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Lack of association between BDNF Val66Met gene polymorphism and late-onset depression in a Chinese Han population

  • Jiayong You (a1), Yonggui Yuan (a1) (a2), Yanyan Shi (a1), Zhijun Zhang (a3), Xiangrong Zhang (a1) and Hailin Li (a1)...
<span class='bold'>Background:</span>

Val66Met polymorphism in the brain-derived neurotrophic factor (BDNF) gene has been suggested to be associated with major depressive disorder (MDD). There were a few reports of the relationship between the variant and late-onset depression (LOD) in Chinese Han population.

<span class='bold'>Objective:</span>

To investigate the relationship among BDNF Val66Met gene variants, BDNF plasma level and LOD.

<span class='bold'>Methods:</span>

Chinese Han patients with LOD (n = 99) and control subjects (n = 110) were assessed for BDNF Val66Met gene polymorphism. BDNF plasma level was tested only in LOD.

<span class='bold'>Results:</span>

There were no significant differences in genotypes and allele frequencies between cases and controls (p = 0.744 and p = 0.845, respectively). Plasma BDNF level also did not show significant differences in three genotypes in LOD (p = 0.860).

<span class='bold'>Conclusion:</span>

The Val66Met polymorphism in BDNF gene may not confer susceptibility to LOD in Chinese Han population.

Corresponding author
Yonggui Yuan, Department of Psychiatry, Nanjing Brain Hospital affiliated to Nanjing Medical University, Guangzhou Road 264#, Nanjing 210029, PR China. Tel: +86 25 83700011-6209; Fax: +86 25 8370 9025; E-mail:
Zhijun Zhang, Department of Neurology, Affiliated ZhongDa Hospital of Southeast University. DingJiaQiao Road 87#, Nanjing 210009, PR China. E-mail:
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Acta Neuropsychiatrica
  • ISSN: 0924-2708
  • EISSN: 1601-5215
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