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Psychotropic medication for problem behaviours in intellectual disability and autism spectrum disorder: the need for caution

Published online by Cambridge University Press:  15 May 2023

Marco O. Bertelli*
Affiliation:
Scientific director of the Research and Clinical Centre (Centro Ricerca E Ambulatori, CREA) of the San Sebastiano Foundation, Misericordia di Firenze, Florence, Italy.
*
Correspondence Marco O. Bertelli. Email: mbertelli@crea-sansebastiano.org

Summary

Many persons with intellectual developmental disorders and/or autism spectrum disorder presenting problem behaviours undergo pharmacotherapy without receiving an appropriate psychiatric assessment and diagnosis. Instead, prescription of psychotropic medication should have specific aims and involve interdisciplinary assessment, personalisation and patient and family participation. Current knowledge about pharmacological management of problem behaviours in this population is limited, necessitating extreme caution in clinical practice and more research into the complex interrelated factors that affect presentation, course and treatment response.

Type
Commentary
Copyright
Copyright © The Author(s), 2023. Published by Cambridge University Press on behalf of the Royal College of Psychiatrists

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Footnotes

Commentary on… Pharmacological management of psychopathology in people with intellectual disabilities and/or autism spectrum disorder. See this issue.

References

Bertelli, MO, Moss, S (2022) Diagnostic issues. In Textbook of Psychiatry for Intellectual Disability and Autism Spectrum Disorder (eds Bertelli, MO, Deb, S, Munir, K, et al): 107–22. Springer Nature.CrossRefGoogle Scholar
Deb, S, Kwok, H, Bertelli, M, et al (2009) International guide to prescribing psychotropic medication for the management of problem behaviours in adults with intellectual disabilities. World Psychiatry, 8: 181–6.CrossRefGoogle ScholarPubMed
Deb, S, Roy, M, Limbu, B (2022a) Pharmacological management of psychopathology in people with intellectual disabilities and/or autism spectrum disorder. BJPsych Advances, 29: this issue.Google Scholar
Deb, S, Bertelli, MO, Rossi, M (2022b) Psychopharmacology. In Textbook of Psychiatry for Intellectual Disability and Autism Spectrum Disorder (eds Bertelli, MO, Deb, S, Munir, K, et al): 247–9. Springer Nature.CrossRefGoogle Scholar
Hagopian, LP, Rooker, GW, Yenokyan, G (2018) Identifying predictive behavioral markers: a demonstration using automatically reinforced self-injurious behavior. Journal of Applied Behavior Analysis, 51: 443–65.CrossRefGoogle ScholarPubMed
Kaplan, G, McCracken, JT (2012) Psychopharmacology of autism spectrum disorders. Pediatric Clinics of North America, 59: 175–87.10.1016/j.pcl.2011.10.005CrossRefGoogle ScholarPubMed
Laverty, C, Oliver, C, Moss, J, et al (2020) Persistence and predictors of self-injurious behaviour in autism: a ten-year prospective cohort study. Molecular Autism, 11(1): 8.10.1186/s13229-019-0307-zCrossRefGoogle ScholarPubMed
Laverty, C, Agar, G, Sinclair-Burton, L, et al (2023) The 10-year trajectory of aggressive behaviours in autistic individuals. Journal of Intellectual Disabilities Research, 67: 295309.CrossRefGoogle ScholarPubMed
McCreary, B, Ayub, M (2015) Psychopharmacology and intellectual disability: the continuing dilemmas of “challenging behaviour”. Clinical Psychiatry, 1(2): 7.Google Scholar
Melville, CA, Johnson, PCD, Smiley, E, et al (2016) Problem behaviours and symptom dimensions of psychiatric disorders in adults with intellectual disabilities: an exploratory and confirmatory factor analysis. Research in Developmental Disabilities, 55: 113.CrossRefGoogle ScholarPubMed
National Institute for Health and Care Excellence (2012) Autism: Recognition, Referral, Diagnosis and Management of Adults on the Autism Spectrum (Clinical Guideline CG142). NICE.Google Scholar
Sandbank, M, Bottema-Beutel, K, Woynaroski, T (2021) Intervention recommendations for children with autism in light of a changing evidence base. JAMA Pediatrics, 175: 341–2.CrossRefGoogle ScholarPubMed
Smith, J, Baksh, RA, Hassiotis, A, et al (2022) Aggressive challenging behavior in adults with intellectual disability: an electronic register-based cohort study of clinical outcome and service use. European Psychiatry, 65(1): e74.CrossRefGoogle ScholarPubMed
Tyrer, P, Oliver-Africano, PC, Ahmed, Z, et al (2008) Risperidone, haloperidol, and placebo in the treatment of aggressive challenging behaviour in patients with intellectual disability: a randomised controlled trial. Lancet, 371: 5763.Google ScholarPubMed
Vitiello, B (2021) Editorial: targeting the core symptoms of autism spectrum disorder with mechanism-based medications. Journal of the American Academy of Child and Adolescent Psychiatry, 60: 816–7.10.1016/j.jaac.2020.11.006CrossRefGoogle ScholarPubMed
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