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Adverse physical effects of alcohol misuse

  • G. A. Barclay, J. Barbour, S. Stewart, C. P. Day and E. Gilvarry...
Abstract

This article outlines the majority of the adverse physical effects that have been described secondary to the consumption of alcohol at levels above recommended sensible limits. These conditions are cited according to the organ system they belong to. Only brief descriptions are provided because of the vastness of this topic. The underlying pathophysiology of tolerance and withdrawal is touched upon as this is of relevance to the psychiatrist. Definitions of the terms used describing alcohol misuse, and sensible upper limits of alcohol consumption are also mentioned.

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References
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Abel, E. L. (2004) Paternal contribution to fetal alcohol syndrome. Addiction Biology, 9, 127133.
Abel, E. L. & Sokol, R.J. (1991) A revised conservative estimate of the incidence of FAS and its economic impact. Alcohol and Clinical Experience and Research, 5, 514524.
Alcohol Needs Assessment Research Project (2005) The 2004 National Alcohol Needs Assessment for England. UK Department of Health.
Anderson, P. & Baumberg, B. (2006) Alcohol in Europe: A Public Health Perspective. UK Institute of Alcohol Studies.
Ashley, M. J. & Rankin, J. G. (1980) Hazardous alcohol consumption and diseases of the circulatory system. Journal on the Study of Alcohol, 41, 10401070.
Becker, H. C. & Littleton, J. M. (1996) The alcohol withdrawal ‘kindling’ phenomenon. Clinical and experimental findings. Alcoholism: Clinical and Experimental Research, 20, 121A124A.
Brennan, F. N. & Lyttle, J. A. (1987) Alcohol and seizures: a review. Journal of the Royal Society of Medicine, 80, 571573.
Butterworth, R. F. (1995) Pathophysiology of alcoholic brain damage: synergistic effects of ethanol, thiamine deficiency and alcoholic liver disease. Metabolism and Brain Disease, 10, 18.
Charness, M. E. (1993) Brain lesions in alcoholics. Alcoholism: Clinical Experience and Research, 17, 211.
Charness, M. E., Safran, R. M. & Perides, G. (1994) Ethanol inhibits neural cell–cell adhesion. Journal of Biological Chemistry, 269, 93049309.
Chick, J. (1997) Alcohol and the brain. Current Opinion in Psychiatry, 10, 205210.
Corrao, G., Bagnardi, V., Zambon, A. et al (2004) A meta-analysis of alcohol consumption and the risk of 15 diseases. Preventive Medicine, 38, 613619.
Day, C. P., James, O. F., Butler, T. J. et al (1993) QT prolongation and sudden cardiac death in patients with alcoholic liver disease. Lancet, 341, 14231428.
Department of Health (1995) Sensible Drinking: Report of an Inter-Departmental Working Group. UK Department of Health.
Department of Health (2007) The Pregnancy Book 2007. UK Department of Health.
Djousse, L., Schatzkin, A., Chibnik, L. B. et al (2004) Alcohol consumption and the risk of bladder cancer in the Framingham Heart Study. Journal of the National Cancer Institute, 96, 13971400.
Elwood, J. M., Pearson, J. C. G., Skippen, D. H. et al (1984) Alcohol, smoking, social and occupational factors in the aetiology of cancer of the oral cavity, pharynx and larynx. International Journal of Cancer, 34, 603612.
Frajria, R. & Angeli, A. (1977) Alcohol-induced pseudo-Cushing's syndrome. Lancet, 1, 10501051.
Freudenheim, J. L., Ritz, J., Smith-Warner, S. A. et al (2005) Alcohol consumption and risk of lung cancer: a pooled analysis of cohort studies. American Journal of Clinical Nutrition, 82, 657667.
Fung, T., Hunter, D., Spiegelman, D. et al (2002) Intake of alcohol and alcoholic beverages and the risk of basal cell carcinoma of the skin. Cancer Epidemiology Biomarkers and Prevention, 11, 11191122.
Goodsell, D. (2006) The molecular perspective: alcohol. Oncologist, 11, 10451046.
Greenspon, A. J. & Schaal, S. F. (1983) The ‘holiday heart’: electro-physiologic studies of alcohol effects in alcoholics. Annals of Internal Medicine, 98, 135139.
Gunzerath, L., Faden, V., Zakhari, S. et al (2004) National Institute on Alcohol Abuse and Alcoholism report on moderate drinking. Alcoholism: Clinical and Experimental Research, 28, 829847.
Hamajima, N., Hirose, K., Tajima, K. et al (2002) Alcohol, tobacco and breast cancer: collaborative reanalysis of individual data from 53 epidemiological studies, including 58,515 women with breast cancer and 95,067 women without the disease. British Journal of Cancer, 87, 12341245.
Harper, C. G., Giles, M. & Finlay-Jones, R. (1986) Clinical signs in the Wernicke–Korsakoff complex: a retrospective analysis of 131 cases diagnosed at necropsy. Journal of Neurology, Neurosurgery, and Psychiatry, 49, 341345.
Heinz, A., Bauer, M., Kuhn, S. et al (1996) Long-term observation of the hypothalamic–pituitary–thyroid (HPT) axis in alcohol-dependent patients. Acta Psychiatrica Scandinavica, 93, 470476.
Higgins, E. M. & du Vivier, A. W. (1994) Cutaneous disease and alcohol misuse. British Medical Bulletin, 50, 8598.
Hodge, A. M., English, D. R., O'Dea, K. et al (2006) Alcohol intake, consumption pattern and beverage type, and the risk of Type II diabetes. Diabetic Medicine, 23, 690697.
Hoyme, H. E., May, P. A., Kalberg, W. O. et al (2005) A practical clinical approach to the diagnosis of fetal alcohol spectrum disorder: clarification of the 1996 Institute of Medicine criteria. Paediatrics, 115, 3947.
Jugdaohsingh, R., O'Connell, M. A., Sripanyakorn, S. et al (2006) Moderate alcohol consumption and increased bone mineral density: potential ethanol and non-ethanol mechanisms. Proceedings of the Nutrition Society, 65, 291310.
Jun-Ichi, I., Takahide, T. & Tetsuro, O. (2005) Acute abdominal distension secondary to urinary retention in a patient after alcohol withdrawal. Alcohol and Alcoholism, 40, 8687.
Keshavarzian, A., Iber, F. L., Dangleis, M. D. et al (1986) Intestinal-transit and lactose intolerance in chronic alcoholics. American Journal of Clinical Nutrition, 44, 7076.
Leon, D. A. & McCambridge, J. (2006) Liver cirrhosis mortality rates in Britain from 1950 to 2002: an analysis of routine data. Lancet, 367, 5256.
Liappas, I., Piperi, C., Malitas, P. N. et al (2006) Interrelationship of hepatic function, thyroid activity and mood status in alcohol-dependent individuals. International Journal of Experimental and Clinical Pathophysiology and Drug Research, 20, 293300.
Longnecker, M. P. & Enger, S. M. (1996) Epidemiologic data on alcoholic beverage consumption and risk of cancer. Clinica Chimica Acta, 246, 121141.
Mohamed, R., Forsey, P. R., Davies, M. K. et al (1996) Effect of liver transplantation on QT interval prolongation and autonomic dysfunction in end-stage liver disease. Hepatology, 23, 11281134.
Moskal, A., Norat, T., Ferrari, P. et al (2007) Alcohol intake and colorectal cancer risk: a dose–response meta-analysis of published cohort studies. International Journal of Cancer, 120, 664671.
Mukherjee, R. A. S., Hollins, S. & Turk, J. (2006) Fetal alcohol spectrum disorder: an overview. Journal of the Royal Society of Medicine, 99, 298302.
Nutt, D. (1999) Alcohol and the brain. Pharmacological insights for psychiatrists. British Journal of Psychiatry, 175, 114119.
Nutt, D., Adinoff, B. & Linnoila, M. (1988) Benzodiazepines in the treatment of alcoholism. In Advances in Alcoholism (vol. VII) (ed. Gallanter, M.) pp. 283313. Plenum.
O'Malley, S. S. & Krishnan-Sarin, S. (1998) Alcohol and neuropsychiatric disorders. Current Opinion in Psychiatry, 11, 253257.
Ozsoy, S., Esel, E., Izgi, H. B. et al (2006) Thyroid function in early and late alcohol withdrawal: relationship with aggression, family history, and onset age of alcoholism. Alcohol and Alcoholism, 41, 515521.
Patel, D. G. (1989) Effects of ethanol on carbohydrate metabolism and implications for the aging alcoholic. Alcohol Health and Research World (summer issue).
Pravdova, E. & Fickova, M. (2006) Alcohol intake modulates hormonal activity of adipose tissue. Endocrine Regulations, 40, 91104.
Prime Minister's Strategy Unit (2003) Strategy Unit Alcohol Harm Reduction Project: Interim Analytical Report. TSO (The Stationery Office).
Puddley, I. B. & Beilin-Lawrence, J. (2006) Alcohol is bad for blood pressure. Clinical and Experimental Pharmacology and Physiology, 33, 847852.
Royal College of Obstetricians and Gynaecologists (2006) Alcohol Consumption and the Outcomes of Pregnancy (RCOG Statement no. 5). RCOG.
Stewart, S. F. & Day, C. P. (2006) Alcoholic liver disease. In Zakim and Boyer's Hepatology (5th edn) (Boyer, T. D., Wright, T. L. & Manns, M. P.) pp. 579626. Elsevier.
Taylor, J. R. (1982) Alcohol and strokes. New England Journal of Medicine, 306, 1111.
Thuluvath, P. J. & Triger, D.R. (1989) Autonomic neuropathy and chronic liver disease. Quarterly Journal of Medicine, 72, 737747.
Vamvakas, S., Teschner, M., Bahner, U. et al (1998) Alcohol abuse: potential role in electrolyte disturbance and kidney diseases. Clinical Nephrology, 49, 205213.
Victor, M. & Adams, R. D. (1953) The effects of alcohol on the nervous system. Research Publications: Association for Research in Nervous and Mental Disease, 32, 526573.
Wakabayashi, I. & Kato, H. (2006) Alcohol abuse as a risk factor for ARDS. Japanese Journal of Alcohol Studies and Drug Dependence, 41, 400406.
Waldschmidt, T. J., Cook, R. T. & Kovacs, E. J. (2006) Alcohol and inflammation and immune responses. Summary of the 2005 Alcohol and Immunology Research Interest Group (AIRIG) meeting. Alcohol, 38, 121125.
World Health Organization (1992) The ICD–10 Classification of Mental and Behavioural Disorders: Clinical Descriptions and Diagnostic Guidelines. WHO.
World Health Organization (2004) Global Status Report on Alcohol. WHO.
Working Party of the Royal College of Psychiatrists and the Royal College of Physicians (2000) Drugs: Dilemmas and Choices. Gaskell.
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BJPsych Advances
  • ISSN: 1355-5146
  • EISSN: 1472-1481
  • URL: /core/journals/bjpsych-advances
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Adverse physical effects of alcohol misuse

  • G. A. Barclay, J. Barbour, S. Stewart, C. P. Day and E. Gilvarry...
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