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Gut–brain actions underlying comorbid anxiety and depression associated with inflammatory bowel disease

  • Áine Abautret-Daly (a1) (a2), Elaine Dempsey (a1) (a2), Adolfo Parra-Blanco (a3), Carlos Medina (a3) (a4) and Andrew Harkin (a1) (a2)...



Inflammatory bowel disease (IBD) is a chronic relapsing and remitting disorder characterised by inflammation of the gastrointestinal tract. There is a growing consensus that IBD is associated with anxiety- and depression-related symptoms. Psychological symptoms appear to be more prevalent during active disease states with no difference in prevalence between Crohn’s disease and ulcerative colitis. Behavioural disturbances including anxiety- and depression-like symptoms have also been observed in animal models of IBD.


The likely mechanisms underlying the association are discussed with particular reference to communication between the gut and brain. The close bidirectional relationship known as the gut–brain axis includes neural, hormonal and immune communication links. Evidence is provided for a number of interacting factors including activation of the inflammatory response system in the brain, the hypothalamic–pituitary–adrenal axis, and brain areas implicated in altered behaviours, changes in blood brain barrier integrity, and an emerging role for gut microbiota and response to probiotics in IBD.


The impact of psychological stress in models of IBD remains somewhat conflicted, however, it is weighted in favour of stress or early stressful life events as risk factors in the development of IBD, stress-induced exacerbation of inflammation and relapse.


It is recommended that patients with IBD be screened for psychological disturbance and treated accordingly as intervention can improve quality of life and may reduce relapse rates.

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Corresponding author

*Andrew Harkin, School of Pharmacy & Pharmaceutical Sciences and Trinity College Institute of Neuroscience, Trinity College Dublin, Dublin 2, Ireland. Tel: +353 1 896 8575; Fax: +353 1 896 2821; E-mail:


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Áine Abautret-Daly and Elaine Dempsey contributed equally to this work.



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Acta Neuropsychiatrica
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  • EISSN: 1601-5215
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