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The case for strategic international alliances to harness nutritional genomics for public and personal health

  • Jim Kaput (a1) (a2), Jose M. Ordovas (a3), Lynnette Ferguson (a4), Ben van Ommen (a5), Raymond L. Rodriguez (a1), Lindsay Allen (a6), Bruce N. Ames (a7), Kevin Dawson (a1), Bruce German (a8), Ronald Krauss (a7), Wasyl Malyj (a1), Michael C. Archer (a9), Stephen Barnes (a10), Amelia Bartholomew (a2), Ruth Birk (a11), Peter van Bladeren (a12), Kent J. Bradford (a13), Kenneth H. Brown (a14), Rosane Caetano (a15), David Castle (a16), Ruth Chadwick (a17), Stephen Clarke (a18), Karine Clément (a19), Craig A. Cooney (a20), Dolores Corella (a21), Ivana Beatrice Manica da Cruz (a22), Hannelore Daniel (a23), Troy Duster (a24), Sven O. E. Ebbesson (a25), Ruan Elliott (a26), Susan Fairweather-Tait (a26), Jim Felton (a27), Michael Fenech (a28), John W. Finley (a29), Nancy Fogg-Johnson (a30), Rosalynn Gill-Garrison (a31), Michael J. Gibney (a32), Peter J. Gillies (a33), Jan-Ake Gustafsson (a34), John L. Hartman (a35), Lin He (a36), Jae-Kwan Hwang (a37), Jean-Philippe Jais (a38), Yangsoo Jang (a39), Hans Joost (a40), Claudine Junien (a41), Mitchell Kanter (a42), Warren A. Kibbe (a43), Berthold Koletzko (a44), Bruce R. Korf (a35), Kenneth Kornman (a45), David W. Krempin (a46), Dominique Langin (a47), Denis R. Lauren (a4) (a48), Jong Ho Lee (a49), Gilbert A. Leveille (a50), Su-Ju Lin (a51), John Mathers (a52), Michael Mayne (a53), Warren McNabb (a4) (a54), John A. Milner (a55), Peter Morgan (a56), Michael Muller (a57), Yuri Nikolsky (a58), Frans van der Ouderaa (a59), Taesun Park (a60), Norma Pensel (a61), Francisco Perez-Jimenez (a62), Kaisa Poutanen (a63), Matthew Roberts (a64), Wim H.M. Saris (a65), Gertrud Schuster (a66), Andrew N. Shelling (a4) (a67), Artemis P. Simopoulos (a68), Sue Southon (a69), E. Shyong Tai (a70), Bradford Towne (a71), Paul Trayhurn (a72), Ricardo Uauy (a73), Willard J. Visek (a74), Craig Warden (a75), Rick Weiss (a76), John Wiencke (a77), Jack Winkler (a78), George L. Wolff (a79), Xi Zhao-Wilson (a80) and Jean-Daniel Zucker (a81)...

Nutrigenomics is the study of how constituents of the diet interact with genes, and their products, to alter phenotype and, conversely, how genes and their products metabolise these constituents into nutrients, antinutrients, and bioactive compounds. Results from molecular and genetic epidemiological studies indicate that dietary unbalance can alter gene–nutrient interactions in ways that increase the risk of developing chronic disease. The interplay of human genetic variation and environmental factors will make identifying causative genes and nutrients a formidable, but not intractable, challenge. We provide specific recommendations for how to best meet this challenge and discuss the need for new methodologies and the use of comprehensive analyses of nutrient–genotype interactions involving large and diverse populations. The objective of the present paper is to stimulate discourse and collaboration among nutrigenomic researchers and stakeholders, a process that will lead to an increase in global health and wellness by reducing health disparities in developed and developing countries.

Corresponding author
Corresponding author: Dr Jim Kaput, fax +1 312 829 3357 email
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This document is an outgrowth of the Bruce Ames International Symposium on Nutritional Genomics held at the University of California, Davis, CA on 22–24 October 2004. The statements and opinions expressed are those of symposium participants and others who are contributing to nutrigenomics or related research fields. The present paper is intended to stimulate discussion about the interplay of nutrition and genetics and the potential of nutrigenomics to improve global health.

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