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Northwest African distribution of the CD4/Alu microsatellite haplotypes

  • C. FLORES (a1), N. MACA-MEYER (a1), A. M. GONZÁLEZ (a1) and V. M. CABRERA (a1)
    • Published online: 26 July 2016

We have analysed a linked microsatellite/Alu polymorphism at the CD4 locus (CD4/Alu) in 666 chromosomes from samples of the Iberian Peninsula, Northwest Africa, and West sub-Saharan Africa. The Iberian Peninsula differs from other European populations by its higher levels of haplotype diversity (0.75), and weaker association between the microsatellite allele 90 and Alu(−) chromosomes. These results are explainable by a substantial gene flow from Northwest Africa. Significant geographic clines for the five major haplotypes suggest a south to north migration from sub-Saharan Africa into Northwest Africa. In spite of this, the consistent presence of haplotype 110(−) in this area is congruent with an ancient and autochthonous human presence in Northwest Africa.

Corresponding author
Correspondence: Dr Vicente M. Cabrera, Departamento de Genética, Facultad de Biología, Universidad de La Laguna, E-38271 La Laguna, Tenerife, Spain. Tel: +34 922 318350; Fax: +34 922 318311; E-mail:
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Annals of Human Genetics
  • ISSN: 0003-4800
  • EISSN: 1469-1809
  • URL: /core/journals/annals-of-human-genetics
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