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Cardiovascular β-adrenoceptor sensitivity of undernourished subjects

Published online by Cambridge University Press:  09 March 2007

M. Prem Jayarajan  and
P. S. Shetty
M. Prem Jayarajan
Affiliation:
Department of Physiology, Nutrition Research Centre (ICMR), St John's Medical College, Bangalore 560 034, India
P. S. Shetty
Affiliation:
Department of Physiology, Nutrition Research Centre (ICMR), St John's Medical College, Bangalore 560 034, India
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Abstract

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1. Eleven normal-weight male subjects (weight/height2 (W/H2) 19.0-225) from a good socio-economic background and on ad lib. food intake, and eight undernourished male labourers (W/H2 16.4–18.6) on low energy intakes, were studied.

2. Comparison of cardiovascular responses to increasing single doses of the β-agonist, isoproterenol, showed a significantly greater positive chronotropic dose response in the undernourished subjects.

3. Cardiovascular responses to head-up tilt were similar in both the normal-weight and undernourished subjects.

4. Undernourished individuals may show an increase in β-adrenoceptor sensitivity which may be akin to a denervation type of supersensitivity as a result of a nutrition-related reduction in sympathetic activity.

Type
Clinical and Human Nutrition papers
Information
British Journal of Nutrition , Volume 58 , Issue 1 , July 1987 , pp. 5 - 11
Copyright
Copyright © The Nutrition Society 1987

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