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Dietary oxidized oil influences the levels of type 2 T-helper cell-related antibody and inflammatory mediators in mice

Published online by Cambridge University Press:  09 March 2007

Bi-Fong Lin ,
Chia-Chun Lai ,
Kai-Wei Lin  and
Bor-Luen Chiang
Bi-Fong Lin
Affiliation:
Laboratory of Nutritional Chemistry, Department of Agricultural Chemistry, College of Agriculture, National Taiwan University, Taipei, Taiwan 10764, Republic of China
Chia-Chun Lai
Affiliation:
Laboratory of Nutritional Chemistry, Department of Agricultural Chemistry, College of Agriculture, National Taiwan University, Taipei, Taiwan 10764, Republic of China
Kai-Wei Lin
Affiliation:
Laboratory of Nutritional Chemistry, Department of Agricultural Chemistry, College of Agriculture, National Taiwan University, Taipei, Taiwan 10764, Republic of China
Bor-Luen Chiang*
Affiliation:
Graduate Institute of Clinical Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan 100, Republic of China
*
*Corresponding author: Dr Bor-Luen Chiang, fax +2 2397 2031 email gicmbor@ha.mc.ntu.edu.tw
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Abstract

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The aim of this present study was to investigate the effect of amount and degree of oxidation of dietary oil on type 2 T-helper cell (TH)-related immune responses. Four groups of BALB/c mice were fed either 50 g soyabean oil/kg (50-S), 50 g oxidized oil/kg (50-O), 150 g soyabean oil/kg (150-S) or 150 g oxidized oil/kg (150-O). After 14 weeks consuming the experimental diets, the mice were immunized with ovalbumin (OVA) plus Al and antigen-specific immunoglobulin (Ig)E, IgG1 and IgG2a, inflammatory mediators such as prostaglandin (PG) E2 and leukotriene (LT)B4 were determined. Higher hepatic microsomal cytochrome P450 was noted in mice fed 150 g oxidized oil/kg compared with those of other groups. OVA-specific IgG1 and IgE were higher in mice fed 150 g oxidized oil/kg compared with those of the other groups. The data suggested the interleukin (IL)-4: interferon (IFN)-γ ratio was higher in mice fed 50 g dietary oxidized oil/kg compared with that of the 50-S group. The IL-5:IFN-γ ratios were higher in the 150-S and 150-O groups than in the 50-S and 50-O groups. PGE2 and LTB4 produced by macrophages stimulated by lipopolysaccharide were highest in mice in the 150 g oxidized oil/kg group. The data suggested that an increased intake of oxidized oil might exert an unfavourable effect on the TH2 response involved in allergic disease.

Keywords

Oxidized oilImmunoglobulin EAsthmaProstaglandin E2Leukotrienes
Type
Research Article
Information
British Journal of Nutrition , Volume 84 , Issue 6 , December 2000 , pp. 911 - 917
Copyright
Copyright © The Nutrition Society 2000

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