Hostname: page-component-6b989bf9dc-pkhfk Total loading time: 0 Render date: 2024-04-13T04:24:23.460Z Has data issue: false hasContentIssue false

Reliability of basal plasma vasopressin concentrations in healthy male adults

Published online by Cambridge University Press:  07 December 2016

Daniel S. Quintana
Affiliation:
NORMENT KG Jebsen Centre for Psychosis Research, Division of Mental Health and Addiction, Institute of Clinical Medicine, Oslo University Hospital, University of Oslo, Oslo, Norway
Lars T. Westlye
Affiliation:
NORMENT KG Jebsen Centre for Psychosis Research, Division of Mental Health and Addiction, Institute of Clinical Medicine, Oslo University Hospital, University of Oslo, Oslo, Norway Department of Psychology, University of Oslo, Oslo, Norway
Knut T. Smerud
Affiliation:
Smerud Medical Research International AS, Oslo, Norway
Ramy A. Mahmoud
Affiliation:
OptiNose US Inc., Yardley, PA, USA
Per G. Djupesland
Affiliation:
OptiNose AS, Oslo, Norway
Ole A. Andreassen*
Affiliation:
NORMENT KG Jebsen Centre for Psychosis Research, Division of Mental Health and Addiction, Institute of Clinical Medicine, Oslo University Hospital, University of Oslo, Oslo, Norway
*
Ole A. Andreassen, NORMENT, KG Jebsen Centre for Psychosis Research, Building 49, Oslo University Hospital, Ullevål, Kirkeveien 166, PO Box 4956 Nydalen, N-0424 Oslo, Norway. Tel: +47 23 02 73 50 Fax: +47 23 02 73 33 E-mail: o.a.andreassen@medisin.uio.no

Abstract

Objective

The neuropeptides oxytocin (OT) and arginine vasopressin (AVP) play important and interrelated roles in modulating mammalian social behaviour. While the OT system has received considerable research attention for its potential to treat psychiatric symptoms, comparatively little is known about the role of the AVP system in human social behaviour. To better understand the intraindividual stability of basal AVP, the present study assessed the reproducibility of basal plasma AVP concentrations.

Methods

Basal plasma AVP was assessed at four sampling points separated by 8 days, on average, in 16 healthy adult males.

Results

Only one out of six comparisons revealed strong evidence for reproducibility of basal AVP concentrations (visit 2 vs. visit 4: r=0.8, p<0.001; all other comparisons p>0.1). The concordance correlation coefficient [0.15, 95% CI (−0.55, 0.73)] also revealed poor overall reproducibility.

Conclusion

Poor reliability of basal AVP concentrations suggests future work covarying AVP with trait markers should proceed with careful consideration of intraindividual fluctuations.

Type
Short Communications
Copyright
© Scandinavian College of Neuropsychopharmacology 2016 

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

1. Neumann, ID, Landgraf, R. Balance of brain oxytocin and vasopressin: implications for anxiety, depression, and social behaviors. Trends Neurosci 2012;35:649659.Google Scholar
2. Acher, R, Chauvet, J, Chauvet, MT. Phylogeny of the neurohypophysial hormones. Eur J Biochem 1970;17:509513.CrossRefGoogle ScholarPubMed
3. Winslow, JT, Hastings, N, Carter, CS, Harbaugh, CR, Insel, TR. A role for central vasopressin in pair bonding in monogamous prairie voles. Nature 1993;365:545548.Google Scholar
4. Quintana, DS, Guastella, AJ, Westlye, LT, Andreassen, OA. The promise and pitfalls of intranasally administering psychopharmacological agents for the treatment of psychiatric disorders. Mol Psychiatry 2015;21:2938.CrossRefGoogle ScholarPubMed
5. Pietrowsky, R, Strüben, C, Mölle, M, Fehm, HL, Born, J. Brain potential changes after intranasal vs. intravenous administration of vasopressin: evidence for a direct nose-brain pathway for peptide effects in humans. Biol Psychiatry 1996;39:332340.CrossRefGoogle ScholarPubMed
6. Guastella, AJ, Kenyon, AR, Alvares, GA, Carson, DS, Hickie, IB. Intranasal arginine vasopressin enhances the encoding of happy and angry faces in humans. Biol Psychiatry 2010;67:12201222.Google Scholar
7. Uzefovsky, F, Shalev, I, Israel, S, Knafo, A, Ebstein, RP. Vasopressin selectively impairs emotion recognition in men. Psychoneuroendocrinology 2012;37:576580.Google Scholar
8. Boso, M, Emanuele, E, Politi, P et al. Reduced plasma apelin levels in patients with autistic spectrum disorder. Arch Med Res 2007;38:7074.Google Scholar
9. Miller, M, Bales, KL, Taylor, SL et al. Oxytocin and vasopressin in children and adolescents with autism spectrum disorders: sex differences and associations with symptoms. Autism Res 2013;6:91102.Google Scholar
10. Rubin, LH, Carter, CS, Bishop, JR et al. Reduced levels of vasopressin and reduced behavioral modulation of oxytocin in psychotic disorders. Schizophr Bull 2014;40:13741384.CrossRefGoogle ScholarPubMed
11. Jobst, A, Dehning, S, Ruf, S et al. Oxytocin and vasopressin levels are decreased in the plasma of male schizophrenia patients. Acta Neuropsych 2014;26:347355.Google Scholar
12. Gouin, J-P, Carter, CS, Pournajafi-Nazarloo, H et al. Plasma vasopressin and interpersonal functioning. Biol Psychol 2012;91:270274.Google Scholar
13. Carson, DS, Garner, JP, Hyde, SA et al. Arginine Vasopressin Is a Blood-Based Biomarker of Social Functioning in Children with Autism. PLoS One 2015;10:e0132224.CrossRefGoogle ScholarPubMed
14. Zhang, H-F, Dai, Y-C, Wu, J et al. Plasma oxytocin and arginine-vasopressin levels in children with autism spectrum disorder in China: associations with symptoms. Neurosci Bull 2016;32:423432.Google Scholar
15. Rubin, LH, Carter, CS, Bishop, JR et al. Peripheral vasopressin but not oxytocin relates to severity of acute psychosis in women with acutely-ill untreated first-episode psychosis. Schizophr Res 2013;146:138143.Google Scholar
16. Stachenfeld, NS, DiPietro, L, Kokoszka, CA, Silva, C, Keefe, DL, Nadel, ER. Physiological variability of fluid-regulation hormones in young women. J Appl Physiol 1999;86:10921096.Google Scholar
17. Weisman, O, Schneiderman, I, Zagoory-Sharon, O, Feldman, R. Salivary vasopressin increases following intranasal oxytocin administration. Peptides 2013;40:99103.Google Scholar
18. Lin, L. A concordance correlation coefficient to evaluate reproducibility. Biometrics 1989:255268.CrossRefGoogle ScholarPubMed
19. Quintana, DS, Westlye, LT, Rustan, ØG et al. Low dose oxytocin delivered intranasally with Breath Powered device affects social-cognitive behavior: a randomized 4-way crossover trial with nasal cavity dimension assessment. Transl Psychiatry 2015;5:19.CrossRefGoogle Scholar
20. Quintana, DS, Westlye, LT, Alnæs, D et al. Low dose intranasal oxytocin delivered with breath powered device dampens amygdala response to emotional stimuli: a peripheral effect-controlled within-subjects randomized dose-response fMRI trial. Psychoneuroendocrinology 2016;69:180188.Google Scholar
21. Wechsler, D. Weschsler Abbreviated Scale of Intelligence. San Antonio, TX: Psychological Corporation, 1999.Google Scholar
22. Lecrubier, Y, Sheehan, D, Weiller, E et al. The Mini International Neuropsychiatric Interview (MINI). A short diagnostic structured interview: reliability and validity according to the CIDI. Eur Psychiatry 1997;12:224231.Google Scholar
23. Spielberger, CD. Manual for the State-Trait Anxiety Inventory STAI (form Y) (‘self-evaluation questionnaire’), Palo Alto, CA: Consulting Psychologists Press, 1983.Google Scholar
24. JASP Team (2016). JASP (Version 0.8.0.0) [Computer software].Google Scholar
25. Cool, DR, DeBrosse, D. Extraction of oxytocin and arginine–vasopressin from serum and plasma for radioimmunoassay and surface-enhanced laser desorption–ionization time-of-flight mass spectrometry. J Chromatogr B 2003;792:375380.Google Scholar
26. Valstad, M, Alvares, GA, Andreassen, OA, Westlye, LT, Quintana, DS. The relationship between central and peripheral oxytocin concentrations: a systematic review and meta-analysis protocol. Syst Rev 2016;5:17.Google Scholar
27. Kagerbauer, S, Martin, J, Schuster, T, Blobner, M, Kochs, E, Landgraf, R. Plasma oxytocin and vasopressin do not predict neuropeptide concentrations in human cerebrospinal fluid. J Neuroendocrinol 2013;25:668673.Google Scholar
28. Leng, G, Ludwig, M. Intranasal oxytocin: myths and delusions. Biol Psychiatry 2016;79:243250.CrossRefGoogle ScholarPubMed
29. Thompson, R, George, K, Walton, J, Orr, S, Benson, J. Sex-specific influences of vasopressin on human social communication. Proc Natl Acad Sci 2006;103:78897894.Google Scholar
Supplementary material: File

Quintana Mendoza supplementary material

Supplementary Table and Figure

Download Quintana Mendoza supplementary material(File)
File 140.5 KB