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An α-lactalbumin-enriched and symbiotic-supplemented v. a standard infant formula: a multicentre, double-blind, randomised trial

  • Jean-Christophe Rozé (a1) (a2) (a3), Sébastien Barbarot (a4), Marie-José Butel (a5), Nathalie Kapel (a5), Anne-Judith Waligora-Dupriet (a5), Inès De Montgolfier (a6), Magali Leblanc (a7), Nathalie Godon (a1), Pascale Soulaines (a8), Dominique Darmaun (a3), Montserrat Rivero (a9) and Christophe Dupont (a8)
  • DOI: http://dx.doi.org/10.1017/S000711451100479X
  • Published online: 14 November 2011
Abstract

The aim of the present study was to evaluate the safety, tolerance and preventive effect on atopic dermatitis of an experimental α-lactalbumin-enriched and symbiotic-supplemented infant formula. A total of ninety-seven non-breastfed term neonates were enrolled into a double-blind, multicentre, randomised controlled trial in which they received experimental (n 48) or standard formula (n 49) for 6 months. The primary outcome was weight at 6 months of age. Secondary outcomes were gastrointestinal tolerance and manifestation of atopic dermatitis. Faecal secretory IgA (SIgA) concentration and microbiota composition of forty-three infants were analysed at 1 and 6 months. Growth was similar in both groups. At 1 month, compared to those in the control group, infants in the experimental group exhibited less crying or agitation, and more quiet behaviour (P = 0·03). At 6 months, atopic dermatitis was less frequently observed in the experimental group (P < 0·05). Decrease of faecal SIgA concentration between 1 and 6 months was mainly observed in the control group. This decrease was significantly associated with atopic dermatitis (P < 0·014) and negatively correlated to the level of colonisation by bifidobacteria (P < 0·005). In conclusion, compared to the control formula, the experimental formula guaranteed a similar growth, was better tolerated at 1 month and had a protective effect against the development of atopic dermatitis.

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Corresponding author
*Corresponding author: Professor J.-C. Rozé, fax +33 240 083 556, email jcroze@chu-nantes.fr
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British Journal of Nutrition
  • ISSN: 0007-1145
  • EISSN: 1475-2662
  • URL: /core/journals/british-journal-of-nutrition
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