., Saint Jalme, M., et al. (2012). Unusual feeding behavior in wild great apes, a window to understand origins of self-medication in humans: Role of sociality and physiology on learning process. Physiology & Behavior, 105, 337–49.
McLennan, M. R. and Huffman, M. A. (2012). High frequency of leaf swallowing and its relationship to parasite expulsion in “village” chimpanzees at Bulindi, Uganda. American Journal of Primatology, 74, 642–50.
Messer, E. J. and Wrangham, R. W. (1996). In vitro testing of the biological activity of Rubia cordifolia leaves on primate Strongyloides species. Primates, 37, 105–8.
Neuwinger, H. D. (1996). African Ethnobotany: Chemistry, Pharmacology, Toxicology. London: Chapman & Hill.
Newton, P. N. and Nishida, T. (1990). Possible buccal administration of herbal drugs by wild chimpanzees, Pan troglodytes. Animal Behaviour, 39, 798801.
Nishida, T. (2012). Chimpanzees of the Lakeshore: Natural History and Culture at Mahale. Cambridge: Cambridge University Press.
Ohigashi, H. (1995). Plants used medicinally by primates in the wild and their physiologically active constituents. Report to the Ministry of Science, Education and Culture for 1994 Grant-in-Aid for Scientific Research (No. 06303012).
Ohigashi, H., Jisaka, M., Takagaki, T., et al. (1991). Bitter principle and a related steroid glucoside from Vernonia amygdalina, a possible medicinal plant for wild chimpanzees. Agricultural and Biological Chemistry, 55, 1201–3.
Ohigashi, H., Huffman, M. A., Izutsu, D., et al. (1994). Toward the chemical ecology of medicinal plant-use in chimpanzees: the case of Vernonia amygdalina Del., a plant used by wild chimpanzees possibly for parasite-related diseases. Journal of Chemical Ecology, 20, 541–53.
Page, J. E., Balza, F. F., Nishida, T., and Towers, G. H. N. (1992). Biologically active diterpenes from Aspilia mossambicensis, a chimpanzee medicinal plant. Phytochemistry, 31, 3437–9.
Page, J. E., Huffman, M. A., Smith, V., and Towers, G. H. N. (1997). Chemical basis for medicinal consumption of Aspilia leaves by chimpanzees: a re-analysis. Journal of Chemical Ecology, 23, 2211–25.
Pebsworth, P., Krief, S., and Huffman, M. A. (2006). The role of diet in self-medication among chimpanzees in the Sonso and Kanyawara communities, Uganda. In Primates of Western Uganda, ed. Newton-Fisher, N. E., Notman, H., Reynolds, V., and Paterson, J. D.. New York: Springer, pp. 105–33.
Rodriguez, E. and Wrangham, R. W. (1993). Zoopharmacognosy: the use of medicinal plants by animals. In Recent Advances in Phytochemistry: Vol. 27. Phytochemical Potential of Tropic Plants. ed. Downum, K. R., Romeo, J. T., and Stafford, H.. New York: Plenum Press, pp. 89105.
Rodriguez, E., Aregullin, M., Nishida, T., et al. (1985). Thiarubrine A, a bioactive constituent of Aspilia (Asteraceae) consumed by wild chimpanzees. Experientia, 41, 419–20.
Sapolsky, R. M. (1998). The Trouble with Testosterone: And Other Essays on The Biology of the Human Predicament. New York: Simon & Schuster.
Su, H., Su, Y., and Huffman, M. A. (2013). Leaf-swallowing and parasite infection in the Chinese lesser civet (Viverricula indica) in northern Taiwan. Zoological Studies, 52, 22.
Suárez-Rodríguez, M., López-Rull, I., and Macías Garcia, C. (2013). Incorporation of cigarette butts into nests reduces nest ectoparasite load in urban birds: new ingredients for an old recipe? Biology Letters, 9, 20120931.
Takasaki, H. and Hunt, K. (1987). Further medicinal plant consumption in wild chimpanzees? African Studies Monographs, 8, 125–8.
Toubiana, R. and Gaudemer, A. (1967). Structure du vernolide, nouvel ester sesquiterpique isole de Vernonia colorata. Tetrahedron Letters, 14, 1333–6. In French.
Towers, G. H. N., Abramowski, Z., Finlayson, A. J., and Zucconi, A. (1985). Antibiotic properties of thiarubrine-A, a naturally occurring dithiacyclohedadiene polyine. Planta Medica, 3, 225–9.
Villalba, J. J. and Landau, S. Y. (2012). Host behavior, environment and the ability to self-medicate. Small Ruminant Research, 103, 50–9.
Watt, J. M. and Breyer-Brandwinjk, M. G. (1962). The Medicinal and Poisonous Plants of Southern and East Africa. Edinburgh: E. and S. Livingstone.
Wink, M., Hofer, A., Bilfinger, M., et al. (1993). Geese and dietary allelochemicals: food palatability and geophagy. Chemoecology, 4, 93107.
Wrangham, R. W. (1975). The Behavioural Ecology of Chimpanzees in Gombe National Park, Tanzania. Ph.D. thesis. Cambridge: University of Cambridge.
Wrangham, R. W. (1995). Relationship of chimpanzee leaf-swallowing to a tapeworm infection. American Journal of Primatology, 37, 297303.
Wrangham, R. W. and Nishida, T. (1983). Aspilia spp. leaves: a puzzle in the feeding behavior of wild chimpanzees. Primates, 24, 276–82.