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Calcium excretion, apparent calcium absorption and calcium balance in young and elderly subjects: influence of protein intake

Published online by Cambridge University Press:  09 March 2007

Daphne L. E. Pannemans ,
Gertjan Schaafsma  and
Klaas R. Westerterp
Daphne L. E. Pannemans
Affiliation:
Department of Human Biology, University of Limburg, PO Box 616, 6200 MD Maastricht, The Netherlands
Gertjan Schaafsma
Affiliation:
Department of Human Nutrition, TNO Toxicology and Nutrition Institute, PO Box 360, 3700 MD Zeist, The Netherlands
Klaas R. Westerterp
Affiliation:
Department of Human Biology, University of Limburg, PO Box 616, 6200 MD Maastricht, The Netherlands
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Abstract

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The present study was conducted to investigate the effect of dietary protein on urinary Ca excretion, apparent Ca absorption and Ca balance in young and elderly subjects. Young adults (n 29) and elderly persons (n 26) consumed diets containing 12% (diet A) and 21% (diet B) of total energy as protein for 3 weeks according to a randomized crossover design. Results showed no differences between the two age groups with respect to the interaction between protein intake and Ca excretion (both in urine and in faeces), apparent Ca absorption and Ca balance. Therefore analyses were done for both age groups separately and also for the whole group. In elderly persons and in the whole group the Ca excretion in faeces (as a percentage of Ca intake) was lower during the higher protein intake (elderly: diet A, 106 (SEM 7)% diet B, 86 (SEM 7) % P = 0·018; whole group: diet A, 99 (SEM 4) % diet B, 84 (SEM 4) % P = 0·003). In young adults faecal Ca excretion tended to be lower when they consumed diet B (diet A: 94 (SEM 5)% diet B: 83 (SEM 6)% P = 0·093). Relative urinary Ca excretion was greater during the higher protein intake in young adults and in the whole group while relative urinary Ca excretion was not different in the elderly (diet A: 15 (SEM 1) %, 14 (SEM 1) %, 15 (SEM 1) % diet B: 16 (SEM 1) %, 16 (SEM 1) % 17 (SEM 2) % for the whole group, the young and elderly subjects respectively, P = 0·019; P = 0·016; P = 0·243).The resulting Ca balance was not influenced by the amount of protein in the diet in young adults. Values for the elderly and for the whole group showed that the Ca balance during diet A was significantly more negative compared with Ca balance during diet B, despite the higher urinary Ca excretion during diet B. It can be concluded that increasing the protein intake from 12 to 21% of total energy ntake had no negative effect on Ca balance.

Keywords

CalciumProtein intakeElderly
Type
Human and Clinical Nutrition
Information
British Journal of Nutrition , Volume 77 , Issue 5 , May 1997 , pp. 721 - 729
Copyright
Copyright © The Nutrition Society 1997

References

REFERENCES

Allen, L. H., Oddoye, E. A. & Margen, S. (1979). Protein-induced hypercalciuria: a longer term study. American Journal of Clinical Nutrition 32, 741–749.CrossRefGoogle ScholarPubMed
Anand, C. R. & Linkswiler, H. M. (1974). Effect of protein intake on calcium balance of young men given 500 mg calcium daily. Journal of Nutrition 104, 695–700.CrossRefGoogle ScholarPubMed
Bell, A. A., Engelman, D. T., Sie, T.-L. & Draper, H. H. (1975). Effect of high protein intake on calcium metabolism in the rat. Journal of Nutrition 105, 475–483.CrossRefGoogle Scholar
Chu, J. Y., Margen, S. & Costa, F. M. (1975). Studies in calcium metabolism. II. Effects of low calcium and variable protein intake on human calcium metabolism. American Journal of Clinical Nutrition 28, 1028–1035.CrossRefGoogle ScholarPubMed
Grindler, E. M. & King, J. D. (1972). Rapid colorimetric determination of calcium in biological fluids with methylthymol blue. American Journal of Clinical Pathology 58, 376–382.CrossRefGoogle Scholar
Heany, R. P. (1986). Calcium intake, bone health and aging. In Nutrition, Aging and Health, pp. 165–186 [Young, E. A. editor]. New York: Alan R. Liss.Google Scholar
Hegsted, M. & Linkswiler, H. M. (1981). Long-term effects of level of protein intake on calcium metabolism in young adult women. Journal of Nutrition 111, 244–251.CrossRefGoogle ScholarPubMed
Hegsted, M., Schuette, S. A., Zemel, M. B. & Linkswiler, H. M. (1981). Urinary calcium and calcium balance in young men as affected by level of protein and phosphorus intake. Journal of Nutrition 111, 553–562.CrossRefGoogle ScholarPubMed
Henry, R. J., Cannon, D. C. & Winkelman, J. W. (1974). Clinical Chemistry, Principles and Techniques 2nd ed. New York: Harper and Row.Google Scholar
Johnson, N. E., Alcantara, E. N. & Linkswiler, H. (1970). Effect of level of protein intake on urinary and faecal calcium and calcium retention of young adult males. Journal of Nutrition 100, 1425–1430.CrossRefGoogle ScholarPubMed
Kim, Y. & Linkswiler, H. M. (1979). Effect of level of protein intake on calcium metabolism and parathyroid and renal function in adult human male. Journal of Nutrition 109, 1399–1404.CrossRefGoogle ScholarPubMed
Lutz, J. & Linkswiler, H. M. (1981). Calcium metabolism in post menopausal women consuming two levels of dietary protein. American Journal of Clinical Nutrition 34, 2178–2186.CrossRefGoogle Scholar
Margen, S., Chu, J. Y., Kaufman, N. A. & Calloway, D. H. (1974). Studies in calcium metabolism. I. The calciuretic effect of dietary protein. American Journal of Clinical Nutrition 27, 584–589.CrossRefGoogle ScholarPubMed
Pannemans, D. L. E., Halliday, D. & Westerterp, K. R. (1995). Whole-body protein turnover in elderly men and women: responses to two levels of protein intake. American Journal of Clinical Nutrition 61, 33–38.CrossRefGoogle Scholar
Pannemans, D. L. E. & Westerterp, K. R. (1993). Estimation of energy intake to feed subjects at energy balance as verified with doubly labelled water: a study in the elderly. European Journal of Clinical Nutrition 47, 490–496.Google Scholar
Schuette, S. A. & Linkswiler, H. M. (1982). Effects on Ca and P metabolism in humans by adding meat, meat plus milk, or purified protein plus Ca and P to a low protein diet. Journal of Nutrition 112, 338–349.CrossRefGoogle ScholarPubMed
Schuette, S. A., Zemel, M. B. & Linkswiler, H. M. (1980). Studies on the mechanism of protein induced hypercalciuria in older men and women. Journal of Nutrition 110, 305–315.CrossRefGoogle ScholarPubMed
Short, C. & Flynn, A. (1990). Sodium—calcium inter-relationships with specific reference to osteoporosis. Nutrition Research Reviews 3, 101–115.CrossRefGoogle Scholar
Spencer, H., Kramer, L., DeBartolo, M., Noms, C. & Osis, D. (1983). Further studies of the effect of a high protein diet as meat on calcium metabolism. American Journal of Clinical Nutrition 37, 924–929.CrossRefGoogle ScholarPubMed
Spencer, N., Kramer, L. & Osis, D. (1988). Do protein and phosphorus cause calcium loss? Journal of Nutrition 118, 657–660.CrossRefGoogle ScholarPubMed
Spencer, H., Kramer, L., Osis, D. & Norris, C. (1978a). Effect of phosphorus on the absorption of calcium balance in man. Journal of Nutrition 108, 447–457.CrossRefGoogle ScholarPubMed
Spencer, H., Kramer, L., Osis, D. & Norris, C. (1978b). Effect of high protein (meat) intake on calcium metabolism in man. American Journal of Clinical Nutrition 31, 2167–2180.CrossRefGoogle ScholarPubMed
Walker, R. M. & Linkswiler, H. M. (1972). Calcium retention in the adult human male as affected by protein intake. Journal of Nutrition 102, 1297–1302.CrossRefGoogle ScholarPubMed
Zemel, M. B., Schuette, S. A., Hegsted, M. & Linkswiler, H. M. (1981). Role of the sulphur-containing amino acids in protein-induced hypercalciuria in men. Journal of Nutrition 111, 545–552.CrossRefGoogle Scholar