Book contents
- Marijuana and Madness
- Marijuana and Madness
- Copyright page
- Contents
- Contributors
- Preface
- Part I Pharmacology of Cannabis and the Endocannabinoid System
- Part II The Changing Face of Cannabis
- Part III Cannabis and the Brain
- Chapter 7 The Impact of Adolescent Exposure to Cannabis on the Brain
- Chapter 8 The Impact of Cannabis Exposure on the Adolescent Brain
- Chapter 9 Cannabis and Cognition
- Chapter 10 Is There a Cannabis-Associated Psychosis Sub-type?
- Part IV Cannabis, Anxiety, and Mood
- Part V Cannabis and Psychosis
- Part VI Cannabinoids and Schizophrenia: Aetiopathology and Treatment Implications
- Part VII Cannabinoids and Schizophrenia: Aetiopathology and Treatment Implications
- Part VIII Special Topics
- Index
- References
Chapter 10 - Is There a Cannabis-Associated Psychosis Sub-type?
Lessons from Biological Typing in the B-SNIP Project and Implications for Treatment
from Part III - Cannabis and the Brain
Published online by Cambridge University Press: 12 May 2023
- Marijuana and Madness
- Marijuana and Madness
- Copyright page
- Contents
- Contributors
- Preface
- Part I Pharmacology of Cannabis and the Endocannabinoid System
- Part II The Changing Face of Cannabis
- Part III Cannabis and the Brain
- Chapter 7 The Impact of Adolescent Exposure to Cannabis on the Brain
- Chapter 8 The Impact of Cannabis Exposure on the Adolescent Brain
- Chapter 9 Cannabis and Cognition
- Chapter 10 Is There a Cannabis-Associated Psychosis Sub-type?
- Part IV Cannabis, Anxiety, and Mood
- Part V Cannabis and Psychosis
- Part VI Cannabinoids and Schizophrenia: Aetiopathology and Treatment Implications
- Part VII Cannabinoids and Schizophrenia: Aetiopathology and Treatment Implications
- Part VIII Special Topics
- Index
- References
Summary
‘Cannabis-associated psychosis’ (CAP) refers to a chronic psychotic illness that arises in the context of significant current or past cannabis use. This chapter is an interrogation of the large-scale, multi-centre cross-sectional study of individuals with an established psychotic illness, the bipolar–schizophrenia network on intermediate phenotypes (B-SNIP). B-SNIP used biological characteristics to sub-divide individuals with psychotic illnesses into distinct sub-group,s known as ‘Biotypes’. A subtype associated with adolescent cannabis exposure, Biotype-3, was characterized to have the distinct profile of a significant excess of adolescent cannabis use histories preceding the onset of psychosis, histories of childhood abuse, distinctly preserved cognition, hippocampal morphological and neurochemical abnormalities, normal evoked and resting electrophysiology, more normal MRI grey matter patterns, near-normal saccades and smooth pursuit eye movements, and the lowest schizophrenia polygenic risk scores. Further work is necessary to study CAP in order to find treatments specific for CAP.
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- Information
- Marijuana and Madness , pp. 91 - 106Publisher: Cambridge University PressPrint publication year: 2023