Skip to main content Accessibility help
×
Hostname: page-component-848d4c4894-m9kch Total loading time: 0 Render date: 2024-05-10T10:39:34.227Z Has data issue: false hasContentIssue false

Chapter 7 - Pleomorphic Sarcomas

Published online by Cambridge University Press:  10 May 2019

Angelo Paolo Dei Tos
Affiliation:
Università degli Studi di Padova, Italy
Get access

Summary

Image of the first page of this content. For PDF version, please use the ‘Save PDF’ preceeding this image.'
Type
Chapter
Information
Soft Tissue Sarcomas
A Pattern-Based Approach to Diagnosis
, pp. 363 - 417
Publisher: Cambridge University Press
Print publication year: 2018

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Primary Sources

Angervall, L, Kindblom, LG, Merck, C. Myxofibrosarcoma. A study of 30 cases. Acta Pathol Microbiol Scand A. 1977;85A:127–40.Google Scholar
Cipriani, NA, Kurzawa, P, Ahmad, RA, et al. Prognostic value of myogenic differentiation in undifferentiated pleomorphic sarcomas of soft tissue. Hum Pathol. 2014;45:1504–8.CrossRefGoogle ScholarPubMed
Coindre, JM, Hostein, I, Maire, G, et al. Inflammatory malignant fibrous histiocytomas and dedifferentiated liposarcomas: histological review, genomic profile, and MDM2 and CDK4 status favour a single entity. J Pathol. 2004;203:822–30.Google Scholar
Dahlin, DC, Beabout, JW. Dedifferentiation of low-grade chondrosarcomas. Cancer. 1971;28:461–6.Google Scholar
Dei Tos, AP. Classification of pleomorphic sarcomas: where are we now? Histopathology. 2006;48:5162.CrossRefGoogle ScholarPubMed
Deyrup, AT, Haydon, RC, Huo, D, et al. Myoid differentiation and prognosis in adult pleomorphic sarcomas of the extremity: an analysis of 92 cases. Cancer. 2003;15(98):805–13.Google Scholar
Enzinger, FM. Angiomatoid malignant fibrous histiocytoma: a distinct fibrohistiocytic tumor of children and young adults simulating a vascular neoplasm. Cancer. 1979;44:2147–57.Google Scholar
Enzinger, FM. Malignant fibrous histiocytoma 20 years after Stout. Am J Surg Pathol. 1986;10 Suppl 1:4353.Google ScholarPubMed
Evans, HL. Liposarcoma: a study of 55 cases with a reassessment of its classification. Am J Surg Pathol. 1979;3:507–23.Google Scholar
Fletcher, CD. Angiomatoid “malignant fibrous histiocytoma”: an immunohistochemical study indicative of myoid differentiation. Hum Pathol. 1991;22:563–8.CrossRefGoogle ScholarPubMed
Fletcher, CD. Pleomorphic malignant fibrous histiocytoma: fact or fiction? A critical reappraisal based on 159 tumors diagnosed as pleomorphic sarcoma. Am J Surg Pathol. 1992;16:213–28.Google Scholar
Fletcher, CD, Gustafson, P, Rydholm, A, Willén, H, Akerman, M. Clinicopathologic re-evaluation of 100 malignant fibrous histiocytomas: prognostic relevance of subclassification. J Clin Oncol. 2001;19:3045–50.Google Scholar
Guccion, JG, Enzinger, FM. Malignant giant cell tumor of soft parts. An analysis of 32 cases. Cancer. 1972;29:1518–29.Google Scholar
Mentzel, T, Calonje, E, Fletcher, CD. Leiomyosarcoma with prominent osteoclast-like giant cells. Analysis of eight cases closely mimicking the so-called giant cell variant of malignant fibrous histiocytoma. Am J Surg Pathol. 1994;18:258–65.CrossRefGoogle ScholarPubMed
Merck, C, Angervall, L, Kindblom, LG, et al. Myxofibrosarcoma. A malignant soft tissue tumor of fibroblastic-histiocytic origin. A clinicopathologic and prognostic study of 110 cases using multivariate analysis. Acta Pathol Microbiol Immunol Scand Suppl. 1983;282: 140.Google Scholar
Ozzello, L, Stout, AP, Murray, MR. Cultural characteristics of malignant histiocytomas and fibrous xanthomas. Cancer. 1963;16:331–44.Google Scholar
Salm, R, Sissons, HA. Giant-cell tumours of soft tissues. J Pathol. 1972;107:2739.Google Scholar
Weiss, SW, Enzinger, FM. Myxoid variant of malignant fibrous histiocytoma. Cancer. 1977;39:1672–85.Google Scholar
Weiss, SW, Enzinger, FM. Malignant fibrous histiocytoma: an analysis of 200 cases. Cancer 1978;41:2250–66.Google Scholar

Secondary Sources

de Jong, AS, van Kessel-van Vark, M, Albus-Lutter, CE. Pleomorphic rhabdomyosarcoma in adults: immunohistochemistry as a tool for its diagnosis. Hum Pathol. 1987;18:298303.Google Scholar
Fadare, O, Bonvicino, A, Martel, M, et al. Pleomorphic rhabdomyosarcoma of the uterine corpus: a clinicopathologic study of 4 cases and a review of the literature. Int J Gynecol Pathol. 2010;29:122–34.Google Scholar
Furlong, MA, Fanburg-Smith, JC. Pleomorphic rhabdomyosarcoma in children: four cases in the pediatric age group. Ann Diagn Pathol. 2001;5:199206.CrossRefGoogle ScholarPubMed
Furlong, MA, Mentzel, T, Fanburg-Smith, JC. Pleomorphic rhabdomyosarcoma in adults: a clinicopathologic study of 38 cases with emphasis on morphologic variants and recent skeletal muscle-specific markers. Mod Pathol. 2001;14:595603.Google Scholar
Gaffney, EF, Dervan, PA, Fletcher, CD. Pleomorphic rhabdomyosarcoma in adulthood. Analysis of 11 cases with definition of diagnostic criteria. Am J Surg Pathol. 1993;17:601–9.Google ScholarPubMed
Gagné, E, Têtu, B, Blondeau, L, Raymond, PE, Blais, R. Morphologic prognostic factors of malignant mixed müllerian tumor of the uterus: a clinicopathologic study of 58 cases. Mod Pathol. 1989;2:433–8.Google ScholarPubMed
Keyhani, A, Booher, RJ. Pleomorphic rhabdomyosarcoma. Cancer. 1968;22:956–67.3.0.CO;2-4>CrossRefGoogle ScholarPubMed
Li, G, Ogose, A, Kawashima, H, et al. Cytogenetic and real-time quantitative reverse-transcriptase polymerase chain reaction analyses in pleomorphic rhabdomyosarcoma. Cancer Genet Cytogenet. 2009;192:19.CrossRefGoogle ScholarPubMed
Noujaim, J, Thway, K, Jones, RL, et al. Adult pleomorphic rhabdomyosarcoma: a multicentre retrospective study. Anticancer Res. 2015;35:6213–17.Google Scholar
Sternberg, WH, Clark, WH, Smith, RC. Malignant mixed müllerian tumor (mixed mesodermal tumor of the uterus); a study of twenty-one cases. Cancer. 1954;7:704–24.Google Scholar
Stout, AP. Rhabdomyosarcoma of the skeletal muscles. Ann Surg. 1946;123:447–72.Google Scholar
Creytens, D, Mentzel, T, Ferdinande, L, et al. “Atypical” pleomorphic lipomatous tumor: a clinicopathologic, immunohistochemical and molecular study of 21 cases, emphasizing its relationship to atypical spindle cell lipomatous tumor and suggesting a morphologic spectrum (atypical spindle cell/pleomorphic lipomatous tumor). Am J Surg Pathol. 2017;41:1443–55.Google Scholar
Dei Tos, AP. Liposarcomas: diagnostic pitfalls and new insights. Histopathology. 2014;64:3852.Google Scholar
Dei Tos, AP, Mentzel, T, Fletcher, CDM. Primary liposarcoma of the skin: a rare neoplasm with unusual high grade features. Am J Dermatopathol.1998;20:332–8.Google Scholar
Downes, KA, Goldblum, JR, Montgomery, EA, Fisher, C. Pleomorphic liposarcoma: a clinicopathologic analysis of 19 cases. Mod Pathol. 2001;14:179–84.Google Scholar
Gardner, JM, Dandekar, M, Thomas, D, et al. Cutaneous and subcutaneous pleomorphic liposarcoma: a clinicopathologic study of 29 cases with evaluation of MDM2 gene amplification in 26. Am J Surg Pathol. 2012;36:1047–51.Google Scholar
Gebhard, S, Coindre, JM, Michels, JJ, et al. Pleomorphic liposarcoma: clinicopathologic, immunohistochemical, and follow-up analysis of 63 cases: a study from the French Federation of Cancer Centers Sarcoma Group. Am J Surg Pathol. 2002;26:601–16.Google Scholar
Ghadimi, MP, Liu, P, Peng, T, et al. Pleomorphic liposarcoma: clinical observations and molecular variables. Cancer. 2011;117:5359–69.Google Scholar
Hornick, JL, Bosenberg, MW, Mentzel, T, et al. Pleomorphic liposarcoma: clinicopathologic analysis of 57 cases. Am J Surg Pathol. 2004;28:1257–67.Google Scholar
Mariño-Enríquez, A, Fletcher, CD, Dal Cin, P, Hornick, JL. Dedifferentiated liposarcoma with “homologous” lipoblastic (pleomorphic liposarcoma-like) differentiation: clinicopathologic and molecular analysis of a series suggesting revised diagnostic criteria. Am J Surg Pathol. 2010;34:1122–31.CrossRefGoogle ScholarPubMed
Miettinen, M, Enzinger, FM. Epithelioid variant of pleomorphic liposarcoma: a study of 12 cases of a distinctive variant of high-grade liposarcoma. Mod Pathol. 1999;12:722–8.Google Scholar
Oliveira, AM, Nascimento, AG. Pleomorphic liposarcoma. Semin Diagn Pathol. 2001;18:274–85.Google Scholar
Shmookler, BM, Enzinger, FM. Pleomorphic lipoma: a benign tumor simulating liposarcoma. A clinicopathologic analysis of 48 cases. Cancer. 1981;1(47):126–33.Google Scholar
Tandon, B, Hagemann, IS, Maluf, HM, Pfeifer, JD, Al-Kateb, H. Association of Li-Fraumeni syndrome with small cell carcinoma of the ovary, hypercalcemic type and concurrent pleomorphic liposarcoma of the cervix. Int J Gynecol Pathol. 2017;36:593–9.Google Scholar
Ambrosini, G, Sambol, EB, Carvajal, D,et al. Mouse double minute antagonist Nutlin-3a enhances chemotherapy-induced apoptosis in cancer cells with mutant p53 by activating E2F1. Oncogene. 2007;26:3473–81.Google Scholar
Binh, MB, Guillou, L, Hostein, I, et al. Dedifferentiated liposarcomas with divergent myosarcomatous differentiation developed in the internal trunk: a study of 27 cases and comparison to conventional dedifferentiated liposarcomas and leiomyosarcomas. Am J Surg Pathol. 2007;31:1557–66.Google Scholar
Binh, MB, Sastre-Garau, X, Guillou, L, et al. MDM2 and CDK4 immunostainings are useful adjuncts in diagnosing well-differentiated and dedifferentiated liposarcoma subtypes: a comparative analysis of 559 soft tissue neoplasms with genetic data. Am J Surg Pathol. 2005;29:1340–7.CrossRefGoogle ScholarPubMed
Coindre, JM, Hostein, I, Maire, G, et al. Inflammatory fibrous histiocytoma and dedifferentiated liposarcoma: histological review, genomic profile, and MDM2 and CDK4 status favour a single entity. J Pathol. 2004;203:822–30.Google Scholar
Dei Tos, AP. Liposarcomas: diagnostic pitfalls and new insights. Histopathology. 2014;64:3852.Google Scholar
Dei Tos, AP, Doglioni, C, Piccinin, S, et al. Molecular abnormalities of the p53 pathway in dedifferentiated liposarcoma. J Pathol. 1997;181:813.Google Scholar
Evans, HL. Liposarcoma: a study of 55 cases with a reassessment of its classification. Am J Surg Pathol. 1979;3:507–23.Google Scholar
Evans, HL. Atypical lipomatous tumor, its variants, and its combined forms: a study of 61 cases, with a minimum follow-up of 10 years. Am J Surg Pathol. 2007;31:114.CrossRefGoogle ScholarPubMed
Evans, HL, Khurana, KK, Kemp, BL, Ahayla, AG. Heterologous elements in the dedifferentiated component of dedifferentiated liposarcoma. Am J Surg Pathol. 1994;18:1150–7.Google Scholar
Fanburg-Smith, JC, Miettinen, M. Liposarcoma with meningothelial-like whorls: a study of 17 cases of a distinctive histological pattern associated with dedifferentiated liposarcoma. Histopathology. 1998;33:414–24.Google Scholar
Gronchi, A, Collini, P, Miceli, R, et al. Myogenic differentiation and histologic grading are major prognostic determinants in retroperitoneal liposarcoma. Am J Surg Pathol. 2015;39:383–93.Google Scholar
Gronchi, A, Lo Vullo, S, Fiore, M, et al. Aggressive surgical policies in a retrospectively reviewed single-institution case series of retroperitoneal soft tissue sarcoma patients. J Clin Oncol. 2009;27:2430.Google Scholar
Huang, HY, Brennan, MF, Singer, S, Antonescu, CR. Distant metastasis in retroperitoneal dedifferentiated liposarcoma is rare and rapidly fatal: a clinicopathological study with emphasis on the low-grade myxofibrosarcoma-like pattern as an early sign of dedifferentiation. Mod Pathol. 2005;18:976–84.Google Scholar
Le Guellec, S, Chibon, F, Ouali, M, et al. Are peripheral purely undifferentiated pleomorphic sarcomas with MDM2 amplification dedifferentiated liposarcomas? Am J Surg Pathol. 2014;38:293304.Google Scholar
Lucas, DR, Shukla, A, Thomas, DG, et al. Dedifferentiated liposarcoma with inflammatory myofibroblastic tumor-like features. Am J Surg Pathol. 2010;34:844–51.Google Scholar
Mariani, O, Brennetot, C, Coindre, JM, et al. JUN oncogene amplification and overexpression block adipocytic differentiation in highly aggressive sarcomas. Cancer Cell. 2007;11:361–74.Google Scholar
Mariño-Enríquez, A, Fletcher, CD, Dal Cin, P, Hornick, JL. Dedifferentiated liposarcoma with “homologous” lipoblastic (pleomorphic liposarcoma-like) differentiation: clinicopathologic and molecular analysis of a series suggesting revised diagnostic criteria. Am J Surg Pathol. 2010;34:1122–31.Google Scholar
Mertens, F, Fletcher, CDM, Dal Cin, P, et al. Cytogenetic analysis of 46 pleomorphic soft tissue sarcomas and correlation with morphologic and clinical features: a report of the CHAMP study group. CHromosomes And MorPhology. Genes Chromosomes Cancer. 1998;22:1625.Google Scholar
Mussi, C, Collini, P, Miceli, R, et al. The prognostic impact of dedifferentiation in retroperitoneal liposarcoma: a series of surgically treated patients at a single institution. Cancer. 2008;113:1657–65.Google Scholar
Nascimento, AG: Dedifferentiated liposarcoma. Sem Diagn Pathol. 2001;18:263–6.Google Scholar
Nascimento, AG, Kurtin, PJ, Guillou, L, Fletcher, CDM. Dedifferentiated liposarcoma. A report of nine cases with a peculiar neurallike whorling pattern associated with metaplastic bone formation. Am J Surg Pathol. 1998;22:945–55.Google Scholar
Pissaloux, D, Loarer, FL, Decouvelaere, AV, et al. MDM4 amplification in a case of de-differentiated liposarcoma and in-silico data supporting an oncogenic event alternative to MDM2 amplification in a subset of cases. Histopathology. 2017;71:1019–23.Google Scholar
Ricciotti, RW, Baraff, AJ, Jour, G, et al. High amplification levels of MDM2 and CDK4 correlate with poor outcome in patients with dedifferentiated liposarcoma: A cytogenomic microarray analysis of 47 cases. Cancer Genet. 2017;218219:6980.CrossRefGoogle ScholarPubMed
Saâda-Bouzid, E, Burel-Vandenbos, F, Ranchère-Vince, D, et al. Prognostic value of HMGA2, CDK4, and JUN amplification in well-differentiated and dedifferentiated liposarcomas. Mod Pathol. 2015;28:1404–14.Google Scholar
Singer, S, Socci, ND, Ambrosini, G, et al. Gene expression profiling of liposarcoma identifies distinct biological types/subtypes and potential therapeutic targets in well-differentiated and dedifferentiated liposarcoma. Cancer Res. 2007;67:6626–36.Google Scholar
Snyder, EL, Sandstrom, DJ, Law, K, et al. c-Jun amplification and overexpression are oncogenic in liposarcoma but not always sufficient to inhibit the adipocytic differentiation programme. J Pathol. 2009;218:292300.Google Scholar
Ware, PL, Snow, AN, Gvalani, M, Pettenati, MJ, Qasem, SA. MDM2 copy numbers in well-differentiated and dedifferentiated liposarcoma: characterizing progression to high-grade tumors. Am J Clin Pathol. 2014;141:334–41.Google Scholar
Weiss, SW, Rao, VK. Well-differentiated liposarcoma (atypical lipoma) of deep soft tissue of the extremities, retroperitoneum and miscellaneous sites. A follow-up study of 92 cases with analysis of the incidence of dedifferentiation. Am J Surg Pathol. 1992;16:1051–8.Google Scholar
Yamashita, K, Kohashi, K, Yamada, Y, et al. Osteogenic differentiation in dedifferentiated liposarcoma: a study of 36 cases in comparison to the cases without ossification. Histopathology. 2018;72:729–38.Google Scholar
Berner, K, Bjerkehagen, B, Bruland, ØS, Berner, A. Extraskeletal osteosarcoma in Norway, between 1975 and 2009, and a brief review of the literature. Anticancer Res. 2015;35:2129–40.Google Scholar
Conner, JR, Hornick, JL. SATB2 is a novel marker of osteoblastic differentiation in bone and soft tissue tumours. Histopathology. 2013;63:3649.CrossRefGoogle ScholarPubMed
de Silva, MV, Reid, R. Myositis ossificans and fibroosseous pseudotumor of digits: a clinicopathological review of 64 cases with emphasis on diagnostic pitfalls. Int J Surg Pathol. 2003;11:187–95.Google Scholar
Folpe, AL, Weiss, SW. Ossifying fibromyxoid tumor of soft parts: a clinicopathologic study of 70 cases with emphasis on atypical and malignant variants. Am J Surg Pathol. 2003;27:421–31.Google Scholar
Jones, M, Chebib, I, Deshpande, V, Nielsen, GP. Radiation-associated low-grade extraskeletal osteosarcoma of the neck following treatment for thyroid cancer. Int J Surg Pathol. 2015;23:384–7.Google Scholar
Lee, JS, Fetsch, JF, Wasdhal, DA, et al. A review of 40 patients with extraskeletal osteosarcoma. Cancer. 1995;1(76):2253–9.Google Scholar
Lidang Jensen, M, Schumacher, B, Myhre Jensen, O, Steen Nielsen, O, Keller, J. Extraskeletal osteosarcomas: a clinicopathologic study of 25 cases. Am J Surg Pathol. 1998;22:588–94.Google Scholar
Angervall, L, Kindblom, LG, Merck, C. Myxofibrosarcoma. A study of 30 cases. Acta Pathol Microbiol Scand A. 1977;85A:127–40.Google Scholar
Merck, C, Angervall, L, Kindblom, LG, et al. Myxofibrosarcoma. A malignant soft tissue tumor of fibroblastic-histiocytic origin. A clinicopathologic and prognostic study of 110 cases using multivariate analysis. Acta Pathol Microbiol Immunol Scand Suppl. 1983;282:140.Google Scholar
Weiss, SW, Enzinger, FM. Myxoid variant of malignant fibrous histiocytoma. Cancer. 1977;39:1672–85.Google Scholar
Willems, SM, Debiec-Rychter, M, Szuhai, K, Hogendoorn, PC, Sciot, R. Local recurrence of myxofibrosarcoma is associated with increase in tumour grade and cytogenetic aberrations, suggesting a multistep tumour progression model. Mod Pathol. 2006;19:407–16.Google Scholar
Oda, Y, Miyajima, K, Kawaguchi, K, et al. Pleomorphic leiomyosarcoma: clinicopathologic and immunohistochemical study with special emphasis on its distinction from ordinary leiomyosarcoma and malignant fibrous histiocytoma. Am J Surg Pathol. 2001;25:1030–8.Google Scholar
Dei Tos, AP, Maestro, R, Doglioni, C, et al. Ultraviolet-induced p53 mutations in atypical fibroxanthoma. Am J Pathol. 1994;145:1117.Google Scholar
Griewank, KG, Schilling, B, Murali, R, et al. TERT promoter mutations are frequent in atypical fibroxanthomas and pleomorphic dermal sarcomas. Mod Pathol. 2014;27:502–8.Google Scholar
Griewank, KG, Wiesner, T, Murali, R, et al. Atypical fibroxanthoma and pleomorphic dermal sarcoma harbor frequent NOTCH1/2 and FAT1 mutations and similar DNA copy number alteration profiles. Mod Pathol. 2018;31:418–28.Google Scholar
Gru, AA, Santa Cruz, DJ. Atypical fibroxanthoma: a selective review. Semin Diagn Pathol. 2013;30:412.Google Scholar
Kuwano, H, Hashimoto, H, Enjoji, M. Atypical fibroxanthoma distinguishable from spindle cell carcinoma in sarcoma-like skin lesions. A clinicopathologic and immunohistochemical study of 21 cases. Cancer. 1985;1(55):172–80.Google Scholar
Miller, K, Goodlad, JR, Brenn, T. Pleomorphic dermal sarcoma: adverse histologic features predict aggressive behavior and allow distinction from atypical fibroxanthoma. Am J Surg Pathol. 2012;36:1317–26.Google Scholar
Widemann, BC, Italiano, A. Biology and management of undifferentiated pleomorphic sarcoma, myxofibrosarcoma, and malignant peripheral nerve sheath tumors: state of the art and perspectives. J Clin Oncol. 2018;36:160–7.Google Scholar
Antonescu, CR, Zhang, L, Nielsen, GP, et al. Consistent t(1;10) with rearrangements of TGFBR3 and MGEA5 in both myxoinflammatory fibroblastic sarcoma and hemosiderotic fibrolipomatous tumor. Genes Chromosomes Cancer. 2011;50:757–64.Google Scholar
Boland, JM, Folpe, AL. Hemosiderotic fibrolipomatous tumor, pleomorphic hyalinizing angiectatic tumor, and myxoinflammatory fibroblastic sarcoma: related or not? Adv Anat Pathol. 2017;24:268–77.Google Scholar
Carter, JM, Sukov, WR, Montgomery, E, et al. TGFBR3 and MGEA5 rearrangements in pleomorphic hyalinizing angiectatic tumors and the spectrum of related neoplasms. Am J Surg Pathol. 2014;38:1182–992.Google Scholar
Folpe, AL, Weiss, SW. Pleomorphic hyalinizing angiectatic tumor: analysis of 41 cases supporting evolution from a distinctive precursor lesion. Am J Surg Pathol. 2004;28:1417–25.Google Scholar
Smith, ME, Fisher, C, Weiss, SW. Pleomorphic hyalinizing angiectatic tumor of soft parts. A low-grade neoplasm resembling neurilemoma. Am J Surg Pathol. 1996;20:21–9.Google Scholar

Save book to Kindle

To save this book to your Kindle, first ensure coreplatform@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about saving to your Kindle.

Note you can select to save to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be saved to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

Find out more about the Kindle Personal Document Service.

Available formats
×

Save book to Dropbox

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Dropbox.

Available formats
×

Save book to Google Drive

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Google Drive.

Available formats
×