Skip to main content Accessibility help
×
×
Home

The case for strategic international alliances to harness nutritional genomics for public and personal health

  • Jim Kaput (a1) (a2), Jose M. Ordovas (a3), Lynnette Ferguson (a4), Ben van Ommen (a5), Raymond L. Rodriguez (a1), Lindsay Allen (a6), Bruce N. Ames (a7), Kevin Dawson (a1), Bruce German (a8), Ronald Krauss (a7), Wasyl Malyj (a1), Michael C. Archer (a9), Stephen Barnes (a10), Amelia Bartholomew (a2), Ruth Birk (a11), Peter van Bladeren (a12), Kent J. Bradford (a13), Kenneth H. Brown (a14), Rosane Caetano (a15), David Castle (a16), Ruth Chadwick (a17), Stephen Clarke (a18), Karine Clément (a19), Craig A. Cooney (a20), Dolores Corella (a21), Ivana Beatrice Manica da Cruz (a22), Hannelore Daniel (a23), Troy Duster (a24), Sven O. E. Ebbesson (a25), Ruan Elliott (a26), Susan Fairweather-Tait (a26), Jim Felton (a27), Michael Fenech (a28), John W. Finley (a29), Nancy Fogg-Johnson (a30), Rosalynn Gill-Garrison (a31), Michael J. Gibney (a32), Peter J. Gillies (a33), Jan-Ake Gustafsson (a34), John L. Hartman (a35), Lin He (a36), Jae-Kwan Hwang (a37), Jean-Philippe Jais (a38), Yangsoo Jang (a39), Hans Joost (a40), Claudine Junien (a41), Mitchell Kanter (a42), Warren A. Kibbe (a43), Berthold Koletzko (a44), Bruce R. Korf (a35), Kenneth Kornman (a45), David W. Krempin (a46), Dominique Langin (a47), Denis R. Lauren (a4) (a48), Jong Ho Lee (a49), Gilbert A. Leveille (a50), Su-Ju Lin (a51), John Mathers (a52), Michael Mayne (a53), Warren McNabb (a4) (a54), John A. Milner (a55), Peter Morgan (a56), Michael Muller (a57), Yuri Nikolsky (a58), Frans van der Ouderaa (a59), Taesun Park (a60), Norma Pensel (a61), Francisco Perez-Jimenez (a62), Kaisa Poutanen (a63), Matthew Roberts (a64), Wim H.M. Saris (a65), Gertrud Schuster (a66), Andrew N. Shelling (a4) (a67), Artemis P. Simopoulos (a68), Sue Southon (a69), E. Shyong Tai (a70), Bradford Towne (a71), Paul Trayhurn (a72), Ricardo Uauy (a73), Willard J. Visek (a74), Craig Warden (a75), Rick Weiss (a76), John Wiencke (a77), Jack Winkler (a78), George L. Wolff (a79), Xi Zhao-Wilson (a80) and Jean-Daniel Zucker (a81)...
Abstract

Nutrigenomics is the study of how constituents of the diet interact with genes, and their products, to alter phenotype and, conversely, how genes and their products metabolise these constituents into nutrients, antinutrients, and bioactive compounds. Results from molecular and genetic epidemiological studies indicate that dietary unbalance can alter gene–nutrient interactions in ways that increase the risk of developing chronic disease. The interplay of human genetic variation and environmental factors will make identifying causative genes and nutrients a formidable, but not intractable, challenge. We provide specific recommendations for how to best meet this challenge and discuss the need for new methodologies and the use of comprehensive analyses of nutrient–genotype interactions involving large and diverse populations. The objective of the present paper is to stimulate discourse and collaboration among nutrigenomic researchers and stakeholders, a process that will lead to an increase in global health and wellness by reducing health disparities in developed and developing countries.

Copyright
Corresponding author
Corresponding author: Dr Jim Kaput, fax +1 312 829 3357 email jkaput@uic.edu
Footnotes
Hide All

This document is an outgrowth of the Bruce Ames International Symposium on Nutritional Genomics held at the University of California, Davis, CA on 22–24 October 2004. The statements and opinions expressed are those of symposium participants and others who are contributing to nutrigenomics or related research fields. The present paper is intended to stimulate discussion about the interplay of nutrition and genetics and the potential of nutrigenomics to improve global health.

Footnotes
References
Hide All
Albrecht, U & Eichele, G (2003) The mammalian circadian clock. Curr Opin Genet Dev 13, 271277.
American Diabetes Association (2005). Other medications for type 2 diabetes. http://www.diabetes.org/type-2-diabetes/oral-medications.jsp
Austin, MA, Harding, SE & McElroy, CE (2003) Monitoring ethical, legal, and social issues in developing population genetic databases. Genet Med 5, 451457.
Cardon, LR & Bell, JI (2001) Association study designs for complex diseases. Nat Rev Genet 2, 9199.
Carlborg, O & Haley, CS (2004) Epistasis: too often neglected in complex trait studies?. Nat Rev Genet 5, 618625.
Cech, TR & Rubin, GM (2004) Nurturing interdisciplinary research. Nat Struct Mol Biol 11, 11661169.
Cheverud, JM, Ehrich, TH, Hrbek, T, Kenney, JP, Pletscher, LS & Semenkovich, CF (2004) Quantitative trait loci for obesity- and diabetes-related traits and their dietary responses to high-fat feeding in LGXSM recombinant inbred mouse strains. Diabetes 53, 33283336.
Cooney, CA, Dave, AA & Wolff, GL (2002) Maternal methyl supplements in mice affect epigenetic variation and DNA methylation of offspring. J Nutr 132, 2393S2400S.
Corella, D & Ordovas, JM (2004) The metabolic syndrome: a crossroad for genotype-phenotype associations in atherosclerosis. Curr Atheroscler Rep 6, 186196.
Davis, CD & Milner, J (2004) Frontiers in nutrigenomics, proteomics, metabolomics and cancer prevention. Mutat Res 551, 5164.
Devries, JW (2004) Dietary fiber: the influence of definition on analysis and regulation. J AOAC Int 87, 682706.
Dreon, DM, Fernstrom, HA, Williams, PT & Krauss, RM (1999) A very-low-fat diet is not associated with improved lipoprotein profiles in men with a predominance of large, low-density lipoproteins. Am J Clin Nutr 69, 411418.
Ferguson, LR & Harris, PJ (2003) The dietary fibre debate: more food for thought. Lancet 361, 14871488.
Fleeman, LM & Rand, JS (2001) Management of canine diabetes. Vet Clin North Am Small Anim Pract 31, 855880.
Food and Agriculture Organization (2005). Food Composition: Publications. http://www.fao.org/infoods/publications_en.stm
Francis, GA, Fayard, E, Picard, F & Auwerx, J (2003) Nuclear receptors and the control of metabolism. Annu Rev Physiol 65, 261311.
Freedman, ML, Reich, D & Penney, KL (2004) Assessing the impact of population stratification on genetic association studies. Nat Genet 36, 388393.
Gillies, PJ (2003) Nutrigenomics: the Rubicon of molecular nutrition. J Am Diet Assoc 103, S50S55.
Gleeson, M, Nieman, DC & Pedersen, BK (2004) Exercise, nutrition and immune function. J Sports Sci 22, 115125.
Haga, SB, Khoury, MJ & Burke, W (2003) Genomic profiling to promote a healthy lifestyle: not ready for prime time. Nat Genet 34, 347350.
Hartman, JL, Garvik, B & Hartwell, L (2001) Principles for the buffering of genetic variation. Science 291, 10011004.
Hirschhorn, JN, Lohmueller, K, Byrne, E & Hirschhorn, K (2002) A comprehensive review of genetic association studies. Genet Med 4, 4561.
Hribal, ML, Oriente, F & Accili, D (2002) Mouse models of insulin resistance. Am J Physiol 282, E977E981.
International Hapmap Consortium (2003) The International HapMap Project. Nature 426, 789796.
International HapMap Consortium (2004) Integrating ethics and science in the International HapMap Project. Nat Rev Genet 5, 467475.
Irwin, M (2002) Effects of sleep and sleep loss on immunity and cytokines. Brain Behav Immun 16, 503512.
Irwin, M, Clark, C, Kennedy, B, Christian, Gillin J & Ziegler, M (2003) Nocturnal catecholamines and immune function in insomniacs, depressed patients, and control subjects. Brain Behav Immun 17, 365372.
Jackson Laboratory (2005). The Jackson Laboratory – Advancing Research in Human Health. http://www.jax.org
Jacobs, MN & Lewis, DF (2002) Steroid hormone receptors and dietary ligands: a selected review. Proc Nutr Soc 61, 105122.
Jimenez-Sanchez, G, Childs, B & Valle, D (2001) Human disease genes. Nature 409, 853855.
Jorgenson, E, Tang, H & Gadde, M (2005) Ethnicity and human genetic linkage maps. Am J Hum Genet 76, 276290.
Kaput, J (2004) Diet-disease gene interactions. Nutrition 20, 2631.
Kaput, J, Klein, KG, Reyes, EJ, Kibbe, WA, Cooney, CA, Jovanovic, B, Visek, WJ & Wolff, GL (2004) Identification of genes contributing to the obese yellow Avy phenotype: caloric restriction, genotype, diet x genotype interactions. Physiol Genomics 18, 316324.
Kaput, J & Rodriguez, RL (2004) Nutritional genomics: the next frontier in the postgenomic era. Physiol Genomics 16, 166177.
Keita, SO, Kittles, RA, Royal, CD, Bonney, GE, Furbert-Harris, P, Dunston, GM & Rotimi, CN (2004) Conceptualizing human variation. Nat Genet 36, Suppl. 1, S17S20.
Kimura, M, Umegaki, K, Higuchi, M, Thomas, P & Fenech, M (2004) Methylenetetrahydrofolate reductase C677T polymorphism, folic acid and riboflavin are important determinants of genome stability in cultured human lymphocytes. J Nutr 134, 4856.
Lan, H, Rabaglia, ME, Stoehr, JP, Nadler, ST, Schueler, KL, Zou, F, Yandell, BS & Attie, AD (2003) Gene expression profiles of nondiabetic and diabetic obese mice suggest a role of hepatic lipogenic capacity in diabetes susceptibility. Diabetes 52, 688700.
Lander, E & Kruglyak, L (1995) Genetic dissection of complex traits: guidelines for interpreting and reporting linkage results. Nat Genet 11, 241247.
Lin, SJ & Guarente, L (2003) Nicotinamide adenine dinucleotide, a metabolic regulator of transcription, longevity and disease. Curr Opin Cell Biol 15, 241246.
Lin, SJ, Kaeberlein, M, Andalis, AA, Sturtz, LA, Defossez, PA, Culotta, VC, Fink, GR & Guarente, L (2002) Calorie restriction extends Saccharomyces cerevisiae lifespan by increasing respiration. Nature 418, 344348.
Linder, CC (2001) The influence of genetic background on spontaneous and genetically engineered mouse models of complex diseases. Lab Anim (NY) 30, 3439.
Lohmueller, KE, Pearce, CL, Pike, M, Lander, ES & Hirschhorn, JN (2003) Meta-analysis of genetic association studies supports a contribution of common variants to susceptibility to common disease. Nat Genet 33, 177182.
Loktionov, A (2003) Common gene polymorphisms and nutrition: emerging links with pathogenesis of multifactorial chronic diseases (review). J Nutr Biochem 14, 426451.
Loktionov, A, Scollen, S, McKeown, N & Bingham, SA (2000) Gene-nutrient interactions: dietary behaviour associated with high coronary heart disease risk particularly affects serum LDL-cholesterol in apolipoprotein E epsilon4-carrying free-living individuals. Br J Nutr 84, 885890.
Maschke, KJ & Murray, TH (2004) Ethical issues in tissue banking for research: the prospects and pitfalls of setting international standards. Theor Med Bioeth 25, 143155.
Moore, JH (2003) The ubiquitous nature of epistasis in determining susceptibility to common human diseases. Hum Hered 56, 7382.
Muller, M & Kersten, S (2003) Opinion: Nutrigenomics: goals and strategies. Nat Rev Genet 4, 315322.
Naciff, JM, Jump, ML, Torontali, SM, Carr, GJ, Tiesman, JP, Overmann, GJ & Daston, GP (2002) Gene expression profile induced by 17alpha-ethynyl estradiol, bisphenol A, and genistein in the developing female reproductive system of the rat. Toxicol Sci 68, 184199.
National Institute of General Medical Services, (2005) NIGMS – Research Funding: Goals for the Pharmacogenetics Research Network and PharmGKB. http://www.nigms.nih.gov/pharmacogenetics/goals.html
Nieman, DC, Davis, JM & Brown, VA (2004) Influence of carbohydrate ingestion on immune changes after 2 h of intensive resistance training. J Appl Physiol 96, 12921298.
Nieman, DC, Davis, JM, Henson, DA (2003 a) Carbohydrate ingestion influences skeletal muscle cytokine mRNA and plasma cytokine levels after a 3-h run. J Appl Physiol 94, 19171925.
Nieman, DC, Dumke, CI, Henson, DA, McAnulty, SR, McAnulty, LS, Lind, RH & Morrow, JD (2003 b) Immune and oxidative changes during and following the Western States Endurance Run. Int J Sports Med 24, 541547.
Ordovas, JM (2004) The quest for cardiovascular health in the genomic era: nutrigenetics and plasma lipoproteins. Proc Nutr Soc 63, 145152.
Ordovas, JM & Corella, D (2004) Nutritional genomics. Annu Rev Genomics Hum Genet 5, 71118.
Pandya, RJ, Solomon, G, Kinner, A & Balmes, JR (2002) Diesel exhaust and asthma: hypotheses and molecular mechanisms of action. Environ Health Perspect 110, Suppl. 1, 103112.
Park, EI, Paisley, EA, Mangian, HJ, Swartz, DA, Wu, MX, O'Morchoe, PJ, Behr, SR, Visek, WJ & Kaput, J (1997) Lipid level and type alter stearoyl CoA desaturase mRNA abundance differently in mice with distinct susceptibilities to diet-influenced diseases. J Nutr 127, 566573.
Parra, EJ, Kittles, RA & Shriver, MD (2004) Implications of correlations between skin color and genetic ancestry for biomedical research. Nat Genet 36, Suppl. 1, S54S60.
Pereira, MA, Weggemans, RM, Jacobs, DR Jr, Hannan, PJ, Zock, PL, Ordovas, JM & Katan, MB (2004) Within-person variation in serum lipids: implications for clinical trials. Int J Epidemiol 33, 534541.
Pharmacogenetics and Pharmacogenomics Knowledge Base (2005) PharmGKB. http://www.pharmgkb.org/
Pianetti, S, Guo, S, Kavanagh, KT & Sonenshein, GE (2002) Green tea polyphenol epigallocatechin-3 gallate inhibits Her-2/neu signaling, proliferation, and transformed phenotype of breast cancer cells. Cancer Res 62, 652655.
Pike, AC, Brzozowski, AM, Hubbard, RE, Bonn, T, Thorsell, AG, Engstrom, O, Ljunggren, J, Gustafsson, JA & Carlquist, M (1999) Structure of the ligand-binding domain of oestrogen receptor beta in the presence of a partial agonist and a full antagonist. EMBO J 18, 46084618.
Prabhakar, NR & Peng, YJ (2004) Peripheral chemoreceptors in health and disease. J Appl Physiol 96, 359366.
Program for Genetic Interaction (2005) PROGENI Network – NHLBI Gene by Environment Interaction Studies. http://www.biostat.wustl.edu/progeni/
Rebbeck, TR, Spitz, M & Wu, X (2004) Assessing the function of genetic variants in candidate gene association studies. Nat Rev Genet 5, 589597.
Redwine, L, Hauger, RL, Gillin, JC & Irwin, M (2000) Effects of sleep and sleep deprivation on interleukin-6, growth hormone, cortisol, and melatonin levels in humans. J Clin Endocrinol Metab 85, 35973603.
Reich, DE & Goldstein, DB (2001) Detecting association in a case-control study while correcting for population stratification. Genet Epidemiol 20, 416.
Reifsnyder, PC, Churchill, G & Leiter, EH (2000) Maternal environment and genotype interact to establish diabesity in mice. Genome Res 10, 15681578.
Risch, N (1997) Evolving methods in genetic epidemiology II. Genetic linkage from an epidemiologic perspective. Epidemiol Rev 19, 2432.
Rossmeisl, M, Rim, JS, Koza, RA & Kozak, LP (2003) Variation in type 2 diabetes – related traits in mouse strains susceptible to diet-induced obesity. Diabetes 52, 19581966.
Sachs, JD (2005) The End of Poverty. Economic Possibilities for Our Time. New York: The Penguin Press.
Seeley, RJ, Drazen, DL & Clegg, DJ (2004) The critical role of the melanocortin system in the control of energy balance. Annu Rev Nutr 24, 133149.
Serhan, CN, Clish, CB, Brannon, J, Colgan, SP, Chiang, N & Gronert, K (2000) Novel functional sets of lipid-derived mediators with antiinflammatory actions generated from omega-3 fatty acids via cyclooxygenase 2-nonsteroidal antiinflammatory drugs and transcellular processing. J Exp Med 192, 11971204.
Simopoulos, AP & Ordovas, JM (2004) Nutrigenetics and Nutrigenomics. Basel: Karger.
Stoehr, JP, Nadler, ST, Schueler, KL, Rabaglia, ME, Yandell, BS, Metz, SA & Attie, AD (2000) Genetic obesity unmasks nonlinear interactions between murine type 2 diabetes susceptibility loci. Diabetes 49, 19461954.
Tai, ES & Tan, CE (2004) Genes, diet and serum lipid concentrations: lessons from ethnically diverse populations and their relevance to coronary heart disease in Asia. Curr Opin Lipidol 15, 512.
Tang, H, Quertermous, T & Rodriguez, B (2005) Genetic structure, self-identified race/ethnicity, and confounding in case-control association studies. Am J Hum Genet 76, 268275.
Tirona, RG, Leake, BF, Podust, LM & Kim, RB (2004) Identification of amino acids in rat pregnane X receptor that determine species-specific activation. Mol Pharmacol 65, 3644.
Tomita, M, Irwin, KI, Xie, ZJ & Santoro, TJ (2002) Tea pigments inhibit the production of type 1 (T(H1)) and type 2 (T(H2)) helper T cell cytokines in CD4(+) T cells. Phytother Res 16, 3642.
University of California, Davis, (2005) Program in International Nutrition. http://nutrition.ucdavis.edu/pin/
Van Ommen, B & Stierum, R (2002) Nutrigenomics: exploiting systems biology in the nutrition and health arena. Curr Opin Biotechnol 13, 517521.
Waterston, RH, Lindblad-Toh, K & Birney, E (2002) Initial sequencing and comparative analysis of the mouse genome. Nature 420, 520562.
Watkins, RE, Maglich, JM, Moore, LB, Wisely, GB, Noble, SM, Davis-Searles, PR, Lambert, MH, Kliewer, SA & Redinbo, MR (2003) 2·1 A crystal structure of human PXR in complex with the St. John's wort compound hyperforin. Biochemistry 42, 14301438.
Recommend this journal

Email your librarian or administrator to recommend adding this journal to your organisation's collection.

British Journal of Nutrition
  • ISSN: 0007-1145
  • EISSN: 1475-2662
  • URL: /core/journals/british-journal-of-nutrition
Please enter your name
Please enter a valid email address
Who would you like to send this to? *
×

Keywords

Metrics

Altmetric attention score

Full text views

Total number of HTML views: 0
Total number of PDF views: 0 *
Loading metrics...

Abstract views

Total abstract views: 0 *
Loading metrics...

* Views captured on Cambridge Core between <date>. This data will be updated every 24 hours.

Usage data cannot currently be displayed