Skip to main content
×
Home
    • Aa
    • Aa

The cardiovascular, metabolic and hormonal changes accompanying acute starvation in men and women

  • J. Webber (a1) and I. A. Macdonald (a1)
Abstract

The effect of fasting for 12, 36 and 72 h was studied in twenty-nine healthy subjects (seventeen women and twelve men). Measurements were made of cardiovascular variables, metabolic rate, respiratory exchange ratio, plasma metabolites, insulin, thyroid hormones and catecholamines. During starvation there were no significant changes in blood pressure, whilst heart rate (beatslmin) increased at 36 h and remained elevated after 72 h (12 h 625 (SE 1.8), 36 h 68.0 (SE 1.9), 72 h 69 2 (SE 1.8); P< 0.001). Forearm blood flow (FBF), increased progressively from 3.32 (SE 0.20) to 6.21 (SE 0.46) m1/100 ml per min (P < 0.001). Resting metabolic rate (kJ/min) was significantly increased after 36 h of starvation (12 h 4 60 (SE 0.14), 36 h 4 88 (SE 0.13), P < 0.001), but was not significantly different from the 12 h value after 72 h (72 h 4.72 (SE 0.15) P = 0.06). The respiratory exchange ratio fell progressively from 0.80 to 076 to 0.72 (P < 0.001). Blood glucose fell, whilst plasma glycerol and β-hydroxybutyrate rose and plasma lactate did not change. Plasma insulin and free triiodothyronine fell during starvation. Plasma adrenaline and noradrenaline were unchanged at 36 h, but were significantly increased after 72 h. Both sexes showed a similar pattern of response to starvation, although absolute values of blood pressure, forearm blood flow, metabolic rate and plasma catecholamines were higher in men than women. Acute starvation produces profound cardiovascular and metabolic changes which are not explained by the accompanying hormonal changes.

    • Send article to Kindle

      To send this article to your Kindle, first ensure no-reply@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about sending to your Kindle.

      Note you can select to send to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be sent to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

      Find out more about the Kindle Personal Document Service.

      The cardiovascular, metabolic and hormonal changes accompanying acute starvation in men and women
      Available formats
      ×
      Send article to Dropbox

      To send this article to your Dropbox account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your Dropbox account. Find out more about sending content to Dropbox.

      The cardiovascular, metabolic and hormonal changes accompanying acute starvation in men and women
      Available formats
      ×
      Send article to Google Drive

      To send this article to your Google Drive account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your Google Drive account. Find out more about sending content to Google Drive.

      The cardiovascular, metabolic and hormonal changes accompanying acute starvation in men and women
      Available formats
      ×
Copyright
Linked references
Hide All

This list contains references from the content that can be linked to their source. For a full set of references and notes please see the PDF or HTML where available.

S. A Amiel , A Maran , J. K. Powrie , A. M. Umpleby & I. A. Macdonald (1993). Gender differences in counterregulation to hypoglycaemia. Diabetologia 36, 460469.

B. Andersson , M. Elam , B. G. Wallin , P. Bjorntorp & O. K. Andersson (1991). Effect of energy-restricted diet on sympathetic muscle nerve activity in obese women. Hypertension 18, 783789.

B. Andersson , B. G. Wallin , T. Hedner , A. C. Ahlberg & O. K. Andersson (1988). Acute effects of short-term fasting on blood pressure, circulating noradrenaline and efferent sympathetic nerve activity. Acta Medica Scandinavica 223, 485490.

S. F. Beer , P. M. M. Bircham , S. R. Bloom , P. M. Clark , C. N. Hales , C. M. Hughes , C. T. Jones , D. R. Marsh , P. R. Raggatt & Findlay, A. L. R. (1989). The effect of a 72-h fast on plasma levels of pituitary, adrenal, thyroid, pancreatic and gastrointestinal hormones in healthy men and women.Journal of Endocrinology 120, 337350.

T. Bennett , I. A. Macdonald & R. Sainsbury (1984). The influence of acute starvation on the cardiovascular responses to lower body subatmospheric pressure or to standing in man. Clinical Science 66, 141146.

C. Berne , J. Fagius & F. Niklasson (1989). Sympathetic response to oral carbohydrate administration. Evidence from microelectrode nerve recordings.Journal of Clinical Investigation 84, 14031409.

P. R. Boulter , R. S. Hoffman & R. A. Arky (1973). Pattern of sodium excretion accompanying starvation. Metabolism 22, 675683.

J. N. Clore , P. S. Glickman , S. T. Helm , J. E. Nestler & W. G. Blackard (1989). Accelerated decline in hepatic glucose production during fasting in normal women compared with men. Metabolism 38, 11031107.

I. W. Fellows & I. A. Macdonald (1985). An automated method for the measurement of oxygen consumption and carbon dioxide excretion in man. Clinical Physics and Physiological Measurement 6, 349355.

R. T. Jung , P. S. Shetty , M. Barrand , B. A. Callingham & W. P. T. James (1979). Role of catecholamines in hypotensive response to dieting. British Medical Journal 1, 1213.

I. A. Macdonald & D. M. Lake (1985). An improved technique for extracting catecholamines from body fluids. Journal of Neuroscience Methods 13, 239248.

P. I. Mansell & I. A. Macdonald (1990). The effect of starvation on insulin-induced glucose disposal and thermogenesis in humans. Metabolism 39, 502510.

T. J. Merimee & S. E. Fineberg (1973). Homeostasis during fasting. 11. Hormone substrate differences between men and women. Journal of Clinical Endocrinology and Metabolism 37, 698702.

N. Moller , J. O.L Jorgensen J. F. Moller , J. F. Bak , N Porksen , K. G. M. M. Alberti & O. Schmitz (1990). Substrate metabolism during modest hyperinsulinaemia in response to isolated hyperketonaemia in insulin-dependent diabetic subjects. Metabolism 39, 13091313.

K. O'Dea , M. Esler , P. Leonard , J. R. Stockigt & P. Nestel (1982). Noradrenaline turnover during under- and over-eating in normal weight subjects.Metabolism 31, 896899.

J. Palmblad , L. Levi , A. Burger , A Melander , U. Westgren , H. von Schenck & G. Skude (1977). Effects of total energy withdrawal (fasting) on the levels of growth hormone, thyrotropin, cortisol, adrenaline, noradrenaline, T4, T3, and rT3 in healthy males. Acta Medica Scandinavica 201, 1522.

J. B de V Weir . (1949). New methods for calculating metabolic rate with specific reference to protein metabolism. Journal of Physiology 109, 19.

S. Welle , R. G. Schwartz & M. Statt (1991). Reduced metabolic rate during P-adrenergic blockade in humans.Metabolism 40, 619622.

R. J. Whitney (1953). The measurement of volume changes in human limbs. Journal of Physiology 121, 127.

Recommend this journal

Email your librarian or administrator to recommend adding this journal to your organisation's collection.

British Journal of Nutrition
  • ISSN: 0007-1145
  • EISSN: 1475-2662
  • URL: /core/journals/british-journal-of-nutrition
Please enter your name
Please enter a valid email address
Who would you like to send this to? *
×

Keywords:

Metrics

Altmetric attention score

Full text views

Total number of HTML views: 0
Total number of PDF views: 206 *
Loading metrics...

Abstract views

Total abstract views: 1110 *
Loading metrics...

* Views captured on Cambridge Core between September 2016 - 28th May 2017. This data will be updated every 24 hours.