Skip to main content Accessibility help
×
Hostname: page-component-848d4c4894-nr4z6 Total loading time: 0 Render date: 2024-06-01T06:19:01.760Z Has data issue: false hasContentIssue false

8 - Role of endoscopic ultrasound in diagnosis and staging of pancreatic neoplasms

Published online by Cambridge University Press:  23 December 2009

Jay Heiken
Affiliation:
Mallinckrodt Institute of Radiology
Get access

Summary

Introduction

Endoscopic ultrasound (EUS) was developed in the 1980s to address, in part, the limitations of transabdominal ultrasound imaging of the abdomen. Adequate ultrasonography relies on the transmission of sound waves. Thus imaging of the abdomen by external ultrasonography is limited by interference of bowel gas. Endoscopic ultrasound reduces bowel gas interference by placing the ultrasound transducer directly within the gastrointestinal lumen via endoscopy. Thus, merging the technologies of endoscopy and ultrasonography allows the trained endosonographer to obtain detailed images of the pancreas, among many other uses.

Endoscopic ultrasound is generally performed in an endoscopy facility with the availability of skilled nurses or technicians, sedation and appropriate endoscopic equipment (Figure 8.1) [1]. Upper EUS is routinely performed after an overnight fast and is most often completed in the outpatient setting. Patients are placed under intravenous conscious sedation or monitored anesthesia care, and the procedure is completed in 30–60 minutes, depending on the complexity of the examination. Endoscopic ultrasound accuracy is dependent on a number of factors including the quality of available equipment, operator experience in technique and interpretation, and patient anatomy and body habitus. There is a recognized learning curve for the performance of accurate EUS examinations and, as with standard ultrasonography, accuracy improves with increased experience [2].

Endoscopic ultrasound imaging of the pancreas can be performed via either radial or linear echoendoscopes (Figure 8.2). Radial echoendoscopes provide a complete, 360-degree image perpendicular to the axis of the endoscope.

Type
Chapter
Information
Pancreatic Cancer , pp. 130 - 149
Publisher: Cambridge University Press
Print publication year: 2008

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Liu, J, Carpenter, S, Chuttani, R, et al. Endoscopic ultrasound probes. Gastrointest Endosc 2006; 63(6): 751–754.CrossRefGoogle ScholarPubMed
Eloubeidi, MA, Tamhane, A. EUS-guided FNA of solid pancreatic masses: a learning curve with 300 consecutive procedures. Gastrointest Endosc 2005; 61(6): 700–708.CrossRefGoogle ScholarPubMed
Oh, YS, Early, DS, Azar, RR. Clinical applications of endoscopic ultrasound to oncology. Oncology 2005; 68(4–6): 526–537.CrossRefGoogle ScholarPubMed
Yasuda, K, Mukai, H, Nakajima, M. Endoscopic ultrasonography diagnosis of pancreatic cancer. Gastrointest Endosc Clin N Am 1995; 5(4): 699–712.Google ScholarPubMed
Hunt, GC, Faigel, . Assessment of EUS for diagnosing, staging, and determining resectability of pancreatic cancer: a review. Gastrointest Endosc 2002; 55(2): 232–237.CrossRefGoogle ScholarPubMed
Mertz, HR, Sechopoulos, P, Delbeke, D, Leach, SD. EUS, PET, and CT scanning for evaluation of pancreatic adenocarcinoma. Gastrointest Endosc 2000; 52(3): 367–371.CrossRefGoogle ScholarPubMed
DeWitt, J, Devereaux, B, Chriswell, M, et al. Comparison of endoscopic ultrasonography and multidetector computed tomography for detecting and staging pancreatic cancer. Ann Intern Med 2004; 141(10): 753–763.CrossRefGoogle ScholarPubMed
Dewitt, J, Devereaux, BM, Lehman, GA, Sherman, S, Imperiale, TF. Comparison of endoscopic ultrasound and computed tomography for the preoperative evaluation of pancreatic cancer: a systematic review. Clin Gastroenterol Hepatol 2006; 4(6): 717–725; quiz 664.CrossRefGoogle ScholarPubMed
Borbath, I, Beers, BE, Lonneux, M, et al. Preoperative assessment of pancreatic tumors using magnetic resonance imaging, endoscopic ultrasonography, positron emission tomography and laparoscopy. Pancreatology 2005; 5(6): 553–561.CrossRefGoogle ScholarPubMed
Tamm, EP, Loyer, EM, Faria, SC, et al. Retrospective analysis of dual-phase MDCT and follow-up EUS/EUS-FNA in the diagnosis of pancreatic cancer. Abdom Imaging 2007; 32: 660–667.CrossRefGoogle Scholar
Raut, CP, Grau, AM, Staerkel, GA, et al. Diagnostic accuracy of endoscopic ultrasound-guided fine-needle aspiration in patients with presumed pancreatic cancer. J Gastrointest Surg 2003; 7(1): 118–126; discussion 127–128.CrossRefGoogle ScholarPubMed
Shin, HJ, Lahoti, S, Sneige, N. Endoscopic ultrasound-guided fine-needle aspiration in 179 cases: the M. D. Anderson Cancer Center experience. Cancer 2002; 96(3): 174–180.CrossRefGoogle Scholar
Klapman, JB, Logrono, R, Dye, CE, Waxman, I. Clinical impact of on-site cytopathology interpretation on endoscopic ultrasound-guided fine needle aspiration. Am J Gastroenterol 2003; 98(6): 1289–1294.CrossRefGoogle ScholarPubMed
LeBlanc, JK, Ciaccia, D, Al-Assi, MT, et al. Optimal number of EUS-guided fine needle passes needed to obtain a correct diagnosis. Gastrointest Endosc 2004; 59(4): 475–481.CrossRefGoogle ScholarPubMed
Eloubeidi, MA, Tamhane, A, Varadarajulu, S, Wilcox, CM. Frequency of major complications after EUS-guided FNA of solid pancreatic masses: a prospective evaluation. Gastrointest Endosc 2006; 63(4): 622–629.CrossRefGoogle ScholarPubMed
Eloubeidi, MA, Varadarajulu, S, Desai, S, et al. A prospective evaluation of an algorithm incorporating routine preoperative endoscopic ultrasound-guided fine needle aspiration in suspected pancreatic cancer. J Gastrointest Surg 2007; 11: 813–819.CrossRefGoogle ScholarPubMed
Varadarajulu, S, Tamhane, A, Eloubeidi, MA. Yield of EUS-guided FNA of pancreatic masses in the presence or the absence of chronic pancreatitis. Gastrointest Endosc 2005; 62(5): 728–736; quiz 751, 753.CrossRefGoogle ScholarPubMed
Ardengh, JC, Lopes, CV, Campos, AD, et al. Endoscopic ultrasound and fine needle aspiration in chronic pancreatitis: differential diagnosis between pseudotumoral masses and pancreatic cancer. J Pancreas 2007; 8(4): 413–421.Google ScholarPubMed
Fritscher-Ravens, A, Brand, L, Knofel, WT, et al. Comparison of endoscopic ultrasound-guided fine needle aspiration for focal pancreatic lesions in patients with normal parenchyma and chronic pancreatitis. Am J Gastroenterol 2002; 97(11): 2768–2775.CrossRefGoogle ScholarPubMed
A, Khalid, Nodit, L, Zahid, M, et al. Endoscopic ultrasound fine needle aspirate DNA analysis to differentiate malignant and benign pancreatic masses. Am J Gastroenterol 2006; 101(11): 2493–2500.Google Scholar
Bergenfeldt, M, Genell, S, Lindholm, K, Ekberg, O, Aspelin, P. Needle-tract seeding after percutaneous fine-needle biopsy of pancreatic carcinoma. Case report. Acta Chir Scand 1988; 154(1): 77–79.Google ScholarPubMed
Bret, PM, Nicolet, V, Labadie, M. Percutaneous fine-needle aspiration biopsy of the pancreas. Diagn Cytopathol 1986; 2(3): 221–227.CrossRefGoogle ScholarPubMed
Fornari, F, Civardi, G, Cavanna, L, et al. Complications of ultrasonically guided fine-needle abdominal biopsy. Results of a multicenter Italian study and review of the literature. The Cooperative Italian Study Group. Scand J Gastroenterol 1989; 24(8): 949–955.CrossRefGoogle ScholarPubMed
Micames, C, Jowell, PS, White, R, et al. Lower frequency of peritoneal carcinomatosis in patients with pancreatic cancer diagnosed by EUS-guided FNA vs. percutaneous FNA. Gastrointest Endosc 2003; 58(5): 690–695.CrossRefGoogle ScholarPubMed
Horwhat, JD, Paulson, EK, McGrath, K, et al. A randomized comparison of EUS-guided FNA versus CT or US-guided FNA for the evaluation of pancreatic mass lesions. Gastrointest Endosc 2006; 63(7): 966–975.CrossRefGoogle ScholarPubMed
Harewood, GC, Wiersema, MJ, Nelson, H, et al. A prospective, blinded assessment of the impact of preoperative staging on the management of rectal cancer. Gastroenterology 2002; 123(1): 24–32.CrossRefGoogle ScholarPubMed
Snady, H, Bruckner, H, Siegel, J, et al. Endoscopic ultrasonographic criteria of vascular invasion by potentially resectable pancreatic tumors. Gastrointest Endosc 1994; 40(3): 326–333.CrossRefGoogle ScholarPubMed
Buscail, L, Pages, P, Berthelemy, P, et al. Role of EUS in the management of pancreatic and ampullary carcinoma: a prospective study assessing resectability and prognosis. Gastrointest Endosc 1999; 50(1): 34–40.CrossRefGoogle ScholarPubMed
Brugge, WR, Lee, MJ, Kelsey, PB, Schapiro, RH, Warshaw, AL. The use of EUS to diagnose malignant portal venous system invasion by pancreatic cancer. Gastrointest Endosc 1996; 43(6): 561–567.CrossRefGoogle ScholarPubMed
Rosch, T, Dittler, HJ, Strobel, K, et al. Endoscopic ultrasound criteria for vascular invasion in the staging of cancer of the head of the pancreas: a blind reevaluation of videotapes. Gastrointest Endosc 2000; 52(4): 469–477.CrossRefGoogle ScholarPubMed
Puli, SR, Singh, S, Hagedorn, CH, Reddy, J, Olyaee, M. Diagnostic accuracy of EUS for vascular invasion in pancreatic and periampullary cancers: a meta-analysis and systematic review. Gastrointest Endosc 2007; 65(6): 788–797.CrossRefGoogle ScholarPubMed
Snady, H. EUS criteria for vascular invasion: analyzing the meta-analysis. Gastrointest Endosc 2007; 65(6): 798–807.CrossRefGoogle ScholarPubMed
Neoptolemos, JP. Is endoscopic ultrasonography superior to multidetector CT for assessing pancreatic cancer?Nat Clin Pract Oncol 2005; 2(2): 78–79.CrossRefGoogle ScholarPubMed
Ahmad, NA, Lewis, JD, Siegelman, ES, et al. Role of endoscopic ultrasound and magnetic resonance imaging in the preoperative staging of pancreatic adenocarcinoma. Am J Gastroenterol 2000; 95(8): 1926–1931.CrossRefGoogle ScholarPubMed
Fernandez-del, Castillo C, Targarona, J, Thayer, SP, et al. Incidental pancreatic cysts: clinicopathologic characteristics and comparison with symptomatic patients. Arch Surg 2003; 138(4): 427–433; discussion 433–434.Google Scholar
Michael, H, Gress, F. Diagnosis of cystic neoplasms with endoscopic ultrasound. Gastrointest Endosc Clin N Am 2002; 12(4): 719–733.CrossRefGoogle ScholarPubMed
Balcom, IJ, Fernandez-Del, Castillo C, Warshaw, AL. Cystic lesions in the pancreas: when to watch, when to resect. Curr Gastroenterol Rep 2000; 2(2): 152–158.CrossRefGoogle Scholar
Borgne, J, Calan, L, Partensky, C. Cystadenomas and cystadenocarcinomas of the pancreas: a multiinstitutional retrospective study of 398 cases. French Surgical Association. Ann Surg 1999; 230(2): 152–161.CrossRefGoogle ScholarPubMed
Warshaw, AL, Compton, CC, Lewandrowski, K, Cardenosa, G, Mueller, PR. Cystic tumors of the pancreas. New clinical, radiologic, and pathologic observations in 67 patients. Ann Surg 1990; 212(4): 432–443; discussion 444–445.CrossRefGoogle ScholarPubMed
Compagno, J, Oertel, JE. Microcystic adenomas of the pancreas (glycogen-rich cystadenomas): a clinicopathologic study of 34 cases. Am J Clin Pathol 1978; 69(3): 289–298.CrossRefGoogle ScholarPubMed
Longnecker, DS, Adler, G, Hruban, RH, Kloppel, G. World Health Organization Classification of Tumors. Lyon, IARC Press. 2000.Google Scholar
Spinelli, KS, Fromwiller, TE, Daniel, RA, et al. Cystic pancreatic neoplasms: observe or operate. Ann Surg 2004; 239(5): 651–657; discussion 657–659.CrossRefGoogle ScholarPubMed
Brugge, WR. Evaluation of pancreatic cystic lesions with EUS. Gastrointest Endosc 2004; 59(6): 698–707.CrossRefGoogle ScholarPubMed
Brugge, WR. Role of endoscopic ultrasound in the diagnosis of cystic lesions of the pancreas. Pancreatology 2001; 1(6): 637–640.CrossRefGoogle Scholar
Van, Dam J. EUS in cystic lesions of the pancreas. Gastrointest Endosc 2002; 56(4 Suppl): S91–S93.Google Scholar
Ariyama, J, Suyama, M, Satoh, K, Wakabayashi, K. Endoscopic ultrasound and intraductal ultrasound in the diagnosis of small pancreatic tumors. Abdom Imaging 1998; 23(4): 380–386.CrossRefGoogle Scholar
Gress, F, Gottlieb, K, Cummings, O, Sherman, S, Lehman, G. Endoscopic ultrasound characteristics of mucinous cystic neoplasms of the pancreas. Am J Gastroenterol 2000; 95(4): 961–965.CrossRefGoogle ScholarPubMed
Koito, K, Namieno, T, Nagakawa, T, et al. Solitary cystic tumor of the pancreas: EUS-pathologic correlation. Gastrointest Endosc 1997; 45(3): 268–276.CrossRefGoogle ScholarPubMed
Ahmad, NA, Kochman, ML, Lewis, JD, Ginsberg, GG. Can EUS alone differentiate between malignant and benign cystic lesions of the pancreas?Am J Gastroenterol 2001; 96(12): 3295–3300.CrossRefGoogle ScholarPubMed
Ahmad, NA, Kochman, ML, Brensinger, C, et al. Interobserver agreement among endosonographers for the diagnosis of neoplastic versus non-neoplastic pancreatic cystic lesions. Gastrointest Endosc 2003; 58(1): 59–64.CrossRefGoogle Scholar
Frossard, JL, Amouyal, P, Amouyal, G, et al. Performance of endosonography-guided fine needle aspiration and biopsy in the diagnosis of pancreatic cystic lesions. Am J Gastroenterol 2003; 98(7): 1516–1524.CrossRefGoogle Scholar
Brugge, WR, Lewandrowski, K, Lee-Lewandrowski, E, et al. Diagnosis of pancreatic cystic neoplasms: a report of the cooperative pancreatic cyst study. Gastroenterology 2004; 126(5): 1330–1336.CrossRefGoogle ScholarPubMed
Recine, M, Kaw, M, Evans, DB, Krishnamurthy, S. Fine-needle aspiration cytology of mucinous tumors of the pancreas. Cancer 2004; 102(2): 92–99.CrossRefGoogle ScholarPubMed
Hammel, P, Levy, P, Voitot, H, et al. Preoperative cyst fluid analysis is useful for the differential diagnosis of cystic lesions of the pancreas. Gastroenterology 1995; 108(4): 1230–1235.CrossRefGoogle ScholarPubMed
Lewandrowski, KB, Southern, JF, Pins, MR, Compton, CC, Warshaw, AL. Cyst fluid analysis in the differential diagnosis of pancreatic cysts. A comparison of pseudocysts, serous cystadenomas, mucinous cystic neoplasms, and mucinous cystadenocarcinoma. Ann Surg 1993; 217(1): 41–47.CrossRefGoogle ScholarPubMed
Moparty, B, Sluss, PM, Melanson, SE, Lewandrowski, KB, Brugge, WR. Pancreatic cyst fluid CEA: Caution! Diagnostic cutoff values are assay system dependent. Gastrointest Endosc 2007; 65(5): AB300.CrossRefGoogle Scholar
, Waaij, Dullemen, HM, Porte, RJ. Cyst fluid analysis in the differential diagnosis of pancreatic cystic lesions: a pooled analysis. Gastrointest Endosc 2005; 62(3): 383–389.Google Scholar
Shami, VM, Sundaram, V, Stelow, EB, et al. The level of carcinoembryonic antigen and the presence of mucin as predictors of cystic pancreatic mucinous neoplasia. Pancreas 2007; 34(4): 466–469.CrossRefGoogle ScholarPubMed
Linder, JD, Geenen, JE, Catalano, MF. Cyst fluid analysis obtained by EUS-guided FNA in the evaluation of discrete cystic neoplasms of the pancreas: a prospective single-center experience. Gastrointest Endosc 2006; 64(5): 697–702.CrossRefGoogle ScholarPubMed
Khalid, A, McGrath, KM, Zahid, M, et al. The role of pancreatic cyst fluid molecular analysis in predicting cyst pathology. Clin Gastroenterol Hepatol 2005; 3(10): 967–973.CrossRefGoogle ScholarPubMed
Oberg, K, Eriksson, B. Endocrine tumours of the pancreas. Best Pract Res Clin Gastroenterol 2005; 19(5): 753–781.CrossRefGoogle ScholarPubMed
Anderson, MA, Carpenter, S, Thompson, NW, et al. Endoscopic ultrasound is highly accurate and directs management in patients with neuroendocrine tumors of the pancreas. Am J Gastroenterol 2000; 95(9): 2271–2277.CrossRefGoogle ScholarPubMed
De, Angelis C, Repici, A, Arena, V, Pellicano, R, Rizzetto, M. Preoperative endoscopic ultrasonography in decision making and management for pancreatic endocrine tumors: a 6-year experience. Endoscopy 1998; 30 Suppl 1: A182–A186.Google Scholar
Gouya, H, Vignaux, O, Augui, J, et al. CT, endoscopic sonography, and a combined protocol for preoperative evaluation of pancreatic insulinomas. Am J Roentgenol 2003; 181(4): 987–992.CrossRefGoogle Scholar
Palazzo, L, Roseau, G, Chaussade, S, et al. Pancreatic endocrine tumors: contribution of ultrasound endoscopy in the diagnosis of localization. Ann Chir 1993; 47(5): 419–424.Google Scholar
Zimmer, T, Stolzel, U, Bader, M, et al. Endoscopic ultrasonography and somatostatin receptor scintigraphy in the preoperative localisation of insulinomas and gastrinomas. Gut 1996; 39(4): 562–568.CrossRefGoogle ScholarPubMed
Rosch, T, Lightdale, CJ, Botet, JF, et al. Localization of pancreatic endocrine tumors by endoscopic ultrasonography. N Engl J Med 1992; 326(26): 1721–1726.CrossRefGoogle ScholarPubMed
McLean, AM, Fairclough, PD. Endoscopic ultrasound in the localisation of pancreatic islet cell tumours. Best Pract Res Clin Endocrinol Metab 2005; 19(2): 177–193.CrossRefGoogle ScholarPubMed
Fidler, JL, Fletcher, JG, Reading, CC, et al. Preoperative detection of pancreatic insulinomas on multiphasic helical CT. Am J Roentgenol 2003; 181(3): 775–780.CrossRefGoogle ScholarPubMed
Legmann, P, Vignaux, O, Dousset, B, et al. Pancreatic tumors: comparison of dual-phase helical CT and endoscopic sonography. Am J Roentgenol 1998; 170(5): 1315–1322.CrossRefGoogle ScholarPubMed
Rappeport, ED, Hansen, CP, Kjaer, A, Knigge, U. Multidetector computed tomography and neuroendocrine pancreaticoduodenal tumors. Acta Radiol 2006; 47(3): 248–256.CrossRefGoogle ScholarPubMed
Rockall, AG, Reznek, RH. Imaging of neuroendocrine tumours (CT/MR/US). Best Pract Res Clin Endocrinol Metab 2007; 21(1): 43–68.CrossRefGoogle Scholar
Lebtahi, R, Cadiot, G, Sarda, L, et al. Clinical impact of somatostatin receptor scintigraphy in the management of patients with neuroendocrine gastroenteropancreatic tumors. J Nucl Med 1997; 38(6): 853–858.Google ScholarPubMed
Chang, F, Vu, C, Chandra, A, Meenan, J, Herbert, A. Endoscopic ultrasound-guided fine needle aspiration cytology of pancreatic neuroendocrine tumours: cytomorphological and immunocytochemical evaluation. Cytopathology 2006; 17(1): 10–17.CrossRefGoogle ScholarPubMed
Ardengh, JC, Paulo, GA, Ferrari, AP. EUS-guided FNA in the diagnosis of pancreatic neuroendocrine tumors before surgery. Gastrointest Endosc 2004; 60(3): 378–384.CrossRefGoogle Scholar
Gines, A, Vazquez-Sequeiros, E, Soria, MT, Clain, JE, Wiersema, MJ. Usefulness of EUS-guided fine needle aspiration (EUS-FNA) in the diagnosis of functioning neuroendocrine tumors. Gastrointest Endosc 2002; 56(2): 291–296.CrossRefGoogle Scholar
Gress, FG, Barawi, M, Kim, D, Grendell, JH. Preoperative localization of a neuroendocrine tumor of the pancreas with EUS-guided fine needle tattooing. Gastrointest Endosc 2002; 55(4): 594–597.CrossRefGoogle ScholarPubMed
Bansal, R, Tierney, W, Carpenter, S, Thompson, N, Scheiman, JM. Cost effectiveness of EUS for preoperative localization of pancreatic endocrine tumors. Gastrointest Endosc 1999; 49(1): 19–25.CrossRefGoogle ScholarPubMed

Save book to Kindle

To save this book to your Kindle, first ensure coreplatform@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about saving to your Kindle.

Note you can select to save to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be saved to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

Find out more about the Kindle Personal Document Service.

Available formats
×

Save book to Dropbox

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Dropbox.

Available formats
×

Save book to Google Drive

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Google Drive.

Available formats
×