Skip to main content
    • Aa
    • Aa
  • Access
  • Cited by 24
  • Cited by
    This article has been cited by the following publications. This list is generated based on data provided by CrossRef.

    Koska, Juraj Ozias, Marlies K. Deer, James Kurtz, Julie Salbe, Arline D. Harman, S. Mitchell and Reaven, Peter D. 2016. A Human Model of Dietary Saturated Fatty Acid Induced Insulin Resistance. Metabolism,

    Deer, James Koska, Juraj Ozias, Marlies and Reaven, Peter 2015. Dietary models of insulin resistance. Metabolism, Vol. 64, Issue. 2, p. 163.

    Teng, Kim-Tiu Chang, Chee-Yan Kanthimathi, M.S. Tan, Alexander Tong Boon and Nesaretnam, Kalanithi 2015. Effects of amount and type of dietary fats on postprandial lipemia and thrombogenic markers in individuals with metabolic syndrome. Atherosclerosis, Vol. 242, Issue. 1, p. 281.

    Rebello, C. J. Greenway, F. L. and Finley, J. W. 2014. A review of the nutritional value of legumes and their effects on obesity and its related co-morbidities. Obesity Reviews, Vol. 15, Issue. 5, p. 392.

    Lozano, Aquiles Perez-Martinez, Pablo Marin, Carmen Tinahones, Francisco J. Delgado-Lista, Javier Cruz-Teno, Cristina Gomez-Luna, Purificacion Rodriguez-Cantalejo, Fernando Perez-Jimenez, Francisco and Lopez-Miranda, Jose 2013. An acute intake of a walnut-enriched meal improves postprandial adiponectin response in healthy young adults. Nutrition Research, Vol. 33, Issue. 12, p. 1012.

    Gupta, N and Jensen, M D 2012. Clinical effects of high-fat meals and weight gain due to high-fat feeding. International Journal of Obesity Supplements, Vol. 2, p. S51.

    Jackson, Kim G. Walden, Charlotte M. Murray, Peter Smith, Adrian M. Lovegrove, Julie A. Minihane, Anne M. and Williams, Christine M. 2012. A sequential two meal challenge reveals abnormalities in postprandial TAG but not glucose in men with increasing numbers of metabolic syndrome components. Atherosclerosis, Vol. 220, Issue. 1, p. 237.

    Ortega, Almudena Varela, Lourdes M. Bermudez, Beatriz Lopez, Sergio Abia, Rocio and Muriana, Francisco J. G. 2012. Dietary fatty acids linking postprandial metabolic response and chronic diseases. Food Funct., Vol. 3, Issue. 1, p. 22.

    Schwartz, Eric A. and Reaven, Peter D. 2012. Lipolysis of triglyceride-rich lipoproteins, vascular inflammation, and atherosclerosis. Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, Vol. 1821, Issue. 5, p. 858.

    Soares, M. J. Murhadi, L. L. Kurpad, A. V. Chan She Ping-Delfos, W. L. and Piers, L. S. 2012. Mechanistic roles for calcium and vitamin D in the regulation of body weight. Obesity Reviews, Vol. 13, Issue. 7, p. 592.

    Chan She Ping-Delfos, Wendy and Soares, Mario 2011. Diet induced thermogenesis, fat oxidation and food intake following sequential meals: Influence of calcium and vitamin D. Clinical Nutrition, Vol. 30, Issue. 3, p. 376.

    Teng, Kim-Tiu Nagapan, Gowri Cheng, Hwee Ming and Nesaretnam, Kalanithi 2011. Palm Olein and Olive Oil Cause a Higher Increase in Postprandial Lipemia Compared with Lard but Had No Effect on Plasma Glucose, Insulin and Adipocytokines. Lipids, Vol. 46, Issue. 4, p. 381.

    Gobert, Colleen P. Pipe, Elizabeth A. Capes, Sarah E. Darlington, Gerarda A. Lampe, Johanna W. and Duncan, Alison M. 2010. Soya protein does not affect glycaemic control in adults with type 2 diabetes. British Journal of Nutrition, Vol. 103, Issue. 03, p. 412.

    Jackson, Kim G. Clarke, Dave T. Murray, Peter Lovegrove, Julie A. O’Malley, Brendan Minihane, Anne M. and Williams, Christine M. 2010. Introduction to the DISRUPT postprandial database: subjects, studies and methodologies. Genes & Nutrition, Vol. 5, Issue. 1, p. 39.

    Papakonstantinou, E Triantafillidou, D Panagiotakos, D B Koutsovasilis, A Saliaris, M Manolis, A Melidonis, A and Zampelas, A 2010. A high-protein low-fat diet is more effective in improving blood pressure and triglycerides in calorie-restricted obese individuals with newly diagnosed type 2 diabetes. European Journal of Clinical Nutrition, Vol. 64, Issue. 6, p. 595.

    Papakonstantinou, E. Triantafillidou, D. Panagiotakos, D. B. Iraklianou, S. Berdanier, C. D. and Zampelas, A. 2010. A high protein low fat meal does not influence glucose and insulin responses in obese individuals with or without type 2 diabetes. Journal of Human Nutrition and Dietetics, Vol. 23, Issue. 2, p. 183.

    Soares, Mario J. Kuriyan, Rebecca and Kurpad, Anura V. 2010. Calcium and vitamin D modulate postprandial vascular function: A pilot dose–response study. Diabetes & Metabolic Syndrome: Clinical Research & Reviews, Vol. 4, Issue. 3, p. 128.

    Soares, Mario J. and She-Ping-Delfos, Wendy L. Chan 2010. Postprandial Energy Metabolism in the Regulation of Body Weight: Is there a Mechanistic Role for Dietary Calcium?. Nutrients, Vol. 2, Issue. 6, p. 586.

    Soares, M J and Chan She Ping-Delfos, W 2008. Second meal effects of dietary calcium and vitamin D. European Journal of Clinical Nutrition, Vol. 62, Issue. 7, p. 872.

    Berry, Sarah E. E. Woodward, Rebecca Yeoh, Christabelle Miller, George J. and Sanders, Thomas A. B. 2007. Effect of Interesterification of Palmitic Acid-rich Triacylglycerol on Postprandial Lipid and Factor VII Response. Lipids, Vol. 42, Issue. 4, p. 315.


Acute effects of meal fatty acid composition on insulin sensitivity in healthy post-menopausal women

  • M. D. Robertson (a1), K. G. Jackson (a2), B. A. Fielding (a1), C. M. Williams (a2) and K. N. Frayn (a1)
  • DOI:
  • Published online: 01 March 2007

Postprandial plasma insulin concentrations after a single high-fat meal may be modified by the presence of specific fatty acids although the effects of sequential meal ingestion are unknown. The aim of the present study was to examine the effects of altering the fatty acid composition in a single mixed fat–carbohydrate meal on glucose metabolism and insulin sensitivity of a second meal eaten 5 h later. Insulin sensitivity was assessed using a minimal model approach. Ten healthy post-menopausal women underwent four two-meal studies in random order. A high-fat breakfast (40 g fat) where the fatty acid composition was predominantly saturated fatty acids (SFA), n-6 polyunsaturated fatty acids (PUFA), long-chain n-3 PUFA or monounsaturated fatty acids (MUFA) was followed 5 h later by a low-fat, high-carbohydrate lunch (5·7 g fat), which was identical in all four studies. The plasma insulin response was significantly higher following the SFA meal than the other meals after both breakfast and lunch (P<0·006) although there was no effect of breakfast fatty acid composition on plasma glucose concentrations. Postprandial insulin sensitivity (SI(Oral)) was assessed for 180 min after each meal. SI(Oral) was significantly lower after lunch than after breakfast for all four test meals (P=0·019) following the same rank order (SFA < n-6 PUFA < n-3 PUFA < MUFA) for each meal. The present study demonstrates that a single meal rich in SFA reduces postprandial insulin sensitivity with ‘carry-over’ effects for the next meal.

    • Send article to Kindle

      To send this article to your Kindle, first ensure is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about sending to your Kindle.

      Note you can select to send to either the or variations. ‘’ emails are free but can only be sent to your device when it is connected to wi-fi. ‘’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

      Find out more about the Kindle Personal Document Service.

      Acute effects of meal fatty acid composition on insulin sensitivity in healthy post-menopausal women
      Your Kindle email address
      Available formats
      Send article to Dropbox

      To send this article to your Dropbox account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your Dropbox account. Find out more about sending content to Dropbox.

      Acute effects of meal fatty acid composition on insulin sensitivity in healthy post-menopausal women
      Available formats
      Send article to Google Drive

      To send this article to your Google Drive account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your Google Drive account. Find out more about sending content to Google Drive.

      Acute effects of meal fatty acid composition on insulin sensitivity in healthy post-menopausal women
      Available formats
Corresponding author
*Corresponding author: Dr M. D. Robertson, fax +44 1865 224652, email
Linked references
Hide All

This list contains references from the content that can be linked to their source. For a full set of references and notes please see the PDF or HTML where available.

JD Best , SE Kahn , M Ader , RM Watanabe , TC Ni & RN Bergman (1996) Role of glucose effectiveness in the determination of glucose tolerance. Diabetes Care 19, 10181030.

G Boden , B Lebed , M Schatz , C Homko & S Lemieux (2001) Effects of acute changes of plasma free fatty acids on intramyocellular fat content and insulin resistance in healthy subjects. Diabetes 50, 16121617.

A Caumo , RN Bergman & C Cobelli (2000) Insulin sensitivity from meal tolerance tests in normal subjects: a minimal model index. Journal of Clinical Endocrinology and Metabolism 85, 43964402.

SW Coppack , RD Evans , RM Fisher , KN Frayn , GF Gibbons , SM Humphreys , MJ Kirk , JL Potts & TDR Hockaday (1992) Adipose tissue metabolism in obesity: lipase action in vivo before and after a mixed meal. Metabolism 41, 264272.

N Ercan , FQ Nuttall & MC Gannon (1994) Effect of added fat on the plasma glucose and insulin response to ingested potato given in various combinations as two meals in normal individuals. Diabetes Care 17, 14531459.

DL Frape , NR Williams , J Rajput Williams , BW Maitland , AJ Scriven , CR Palmer & RJ Fletcher (1998) Effect of breakfast fat content on glucose tolerance and risk factors of atherosclerosis and thrombosis. British Journal of Nutrition 80, 323331.

MC Gannon , FQ Nuttall , SA Westphal & ER Seaquist (1993) The effect of fat and carbohydrate on plasma glucose, insulin, c-peptide, and triglycerides in normal male subjects. Journal of the American College of Nutrition 12, 3641.

GM Reaven (1988) Role of insulin resistance in human disease. Diabetes 31, 670673.

DT Stein , BE Stevenson , MW Chester , M Basit , M Daniels , SD Turley & JD McGarry (1997) The insulinotropic potency of fatty acids is influenced profoundly by their chain length and degree of saturation. Journal of Clinical Investigation 100, 398403.

IM Welch , C Bruce , SE Hill & NW Read (1987) Duodenal and ileal lipid suppresses postprandial blood glucose and insulin responses in man: possible implications for the dietary management of diabetes mellitus. Clinical Science 72, 209216.

Recommend this journal

Email your librarian or administrator to recommend adding this journal to your organisation's collection.

British Journal of Nutrition
  • ISSN: 0007-1145
  • EISSN: 1475-2662
  • URL: /core/journals/british-journal-of-nutrition
Please enter your name
Please enter a valid email address
Who would you like to send this to? *