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Anticarcinogenic effect of probiotic fermented milk and chlorophyllin on aflatoxin-B1-induced liver carcinogenesis in rats

  • M. Kumar (a1), V. Verma (a2), R. Nagpal (a3), A. Kumar (a4), P. V. Behare (a5), B. Singh (a6) and P. K. Aggarwal (a1)
  • DOI: http://dx.doi.org/10.1017/S0007114511003953
  • Published online: 05 August 2011
Abstract

The present investigation was carried out to evaluate the hepatoprotective effect of probiotic fermented milk (FM) containing Lactobacillus rhamnosus GG and Lactobacillus casei strain Shirota, alone as well as in combination with chlorophyllin (CHL) as an antioxidant agent in male Wistar rats administered aflatoxin-B1 (AFB1). AFB1 was injected intraperitoneally at the rate of 450 μg/kg body weight per animal twice a week for 6 weeks, maintaining an equal time interval between the two consecutive AFB1 administrations. A total of 125 male Wistar rats were randomly allocated to five groups, each group having twenty-five animals. Group I was offered FM containing L. rhamnosus GG and L. casei strain Shirota. Group II was administered AFB1 and served as the control group; group III was administered FM-AFB1, in which besides administering AFB1, FM was also offered. Group IV was offered CHL and AFB1, and group V was offered both FM and CHL along with AFB1. The rats were euthanised at the 15th and 25th week of the experiment and examined for the biochemical and hepatopathological profile. A significant reduction in thiobarbituric acid-reactive substances (TBARS) was observed in the FM–CHL–AFB1 group compared with the AFB1 control group. FM alone or in combination with CHL was found to show a significant (P < 0·05) hepatoprotective effect by lowering the levels of TBARS and by enhancing the activities of antioxidant enzymes such as glutathione peroxidase, superoxide dismutase, catalase and glutathione-S-transferase, indicating that probiotic FM alone or in combination with CHL possesses a potent protective effect against AFB1-induced hepatic damage.

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*Corresponding author: M. Kumar, email manoj15micro@yahoo.co.in
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2DL Eaton , HS Ramsdell & GE Neal (1994) Biotransformation of aflatoxins. In The Toxicology of Aflatoxins: Human Health, Veterinary and Agricultural Significance, pp. 4571 [DL Eaton and J Groopman , editors]. New York: Academic Press.

5M Kumar , A Kumar , R Nagpal , (2010) Cancer-preventing attributes of probiotics: an update. Int J Food Sci Nutr 61, 473496.

6C Haskard , C Binnion & J Ahokas (2000) Factors affecting the sequestration of aflatoxin by Lactobacillus rhamnosus strain GG. Chem Biol Interact 128, 3949.

7J Singh , A Rivenson , M Tomita , (1997) Bifidobacterium longum, a lactic acid-producing intestinal bacterium inhibits colon cancer and modulates the intermediate biomarkers of colon carcinogenesis. Carcinogenesis 18, 833841.

9JJ Rafter (1995) The role of lactic acid bacteria in colon cancer prevention. Scand J Gastroenterol 30, 497502.

10H Annuk , J Shchepetova , T Kullisaar , (2003) Characterization of intestinal lactobacilli as putative probiotic candidates. J Appl Microbiol 94, 403412.

13E Tavan , C Cayuela , JM Antoine , (2002) Effects of dairy products on heterocyclic aromatic amine-induced rat colon carcinogenesis. Carcinogenesis 23, 477483.

14IR Rowland , CJ Rumney , JT Coutts , (1998) Effect of Bifidobacterium longum and inulin on gut bacterial metabolism and carcinogen-induced aberrant crypt foci in rats. Carcinogenesis 19, 281285.

15C Iyer , A Kosters , G Sethi , (2008) Probiotic Lactobacillus reuteri promotes TNF-induced apoptosis in human myeloid leukemia-derived cells by modulation of NF-κB and MAPK signalling. Cellular Microbiol 10, 14421452.

16R Dashwood , T Negishi , H Hayatsu , (1998) Chemopreventive properties of chlorophylls towards aflatoxin B1: a review of antimutagenicity and anticarcinogenicity data in rainbow trout. Mutat Res 399, 245253.

17D Sharma , SS Kumar & KB Sainis (2007) Antiapoptotic and immunomodulatory effects of chlorophyllin. Mol Immunol. 44, 347359.

18V Breinholt , M Schimerlik , R Dashwood , (1995) Mechanisms of chlorophyllin anticarcinogenesis against aflatoxin B1: complex formation with the carcinogen. Chem Res Toxicol 8, 506514.

19V Breinholt , D Arbogast , P Leveland , (1999) Chlorophyllin chemoprevention in trout initiated by aflatoxin B1. Toxicol Appl Pharmacol 158, 141151.

20BR Goldin , LJ Gualtieri & RP Moore (1996) The effect of Lactobacillus GG on the initiation and promotion of DMH-induced intestinal tumors in the rat. Nutr Cancer 25, 197204.

21M Uchiyama & M Mahira (1978) Determination of malonaldehyde precursor in tissue by thiobarbituric acid test. Anal Biochem 86, 271278.

22GL Ellman (1959) Tissue sulphydryl groups. Arch Biochem Biophys 82, 7077.

23AL Tapple (1978) Glutathione peroxidase and hydroperoxidase. Methods Enzymol 52, 506513.

26H Aebi (1984) Catalase in vitro. Methods Enzymol 105, 121126.

28HS Kim , DB Hausman , MM Comton , (2000) Induction of apoptosis by all-trans-retinoic acid and C2-ceramide treatment in rat stromal-vascular cultures. Biochem Biophys Res Commun 270, 7680.

30MA Trush & TW Kensler (1991) An overview of the relationship between oxidative stress and chemical carcinogenesis. Free Radic Biol Med 10, 201209.

31 AK Chaudhary , M Nokubo , LJ Marnett , (1994) Analysis of the malondialdehyde-2′-deoxyguanosine adduct in rat liver DNA by gas chromatography/electron capture negative chemical ionization mass spectrometry. Biol Mass Spectrom 23, 457464.

32H Yadav , S Jain & P Sinha (2009) Antidiabetic effect of probiotic dahi containing Lactobacillus acidophilus and Lactobacillus casei in high fructose fed rats. Nutrition 23, 6268.

33G Moorthy , MR Murali & SN Devaraj (2007) Protective role of lactobacilli in Shigella dysenteriae 1-induced diarrhea in rats. Nutrition 23, 424433.

34JP Kamat , KK Boloor & TP Devasagayam (2000) Chlorophyllin as an effective antioxidant against membrane damage in vitro and ex vivo. Biochim Biophys Acta 1487, 113127.

35JD Hayes & LI McLellan (1999) Glutathione and glutathione-dependent enzymes represent a co-ordinately regulated defence against oxidative stress. Free Radic Res 31, 273300.

36ME Murphy , H Scholich & H Sies (1992) Protection by glutathione and other thiol compounds against the loss of protein thiols and tocopherol homologs during microsomal lipid peroxidation. Eur J Biochem 210, 139146.

38HM Shen , CY Shi , HP Lea , (1994) Aflatoxin B1-induced lipid peroxidation in rat liver. Toxicol Appl Pharmacol 127, 145150.

39H Abdelali , P Cassand , V Soussotte , (1995) Effect of dairy products on initiation of precursor lesions of colon cancer in rats. Nutr Cancer 24, 121123.

40I El-Gibaly , AM Meki & SK Abdel-Ghaffar (2003) Novel B-melatonin loaded chitosan macrocapsules: in vitro characterization and antiapoptosis efficacy for aflatoxin B1 induced apoptosis in rat liver. Int J Pharmacol 260, 2254.

41C Jubert , J Mata , G Bench , (2009) Effects of chlorophyll and chlorophyllin on low-dose aflatoxin B(1) pharmacokinetics in human volunteers. Cancer Prev Res (Phila) 2, 10151022.

42Y Zhang , L Guan , X Wang , (2008) Protection of chlorophyllin against oxidative damage by inducing HO-1 and NQO1 expression mediated by PI3K/Akt and Nrf2. Free Radic Res 42, 362371.

43E Kot & A Bezkorovainy (2000) The binding of H2O2-generated Fe (III) to Bifidobacterium thermophilum depends on the method of its production. J Food Sci 65, 10281032.

45L Gate , J Paul , BA Nguyen , (1999) Oxidative stress induced in pathologies: the role of antioxidants. Biomed Pharmacother 53, 169180.

46AH Abou Ghalia & IM Fouad (2000) Glutathione and its metabolizing enzymes in patients with different benign and malignant diseases. Clin Biochem 33, 657662.

48S Gratz , M Taubel , RO Juvonen , (2007) Lactobacillus rhamnosus strain GG modulates intestinal absorption, fecal excretion, and toxicity of aflatoxin b1 in rats. Appl Environ Microbiol 72, 73987400.

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