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Reliability of basal plasma vasopressin concentrations in healthy male adults

Published online by Cambridge University Press:  07 December 2016

Daniel S. Quintana
NORMENT KG Jebsen Centre for Psychosis Research, Division of Mental Health and Addiction, Institute of Clinical Medicine, Oslo University Hospital, University of Oslo, Oslo, Norway
Lars T. Westlye
NORMENT KG Jebsen Centre for Psychosis Research, Division of Mental Health and Addiction, Institute of Clinical Medicine, Oslo University Hospital, University of Oslo, Oslo, Norway Department of Psychology, University of Oslo, Oslo, Norway
Knut T. Smerud
Smerud Medical Research International AS, Oslo, Norway
Ramy A. Mahmoud
OptiNose US Inc., Yardley, PA, USA
Per G. Djupesland
OptiNose AS, Oslo, Norway
Ole A. Andreassen*
NORMENT KG Jebsen Centre for Psychosis Research, Division of Mental Health and Addiction, Institute of Clinical Medicine, Oslo University Hospital, University of Oslo, Oslo, Norway
Ole A. Andreassen, NORMENT, KG Jebsen Centre for Psychosis Research, Building 49, Oslo University Hospital, Ullevål, Kirkeveien 166, PO Box 4956 Nydalen, N-0424 Oslo, Norway. Tel: +47 23 02 73 50 Fax: +47 23 02 73 33 E-mail:



The neuropeptides oxytocin (OT) and arginine vasopressin (AVP) play important and interrelated roles in modulating mammalian social behaviour. While the OT system has received considerable research attention for its potential to treat psychiatric symptoms, comparatively little is known about the role of the AVP system in human social behaviour. To better understand the intraindividual stability of basal AVP, the present study assessed the reproducibility of basal plasma AVP concentrations.


Basal plasma AVP was assessed at four sampling points separated by 8 days, on average, in 16 healthy adult males.


Only one out of six comparisons revealed strong evidence for reproducibility of basal AVP concentrations (visit 2 vs. visit 4: r=0.8, p<0.001; all other comparisons p>0.1). The concordance correlation coefficient [0.15, 95% CI (−0.55, 0.73)] also revealed poor overall reproducibility.


Poor reliability of basal AVP concentrations suggests future work covarying AVP with trait markers should proceed with careful consideration of intraindividual fluctuations.

Short Communications
© Scandinavian College of Neuropsychopharmacology 2016 

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