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Economic implications of using Japanese Black sires carrying recessive genes associated with genetic defects

Published online by Cambridge University Press:  01 July 2008

M. Nishio ,
A. K. Kahi  and
H. Hirooka
M. Nishio*
Affiliation:
Laboratory of Animal Husbandry Resources, Graduate School of Agriculture, Kyoto University, 606-8502 Kyoto, Japan
A. K. Kahi
Affiliation:
Animal Breeding and Genetics Group, Department of Animal Sciences, Egerton University, P.O. Box 536, 20115 Egerton, Kenya
H. Hirooka
Affiliation:
Laboratory of Animal Husbandry Resources, Graduate School of Agriculture, Kyoto University, 606-8502 Kyoto, Japan
*
E-mail: mtnishio@kais.kyoto-u.ac.jp
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Abstract

The objective of this study was to calculate cumulative discounted expressions (CDE) for Japanese Black sires carrying a single defective allele in a herd by applying the gene-flow method to investigate the expression pattern of homozygous recessive genotype and to evaluate the monetary loss of using these sires. A single biallelic locus was considered with A representing the dominant allele and a representing the recessive allele. The gene-flow method was modified to consider the fitness of homozygous recessive genotype. Input parameters representing a typical situation in a Japanese Black cattle herd were used to calculate the CDE and the loss of using carrier sires. The effects of initial allele frequency and fitness on the CDE were determined for Aa and AA sires. The CDE of Aa sires were larger than those of AA sires under all initial allele frequencies and fitness. The difference in the CDE between using Aa and AA sires was largest when fitness was 0 (lethal recessive condition). The differences in the loss between Aa and AA sires were larger with increasing initial allele frequencies in lethal recessive condition. Applying the method used in this study to defects reported in Japanese Black cattle and with a population size of 628 000, the difference in the loss between using Aa and AA sires was US$48 575 800 and US$74 418 000 in the case of Band-3 and Claudin-16 deficiencies, respectively. The approach used in this study could be applied to other genetic defects in different breeds and species.

Keywords

gene-flowcumulative discounted expressionsrecessive genefitness
Type
Full Paper
Information
animal , Volume 2 , Issue 7 , July 2008 , pp. 1013 - 1018
Copyright
Copyright © The Animal Consortium 2008

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